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HIV-Related Neurological Syndromes Reduce Health-Related Quality of Life

Published online by Cambridge University Press:  02 December 2014

Rupang Pandya ,
Hartmut B. Krentz ,
M. John Gill ,
Christopher Power  and
M. John Gill
Rupang Pandya
Affiliation:
Department of Psychiatry, University of Calgary, Calgary, AB, Canada
Hartmut B. Krentz
Affiliation:
Department of Anthropology, University of Calgary, Calgary, AB, Canada
M. John Gill
Affiliation:
Department of Medicine, University of Calgary, Calgary, AB, Canada
Christopher Power
Affiliation:
Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada
M. John Gill
Affiliation:
Department of Medicine, University of Calgary, Calgary, AB, Canada
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Abstract:

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Background:

Human immunodeficiency virus (HIV) infection frequently results in neurological complications but the impact of different neurological syndromes on patients' quality of life remains unknown.

Methods:

We investigated health-related quality of life (HRQoL) parameters among HIV/Acquired Immune Deficiency Syndrome (AIDS) patients with and without neurological disease, including 11 dimensions of HRQoL within the Medical Outcomes Short-form Health Survey-HIV.

Results:

Comparisons of sociodemographic and systemic clinical variables did not differ between HIV/AIDS patients with (n=94) and without (n=75) neurological disease. However, patients with neurological diseases exhibited significantly lower HRQoL scores compared to matched controls, which was most evident among HIV/AIDS patients with cognitive impairment and sensory neuropathy. Prospective analysis revealed diminishing HRQoL scores prior to neurological diagnosis followed by a progressive and sustained improvement in HRQoL scores after intervention over a 96-week period.

Conclusions:

These studies indicate that while HIV-related neurological diseases are associated with reduced HRQoL scores, enhanced neurological care has a positive impact on HIV/AIDS patients' overall well-being.

Résumé:

RÉSUMÉ:Introduction:

L’infection par le virus de l’immunodéficience humaine (VIH) comporte des complications neurologiques et l’impact de différents syndromes neurologiques sur la qualité de vie des patients atteints demeure inconnu.

Méthodes:

Nous avons évalué des paramètres de la qualité de vie reliés à la santé (QVRS) chez des patients porteurs du VIH/SIDA, avec et sans maladie neurologique, dont 11 mesures de la QVRS du Medical Outcomes Short-form Health Survey-HIV.

Résultats:

Il n’existait pas de différence entre les patients atteints de VIH/SIDA avec (n = 94) ou sans (n = 75) maladie neurologique quant aux variables sociodémographiques et cliniques systémiques. Cependant les patients atteints de maladies neurologiques avaient des scores significativement plus faibles pour la QVRS par rapport à des témoins appariés. Cette différence était plus marquée chez les patients atteints de VIH/SIDA qui présentaient une atteinte cognitive et une neuropathie sensitive. Une analyse prospective a montré des scores de la QVRS plus faibles avant le diagnostic neurologique et une amélioration progressive soutenue des scores après intervention sur une période de 96 semaines.

Conclusions:

Bien que les maladies neurologiques reliées au VIH soient associées à des scores plus bas à l’évaluation de la QVRS, ces études indiquent que des soins neurologiques adéquats ont un impact positif sur le bien-être général des patients atteints de VIH/SIDA.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 32 , Issue 2 , May 2005 , pp. 201 - 204
Copyright
Copyright © The Canadian Journal of Neurological 2005

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