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Prenatal maternal depression and child serotonin transporter linked polymorphic region (5-HTTLPR) and dopamine receptor D4 (DRD4) genotype predict negative emotionality from 3 to 36 months

Published online by Cambridge University Press:  18 July 2016

Cathryn Gordon Green
Affiliation:
McGill University Jewish General Hospital
Vanessa Babineau
Affiliation:
McGill University Jewish General Hospital
Alexia Jolicoeur-Martineau
Affiliation:
Jewish General Hospital
Andrée-Anne Bouvette-Turcot
Affiliation:
McGill University University of Montreal
Klaus Minde
Affiliation:
McGill University
Roberto Sassi
Affiliation:
St.-Joseph's Healthcare Hamilton and McMaster University
Martin St-André
Affiliation:
CHU Sainte-Justine
Normand Carrey
Affiliation:
Dalhousie University
Leslie Atkinson
Affiliation:
Ryerson University
James L. Kennedy
Affiliation:
Center for Addiction and Mental Health
Meir Steiner
Affiliation:
St.-Joseph's Healthcare Hamilton and McMaster University
John Lydon
Affiliation:
McGill University Ludmer Centre for Neuroinformatics and Mental Health Douglas Mental Health University Institute
Helene Gaudreau
Affiliation:
Ludmer Centre for Neuroinformatics and Mental Health Douglas Mental Health University Institute
Jacob A. Burack
Affiliation:
McGill University
Robert Levitan
Affiliation:
Center for Addiction and Mental Health
Michael J. Meaney
Affiliation:
McGill University Ludmer Centre for Neuroinformatics and Mental Health Douglas Mental Health University Institute
Ashley Wazana*
Affiliation:
McGill University Jewish General Hospital Ludmer Centre for Neuroinformatics and Mental Health Douglas Mental Health University Institute
*
Address correspondence and reprint requests to: Ashley Wazana, Centre for Child Development and Mental Health, Jewish General Hospital, 4335 Cote Sainte Catherine Road, Montreal, QC H3T 1E4, Canada; E-mail: ashley.wazana@mcgill.ca.

Abstract

Prenatal maternal depression and a multilocus genetic profile of two susceptibility genes implicated in the stress response were examined in an interaction model predicting negative emotionality in the first 3 years. In 179 mother–infant dyads from the Maternal Adversity, Vulnerability, and Neurodevelopment cohort, prenatal depression (Center for Epidemiologic Studies Depressions Scale) was assessed at 24 to 36 weeks. The multilocus genetic profile score consisted of the number of susceptibility alleles from the serotonin transporter linked polymorphic region gene (5-HTTLPR): no long-rs25531(A) (LA: short/short, short/long-rs25531(G) [LG], or LG/LG] vs. any LA) and the dopamine receptor D4 gene (six to eight repeats vs. two to five repeats). Negative emotionality was extracted from the Infant Behaviour Questionnaire—Revised at 3 and 6 months and the Early Child Behavior Questionnaire at 18 and 36 months. Mixed and confirmatory regression analyses indicated that prenatal depression and the multilocus genetic profile interacted to predict negative emotionality from 3 to 36 months. The results were characterized by a differential susceptibility model at 3 and 6 months and by a diathesis–stress model at 36 months.

Type
Regular Articles
Copyright
Copyright © Cambridge University Press 2016 

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Footnotes

This research was made possible by grants from the Canadian Institutes of Health Research, the March of Dimes Foundation, and the Fonds de Research du Quebec. The Maternal Adversity, Vulnerability, and Neurodevelopment (MAVAN) project has been supported by funding from the McGill Faculty of Medicine, the Blema & Arnold Steinberg Family Foundation, and the Canadian Institutes for Health Research. We thank all members and participants of the MAVAN project for their time and commitment to this research. We also thank David Brownlee, Vincent Jolivet, Amber Rider, Patricia Szymkow, and Michael Pluess for their contributions.

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