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Developmental precipitants of borderline personality disorder

Published online by Cambridge University Press:  12 December 2005

ABIGAIL A. BAIRD ,
HEATHER B. VEAGUE  and
C. ELIZABETH RABBITT
ABIGAIL A. BAIRD
Affiliation:
Dartmouth College
HEATHER B. VEAGUE
Affiliation:
Dartmouth College
C. ELIZABETH RABBITT
Affiliation:
Dartmouth College
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Abstract

Traditional theories regarding the etiology of borderline personality disorder have focused on poor attachment figures and/or traumatic experience. The present review posits an additional pathogenic course for this disorder. Specifically, the proposed mechanism involves a basic disruption of the neural hardware that supports the formation and maintenance of unconscious emotional memory, hardware essential for the formation of early attachments. It is further theorized that this early disruption has ongoing effects on both behavioral and concomitant neural development. Within this model, adolescence is described as a period of intense change that serves as the tipping point for the onset of borderline personality disorder.

Type
Research Article
Information
Development and Psychopathology , Volume 17 , Issue 4 , December 2005 , pp. 1031 - 1049
Copyright
© 2005 Cambridge University Press

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References

REFERENCES

Agrawal, H. R., Gunderson, J., Holmes, B. M., & Lyons–Ruth, K. (2004). Attachment studies with borderline patients: A review. Harvard Review of Psychiatry 12, 94–104.Google Scholar
Amini, F., Lewis, T., Lannon, R., Louie, A., Baumbacher, G., McGuiness, T., et al. (1996). Affect, attachment, memory: Contributions toward psychological integration. Psychiatry 59, 213–239.Google Scholar
Bachevalier, J. (1990). Ontogenetic development of habit memory and function in primates. In A. Diamond (Ed.), The developmental and neural bases of higher cognitive functions. New York: New York Academy of Sciences.
Bachevalier, J. (1991). Memory loss and socioemotional disturbances following neonatal damage to the limbic system in monkeys. Advances in Neuropsychology and Psychopharmacology 1, 129–140.Google Scholar
Bachevalier, J., & Mishkin, M. (1984). An early and a late developing system for learning and retention in infant monkeys. Behavioral Neuroscience 98, 770–778.Google Scholar
Barker, R. G., & Wright, H. F. (1951). One boy's day: A specimen record of behavior. New York: Harper & Brothers.
Baron, M., Gruen, R., Asnis, L., & Lord, S. (1985). Familial transmission of schizotypal and borderline personality disorders. American Journal of Psychiatry 142, 927–934.Google Scholar
Benes, F. M., Vincent, S. L., Molloy, R., & Khan, Y. (1996). Increased interaction of dopamine-immunoreactive varicosities with GABA neurons of rat medial prefrontal cortex occurs during the postweanling period. Synapse 23, 237–245.Google Scholar
Benjamin, L. S. (1992). Interpersonal diagnosis and treatment of personality disorders (2nd ed.). New York: Guilford Press.
Benjamin, L. S. (1996). An interpersonal theory of personality disorders. In J. F. Clarkin & M. Lenzenweger (Eds.), Major theories of personality disorders. New York: Guilford Press.
Bertolino, A., Saunders, R. C., Mattay, V. S., Bachevalier, J., Frank, J. A., & Weinberger, D. R. (1997). Altered development of prefrontal neurons in rhesus monkeys with neonatal mesial temporo-limbic lesions: A proton magnetic resonance spectroscopic imaging study. Cerebral Cortex 7, 740–748.Google Scholar
Bielsky, I. F., & Young, L. J. (2004). Oxytocin, vasopressin, and social recognition in mammals. Peptides 25, 1565–1574.Google Scholar
Bowlby, J. (1969). Attachment and loss: Vol. 1. Attachment (2nd ed.). New York: Basic Books.
Brambilla, P., Soloff, P. H., Sala, M., Nicoletti, M. A., Keshavan, M. S., & Soares, J. C. (2004). Anatomical MRI study of borderline personality disorder patients. Psychiatry Research 131, 125–133.Google Scholar
Brown, B. B., Mounts, N., Lamborn, S. D., & Steinberg, L. (1993). Parenting practices and peer group affiliation in adolescence. Child Development 64, 467–482.Google Scholar
Bruner, J. S., & Postman, L. (1947). Emotional selectivity in perception and reaction. Journal of Personality 16, 69–67.Google Scholar
Casey, B. J., Giedd, J. N., & Thomas, K. M. (2000). Structural and functional brain development and its relation to cognitive development. Biological Psychology 54, 241–257.Google Scholar
Casey, B. J., Trainor, R., Giedd, J. N., Vauss, Y., Vaituzis, C. K., Hamburger, S. D., et al. (1997). The role of the anterior cingulate in automatic and controlled processes: A developmental neuroanatomical study. Developmental Psychobiology 30, 61–69.Google Scholar
Cicchetti, D., & Tucker, D. (1994). Development and self-regulatory structures of the mind. Development and Psychopathology 6, 533–549.Google Scholar
Critchley, H. D., Mathias, C. J., & Dolan, R. J. (2001). Neuroanatomical basis for first- and second-order representations of bodily states. Nature Neuroscience 4, 207–212.Google Scholar
Cummings, J. L. (1995). Anatomic and behavioral aspects of frontal-subcortical circuits. Annuals of the New York Academy of Science 769, 1–13.Google Scholar
Damasio, A. R. (1994). Descartes' error: Emotion, reason, and the human brain. New York: Grosset/Putnam.
Darwin, C. (1872). The expression of the emotions in man and animals. Westport, CT: Greenwood Press.
Depue, R. A., & Lenzenweger, M. F. (2005). A neurobehavioral dimensional model of personality disturbance. In M. F. Lenzenweger & R. A. Depue (Eds.), Major theories of personality disorder (2nd ed., pp. 391–453). New York: Guilford Press.
Donald, M. (1991). Origins of the modern mind. Cambridge, MA: Harvard University Press.
Driessen, M., Hermann, J., Stahl, K., Zwaan, M., Meier, S., Hill, A., et al. (2000). Magnetic resonance imaging of volume of hippocampus and amygdala in women with borderline personality disorder and early traumatization. Archives of General Psychiatry 57, 1115–1122.Google Scholar
Eslinger, P. J., & Damasio, A. R. (1985). Severe disturbance of higher cognitive function after bilateral frontal lobe ablation: Patient EVR. Neurology 35, 1731–1741.Google Scholar
Foa, E. B., Feske, U., Murdock, T. B., Kozak, M. J., & McCarthy, P. R. (1991). Processing of threat-related material in rape victims. Journal of Abnormal Psychology 100, 156–162.Google Scholar
Fraley, R. C., & Spieker, S. J. (2003). Are infant attachment patterns continuously or categorically distributed? A taxometric analysis of Strange Situation behavior. Developmental Psychology 39, 387–404.Google Scholar
Giedd, J. N., Castellanos, F. X., Rajapakse, J. C., Vaituzis, A. C., & Rapoport, J. L. (1997). Sexual dimorphism of the developing human brain. Progress in Neuro-psychopharmacology and Biological Psychiatry 21, 1185–1201.Google Scholar
Greene, A. L., & Larson, R. W. (1991). Variation in stress reactivity during adolescence. In E. M. Cummings & A. L. Greene (Eds.), Life-span developmental psychology: Perspectives on stress and coping (pp. 195–209). Hillsdale, NJ: Erlbaum.
Greenspan, S., & Lourie, R. S. (1981). Developmental structuralist approach to the classification of adaptive and pathologic personality organizations: Infancy and early childhood. American Journal of Psychiatry 138, 725–735.Google Scholar
Gunderson, J. G., & Phillips, K. A. (1991). A current view of the interface between borderline personality disorder and depression. American Journal of Psychiatry 132, 1–10.Google Scholar
Hartman, C. R., & Burgess, A. W. (1993). Information processing of trauma. Child Abuse and Neglect 17, 47–58.Google Scholar
Herpertz, S. C., Dietrich, T. M., Wenning, B., Krings, T., Erberich, S. G., Willmes, K., et al. (2001). Evidence of abnormal amygdala functioning in borderline personality disorder: A functional MRI study. Biological Psychiatry 50, 292–298.Google Scholar
Hilliard, S., Domjan, M., Nguyen, M., & Cusato, B. (1998). Dissociation of conditioned appetitive and consummatory sexual behavior: Satiation and extinction tests. Animal Learning and Behavior 26, 20–33.Google Scholar
Hill, T., Lewicki, P., Czyzewska, M., & Schuller, G. (1990). The role of learned inferential encoding rules in the perception of faces: Effects of nonconscious self-perpetuation of bias. Journal of Experimental Social Psychology 26, 350–371.Google Scholar
Horesh, N., Sever, J., & Apter, A. (2003). A comparison of life events between suicidal adolescents with major depression and borderline personality disorder. Comprehensive Psychiatry 44, 277–283.Google Scholar
Hull, A. M. (2002). Neuroimaging findings in post-traumatic stress disorder systematic review. British Journal of Psychiatry 181, 102–110.Google Scholar
Insel, T. R. (1997). A neurobiological basis of social attachment. American Journal of Psychiatry 154, 726–735.Google Scholar
Insel, T. R. (2003). Is social attachment an addictive disorder? Physiology and Behavior 79, 351–357.Google Scholar
Jacobs, J. E., Vernon, M. K., & Eccles, J. S. (2004). Relations between social self-perceptions, time use, and prosocial or problem behaviors during adolescence. Journal of Adolescent Research 19, 45–62.Google Scholar
Kagan, J. (1996). On attachment. Harvard Review of Psychiatry 3, 104–106.Google Scholar
Kagan, J., & Zentner, M. (1996). Early childhood predictors of adult psychopathology. Harvard Review of Psychiatry 3, 341–350.Google Scholar
Kendrick, K. M. (2004). The neurobiology of social bonds. Journal of Neuroendocrinology 16, 1007–1008.Google Scholar
Kernberg, O. F. (1976). Technical considerations in the treatment of borderline personality organization. Journal of the American Psychoanalytic Association 24, 795–829.Google Scholar
Kernberg, O. F. (1996). A psychoanalytic theory of personality disorders. In J. F. Clarkin & M. F. Lenzenweger (Eds.), Major theories of personality disorders. New York: Guilford Press.
Kirsh, S. J., & Cassidy, J. (1997). Preschoolers' attention to and memory for attachment-relevant information. Child Development 68, 1143–1153.Google Scholar
Kohut, H. (1971). The analysis of the self. New York: International Universities Press.
Korfine, L. (1998). Memory functioning in borderline personality disorder. Unpublished doctoral dissertation, Harvard University.
Korfine, L., & Hooley, J. M. (2000). Directed forgetting of emotional stimuli in borderline personality disorder. Journal of Abnormal Psychology 109, 214–221.Google Scholar
Kroll, J. (1988). The challenge of the borderline patient: Competency in diagnosis and treatment. New York: W.W. Norton.
Kwon, J. S., Kim, J. J., Lee, D. W., Lee, J. S., Lee, D. S., Kim, M. S., et al. (2003). Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive–compulsive disorder. Psychiatry Research 122, 37–47.Google Scholar
LeDoux, J. E. (1994). Emotion, memory and the brain. Scientific American 270, 32–39.Google Scholar
Lenzenweger, M. F., Clarkin, J. F., Fertuck, E. A., & Kernberg, O. F. (2004). Executive neurocognitive functioning and neurobehavioral systems indicators in borderline personality disorder: A preliminary study. Journal of Personality Disorders 18, 421–438.Google Scholar
Levine, D., Marziali, E., & Hood, J. (1997). Emotion processing in borderline personality disorders. The Journal of Nervous and Mental Disease 20, 240–246.Google Scholar
Linehan, M. M. (1993). Cognitive behavioral treatment of borderline personality disorder. New York: Guilford Press.
Lorenz, K. (1935). The companion in the bird's world. The fellow-member of the species as releasing factor of social behavior [Der Kumpan in der Umwelt des Vogels. Der Artgenosse als auslösendes Moment sozialer Verhaltungsweisen]. Unpublished manuscript.
Mahler, M. S. (1975). On the current status of the infantile neurosis. Journal of the American Psychoanalytic Association 23, 327–333.Google Scholar
Main, M. (1996). Introduction to the special section on attachment and psychopathology, Vol. 2: Overview of the field of attachment. Journal of Consulting and Clinical Psychology 64, 237–243.Google Scholar
McNally, R. J., Kaspi, S. P., Riemann, B. C., & Zeitlin, S. B. (1990). Selective processing of threat cues in posttraumatic stress disorder. Journal of Abnormal Psychology 99, 398–402.Google Scholar
Meyer, B., & Pilkonis, P. A. (2005). An attachment model of personality disorder. In M. F. Lenzenweger & J. F. Clarkin (Eds.), Major theories of personality disorder. New York: Guilford Press.
Milner, B., Corkin, S., & Teuber, H. L. (1968). Further analysis of the hippocampal amnesic syndrome: 14 year follow-up study of H.M. Neuropsychologia 6, 215–234.Google Scholar
Mineka, S., & Nugent, K. (1995). Mood congruent memory biases in anxiety and depression. In D. Schacter, J. Coyle, L. Sullivan, M. Mesulam, & G. Fischback, (Eds.), Memory distortion: How minds, brains, and societies reconstruct the past. Cambridge, MA: Harvard University Press.
Nigg, J. T., & Goldsmith, H. H. (1994). Genetics of personality disorders: Perspectives from personality and psychopathology research. Psychological Bulletin 115, 346–380.Google Scholar
O'Leary, K. M., Brouwers, P., Gardner, D. L., & Cowdry, R. W. (1991). Neuropsychological testing of patients with borderline personality disorder. American Journal of Psychiatry 148, 106–111.Google Scholar
Paris, J. (2004). Neurobiological correlates of diagnosis and underlying traits in patients with borderline personality compared with normal controls. Psychiatry Research 121, 239–252.Google Scholar
Piaget, J. (1954). The construction of reality in the child. New York: Basic Books.
Rogan, M. T., & LeDoux, J. E. (1996). Emotion: Systems, cells, synaptic plasticity. Cell 85, 469–475.Google Scholar
Rovee–Collier, C., & Hayne, H. (1987). Reactivation of infant memory: Implications for cognitive development. Advances in Child Development and Behavior 20, 185–238.Google Scholar
Sala, M., Perez, J., Soloff, P., Ucelli di Nemi, S., Caverzasi, E., Soares, J. C., et al. (2004). Stress and hippocampal abnormalities in psychiatric disorders. European Neuropsychopharmacology 14, 393–405.Google Scholar
Schacter, D. L., & Moscovitch, M. (1984). Infants amnesics, and disscoiable memory systems. In M. Moscovitch (Ed.), Infant memory: Its relation to normal and pathological memory in humans and other animals. New York: Plenum Press.
Schmahl, C. G., Vermetten, E., Elzinga, B. M., & Bremner, J. D. (2003). Magnetic resonance imaging of hippocampal and amygdala volume in women with childhood abuse and borderline personality disorder. Psychiatry Research: Neuroimaging 122, 193–198.Google Scholar
Sherry, D. F., & Schacter, D. L. (1987). The evolution of multiple memory systems Psychology Review 94, 439–454.Google Scholar
Soloff, P. H. (2003). Impulsivity and prefrontal hypometabolism in borderline personality disorder. Psychiatry Research: Neuroimaging 123, 153–163.Google Scholar
Sprock, J., Rader, T. J., Kendall, J. P., & Yoder, Y. (2000). Neuropsychological functioning in patients with borderline personality disorder. Journal of Clinical Psychology 56, 1587–1600.Google Scholar
Squire, L. R., Knowlton, B., & Musen, G. (1993). The structure and organization of memory. Annual Review of Psychology 44, 453–495.Google Scholar
Swartz, M., Blazer, D., George, L., & Winfield, I. (1990). Estimating the prevalence of borderline personality disorder in the community. Journal of Personality Disorders 4, 257–272.Google Scholar
Swirsky–Sacchetti, T., Gorton, G., Samuel, S., Sobel, R., Genetta–Wadley, A., & Burleigh, B. (1993). Neuropsychological function in borderline personality disorder. Journal of Clinical Psychology 49, 385–396.Google Scholar
Taylor, S. E., Klein, L. C., Lewis, B. P., Gruenewald, T. L., Gurung, R. A., & Updegraff, J. A. (2000). Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight. Psychology Review 107, 411–429.Google Scholar
Tebartz van Elst, L. (2003). Frontolimbic brain abnormalities in patients with borderline personality disorder: A volumetric magnetic resonance imaging study. Biological Psychiatry 54, 163–171.Google Scholar
Torgerson, S., Kringlen, E., & Cramer, V. (2001). The prevalence of personality disorders in a community setting. Archives of General Psychiatry 58, 590–596.Google Scholar
Tuna, S., Tekcan, A. I., & Topcuoglu, V. (2005). Memory and metamemory in obsessive–compulsive disorder. Behaviour Research and Therapy 43, 15–27.Google Scholar
Vogt, B. A., Finch, D. M., & Olson, C. R. (1992). Functional heterogeneity in cingulate cortex: The anterior executive and posterior evaluative regions. Cerebral Cortex 2, 435–443.Google Scholar
Zanarini, M. C., Frankenburg, F. R., DeLuca, C. J., Hennen, J., Khera, G. S., & Gunderson, J. (1998). The pain of being borderline: Dysphoric states specific to borderline personality disorder. Harvard Review of Psychiatry 6, 201–207.Google Scholar
Zanarini, M. C., Frankenburg, F. R., Dubo, E. D., Sickel, A. E., Trikha, A., Levin, A., et al. (1998). Axis I comorbidity of borderline personality disorder. American Journal of Psychiatry 155, 1733–1739.Google Scholar