Hostname: page-component-848d4c4894-nr4z6 Total loading time: 0 Render date: 2024-05-04T12:29:03.032Z Has data issue: false hasContentIssue false

Prevalence of depression and burden among informal care-givers of people with dementia: a meta-analysis

Published online by Cambridge University Press:  06 June 2019

Rebecca N. Collins*
Affiliation:
Department of Clinical Psychology, University of East Anglia, Norwich, UK
Naoko Kishita
Affiliation:
School of Health Sciences, University of East Anglia, Norwich, UK
*
*Corresponding author. Email: bctalks7@hotmail.com

Abstract

This meta-analysis examined the prevalence of depression and burden among informal care-givers of people with dementia (PwD) and compared the prevalence of depression between male and female, and spousal and non-spousal, care-givers. The quality of studies was evaluated and moderator variables explored. A search of six electronic databases (PsycARTICLES, PsycINFO, MEDLINE Complete, SCOPUS, Web of Science and ProQuest) was conducted from the first available date to the 31 October 2017. Inclusion criteria involved observational studies on the prevalence of burden or depression among informal care-givers of PwD. Forty-three studies were examined with a total of 16,911 participants. The adjusted pooled prevalence of depression was 31.24 per cent (95% confidence interval (CI) = 27.70, 35.01) and burden was 49.26 per cent (95% CI = 37.15, 61.46), although heterogeneity among prevalence estimates was high. Depression prevalence estimates differed according to the instrument used and the continent where the study was conducted. The odds of having depression were almost one and a half times higher in female compared to male care-givers. No significant difference was observed between spouses and non-spouses. Most studies had a medium risk of bias. Results suggest a great need within this population for interventions that are effective at reducing burden and depressive symptoms. It therefore appears imperative for dementia services that are not providing such interventions to do so.

Type
Review Article
Copyright
Copyright © Cambridge University Press 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Adams, B, Aranda, MP, Kemp, B and Takagi, K (2002) Ethnic and gender differences in distress among Anglo American, African American, Japanese American, and Mexican American spousal caregivers of persons with dementia. Journal of Clinical Geropsychology 8, 279301.CrossRefGoogle Scholar
Alzheimer's Disease International (2013) World Alzheimer's Report 2013: An Analysis of Long-term Care for Dementia. Available at https://www.alz.co.uk/research/WorldAlzheimerReport2013.pdf.Google Scholar
Alzheimer's Disease International (2015) World Alzheimer's Report 2015. The Global Impact of Dementia: An Analysis of Prevalence, Incidence, Cost and Trends. Available at https://www.alz.co.uk/research/world-report-2015.Google Scholar
Alzheimer's Research UK (2015) Women and Dementia: A Marginalised Majority. Available at https://www.alzheimersresearchuk.org/wp-content/uploads/2015/03/Women-and-Dementia-A-Marginalised-Majority1.pdf.Google Scholar
Alzheimer's Society (2014) Care for Today and Cure for Tomorrow: Alzheimer's Society Strategy for Funding Research 20142017. Available at https://www.alzheimers.org.uk/download/downloads/id/2254/care_for_today_and_cure_for_tomorrow.pdf.Google Scholar
American Psychiatric Association (APA) (1980) Diagnostic and Statistical Manual of Mental Disorders, 3rd Edn.Washington, DC: American Psychiatric Publishing.Google Scholar
American Psychiatric Association (APA) (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd Edn Text Revision. Washington, DC: American Psychiatric Publishing.Google Scholar
American Psychiatric Association (APA) (1994) Diagnostic and Statistical Manual of Mental Disorders, 4th Edn. Washington, DC: American Psychiatric Publishing.Google Scholar
American Psychiatric Association (APA) (2000) Diagnostic and Statistical Manual of Mental Disorders, 4th Edn Text Revision. Washington, DC: American Psychiatric Publishing.Google Scholar
American Psychiatric Association (APA) (2013) Diagnostic and Statistical Manual of Mental Disorders, 5th Edn.Washington, DC: American Psychiatric Publishing.Google Scholar
Andresen, EM, Malmgren, JA, Carter, WB and Patrick, DL (1994) Screening for depression in well older adults: evaluation of a short form of the CES-D (Center for Epidemiologic Studies Depression Scale). American Journal of Preventive Medicine 10, 7784.CrossRefGoogle Scholar
Arango Lasprilla, JC, Moreno, A, Rogers, H and Francis, K (2009) The effect of dementia patient's physical, cognitive, and emotional/behavioral problems on caregiver well-being: findings from a Spanish-speaking sample from Colombia, South America. American Journal of Alzheimer's Disease & Other Dementias 24, 384395.CrossRefGoogle ScholarPubMed
Beck, AT and Beck, RW (1972) Screening depressed patients in family practice: a rapid technique. Postgraduate Medicine 52, 8185.CrossRefGoogle Scholar
Beck, AT, Steer, RA, Ball, R and Ranieri, W (1996) Comparison of Beck Depression Inventories-IA and -II in psychiatric outpatients. Journal of Personality Assessment 67, 588597.CrossRefGoogle ScholarPubMed
Beck, AT, Ward, CH, Mendelson, M, Mock, J and Erbaugh, J (1961) An inventory for measuring depression. Archives of General Psychiatry 4, 561571.Google ScholarPubMed
Bednarek, A, Mojs, E, Krawczyk-Wasielewska, A, Głodowska, K, Samborski, W, Lisiński, P, Kopczyński, P, Gregersen, R and Millán-Calenti, JC (2016) Correlation between depression and burden observed in informal caregivers of people suffering from dementia with time spent on caregiving and dementia severity. European Review for Medical and Pharmacological Sciences 20, 5963.Google ScholarPubMed
Bejjani, C, Snow, AL, Judge, KS, Bass, DM, Morgan, RO, Wilson, N, Walder, A, Looman, WJ, McCarthy, C and Kunik, ME (2015) Characteristics of depressed caregivers of veterans with dementia. American Journal of Alzheimer's Disease & Other Dementias 30, 672678.CrossRefGoogle ScholarPubMed
Berger, G, Bernhardt, T, Weimer, E, Peters, J, Kratzsch, T and Frolich, L (2005) Longitudinal study on the relationship between symptomatology of dementia and levels of subjective burden and depression among family caregivers in memory clinic patients. Journal of Geriatric Psychiatry and Neurology 18, 119128.CrossRefGoogle ScholarPubMed
Borenstein, M, Hedges, L, Higgins, J and Rothstein, H (2005) Comprehensive Meta-analysis (Version 2). Englewood, NJ: Biostat.Google Scholar
Borenstein, M, Hedges, LV, Higgins, J and Rothstein, HR (2009) Introduction to Meta-Analysis. Chichester, UK: John Wiley & Sons.CrossRefGoogle Scholar
Borsje, P, Hems, MA, Lucassen, PL, Bor, H, Koopmans, RT and Pot, AM (2016) Psychological distress in informal caregivers of patients with dementia in primary care: course and determinants. Family Practice 33, 374381.CrossRefGoogle ScholarPubMed
Breinbauer, H, Vásquez, H, Mayanz, S, Guerra, C and Millán, T (2009) Validación en Chile de la Escala de Sobrecarga del Cuidador de Zarit en sus versiones original y abreviada. Revista Médica de Chile 137, 657665.CrossRefGoogle Scholar
Brodaty, H and Donkin, M (2009) Family caregivers of people with dementia. Dialogues in Clinical Neuroscience 11, 217.Google ScholarPubMed
Brodaty, H, Thomson, C, Thompson, C and Fine, M (2005) Why caregivers of people with dementia and memory loss don't use services. International Journal of Geriatric Psychiatry 20, 537546.CrossRefGoogle ScholarPubMed
Brodaty, H, Woodward, M, Boundy, K, Ames, D, Balshaw, R and PRIME Study Group (2014) Prevalence and predictors of burden in caregivers of people with dementia. American Journal of Geriatric Psychiatry 22, 756765.CrossRefGoogle ScholarPubMed
Brooker, D (2017) How Has the Field of Dementia Care Changed in the Past 30 Years? Available at http://www.jkp.com/jkpblog/2017/05/dementia-field-changes-30-years.Google Scholar
Caspar, S and O'Rourke, N (2009) The composition and structure of depressive symptomatology among young and older caregivers of persons with dementia. Ageing International 34, 3341.CrossRefGoogle Scholar
Chan, YF, Leung, DY, Fong, DY, Leung, CM and Lee, AM (2010) Psychometric evaluation of the Hospital Anxiety and Depression Scale in a large community sample of adolescents in Hong Kong. Quality of Life Research 19, 865873.CrossRefGoogle Scholar
Cheng, ST, Lam, LC and Kwok, T (2013) Neuropsychiatric symptom clusters of Alzheimer disease in Hong Kong Chinese: correlates with caregiver burden and depression. American Journal of Geriatric Psychiatry 21, 10291037.CrossRefGoogle Scholar
Chiao, CY, Wu, HS and Hsiao, CY (2015) Caregiver burden for informal caregivers of patients with dementia: a systematic review. International Nursing Review 62, 340350.Google ScholarPubMed
Cohen, J (1960) A coefficient of agreement for nominal scales. Educational and Psychological Measurement 20, 3746.CrossRefGoogle Scholar
Cohen, CA, Colantonio, A and Vernich, L (2002) Positive aspects of caregiving: rounding out the caregiver experience. International Journal of Geriatric Psychiatry 17, 184188.CrossRefGoogle ScholarPubMed
Collins, RN, Gilligan, LJ and Poz, R (2018) The evaluation of a compassion-focused therapy group for couples experiencing a dementia diagnosis. Clinical Gerontologist 41, 474486.CrossRefGoogle Scholar
Conde, C and Useros, E (1975) Adaptación castellana de la escala de evaluación conductual para la depresión de Beck. Revista de Psiquiatría y Psicología Médica de Europa y América Latinas 12, 217236.Google Scholar
Contador, I, Fernández-Calvo, B, Palenzuela, DL, Miguéis, S and Ramos, F (2012) Prediction of burden in family caregivers of patients with dementia: a perspective of optimism based on generalized expectancies of control. Aging & Mental Health 16, 675682.CrossRefGoogle ScholarPubMed
Copas, J and Shi, JQ (2000) Meta-analysis, funnel plots and sensitivity analysis. Biostatistics 1, 247262.CrossRefGoogle ScholarPubMed
Covinsky, KE, Newcomer, R, Fox, P, Wood, J, Sands, L, Dane, K and Yaffe, K (2003) Patient and caregiver characteristics associated with depression in caregivers of patients with dementia. Journal of General Internal Medicine 18, 10061014.CrossRefGoogle ScholarPubMed
Cucciare, MA, Gray, H, Azar, A, Jimenez, D and Gallagher-Thompson, D (2010) Exploring the relationship between physical health, depressive symptoms, and depression diagnoses in Hispanic dementia caregivers. Aging & Mental Health 14, 274282.CrossRefGoogle ScholarPubMed
Cuijpers, P (2005) Depressive disorders in caregivers of dementia patients: a systematic review. Aging & Mental Health 9, 325330.CrossRefGoogle ScholarPubMed
Dilworth-Anderson, P and Anderson, N (1994) Dementia caregiving in blacks: a contextual approach to research. In Light, E, Niederehe, G and Lebowitz, B (eds), Stress Effects on Family Caregivers of Alzheimer's Patients. New York, NY: Springer, pp. 385409.Google Scholar
Duval, S and Tweedie, R (2000) Trim and fill: a simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysis. Biometrics 56, 455463.CrossRefGoogle ScholarPubMed
Epstein-Lubow, G, Davis, JD, Miller, IW and Tremont, G (2008) Persisting burden predicts depressive symptoms in dementia caregivers. Journal of Geriatric Psychiatry and Neurology 21, 198203.CrossRefGoogle ScholarPubMed
Etters, L, Goodall, D and Harrison, BE (2008) Caregiver burden among dementia patient caregivers: a review of the literature. Journal of the American Association of Nurse Practitioners 20, 423428.CrossRefGoogle ScholarPubMed
Fauth, E, Hess, K, Piercy, K, Norton, M, Corcoran, C, Rabins, P, Lyketsos, C and Tschanz, J (2012) Caregivers’ relationship closeness with the person with dementia predicts both positive and negative outcomes for caregivers’ physical health and psychological well-being. Aging & Mental Health 16, 699711.Google ScholarPubMed
First, MB, Spitzer, RL, Gibbon, M and Williams, JBW (2008) Structured clinical interview for DSM-IV axis I disorders – clinician version (SCID-I). In Rush, AJ, First, MB and Blacker, D (eds), Handbook of Psychiatric Measures, 2nd Edn.Washington, DC: American Psychiatric Publishing, pp. 4043.Google Scholar
Folstein, MF, Folstein, SE and McHugh, PR (1975) ‘Mini-mental state’: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research 12, 189198.CrossRefGoogle Scholar
Gallagher, D, Ni Mhaolain, A, Crosby, L, Ryan, D, Lacey, L, Coen, RF, Walsh, C, Coakley, D, Walsh, JB, Cunningham, C and Lawlor, BA (2011) Self-efficacy for managing dementia may protect against burden and depression in Alzheimer's caregivers. Aging & Mental Health 15, 663670.CrossRefGoogle ScholarPubMed
Gallagher, D, Rose, J, Rivera, P, Lovett, S and Thompson, LW (1989) Prevalence of depression in family caregivers. The Gerontologist 29, 449456.CrossRefGoogle ScholarPubMed
García-Alberca, JM, Cruz, B, Lara, JP, Garrido, V, Gris, E, Lara, A and Castilla, C (2012) Disengagement coping partially mediates the relationship between caregiver burden and anxiety and depression in caregivers of people with Alzheimer's disease. Results from the MÁLAGA-AD study. Journal of Affective Disorders 136, 848856.CrossRefGoogle ScholarPubMed
Gaugler, JE, Kane, RL, Kane, RA and Newcomer, R (2005) Unmet care needs and key outcomes in dementia. Journal of the American Geriatrics Society 53, 20982105.CrossRefGoogle ScholarPubMed
Germain, S, Adam, S, Olivier, C, Cash, H, Ousset, PJ, Andrieu, S, Vellas, B, Meulemans, T, Reynish, E and Salmon, E (2009) Does cognitive impairment influence burden in caregivers of patients with Alzheimer's disease? Journal of Alzheimer's Disease 17, 105114.CrossRefGoogle ScholarPubMed
Given, CW, Given, B, Azzouz, F, Kozachik, S and Stommel, M (2001) Predictors of pain and fatigue in the year following diagnosis among elderly cancer patients. Journal of Pain Symptom Management 21, 456466.CrossRefGoogle ScholarPubMed
Givens, JL, Mezzacappa, C, Heeren, T, Yaffe, K and Fredman, L (2014) Depressive symptoms among dementia caregivers: role of mediating factors. American Journal of Geriatric Psychiatry 22, 481488.CrossRefGoogle ScholarPubMed
Goldberg, D, Bridges, K, Duncan-Jones, P and Grayson, D (1988) Detecting anxiety and depression in general medical settings. British Medical Journal 97, 897899.CrossRefGoogle Scholar
Hamilton, M (1980) Rating depressive patients. Journal of Clinical Psychiatry 41, 2124.Google ScholarPubMed
Harbord, R (2010) Investigating heterogeneity: sub-group analysis and meta-regression. PowerPoint slides. Available at http://methods.cochrane.org/sites/methods.cochrane.org.statistics/files/public/uploads/SMG_training_course_cardiff/2010_SMG_training_cardiff_day1_session4_harbord.pdf.Google Scholar
Hasegawa, N, Hashimoto, M, Koyama, A, Ishikawa, T, Yatabe, Y, Honda, K, Yuuki, S, Araki, K and Ikeda, M (2014) Patient-related factors associated with depressive state in caregivers of patients with dementia at home. Journal of the American Medical Directors Association 15, 371.e15317.e18.CrossRefGoogle Scholar
Hays, JC, Blazer, DG and Gold, DT (1993) CES-D: cutpoint or change score? Journal of the American Geriatrics Society 41, 344345.CrossRefGoogle ScholarPubMed
Higgins, JPT and Thompson, SG (2002) Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 21, 15391558.CrossRefGoogle ScholarPubMed
Higgins, JPT, Thompson, SG, Deeks, JJ and Altman, DG (2003) Measuring inconsistency in meta-analyses. British Medical Journal 327, 557.CrossRefGoogle ScholarPubMed
Holland, JM, Thompson, LW, Tzuang, M and Gallagher-Thompson, D (2010) Psychosocial factors among Chinese American women dementia caregivers and their association with salivary cortisol: results of an exploratory study. Ageing International 35, 109127.CrossRefGoogle Scholar
Hoppes, S, Bryce, H, Hellman, C and Finlay, E (2012) The effects of brief mindfulness training on caregivers’ well-being. Activities, Adaptation & Aging 36, 147166.Google Scholar
Hughes, CP, Berg, L, Danziger, WL, Coben, LA and Martin, R (1982) A new clinical scale for the staging of dementia. British Journal of Psychiatry 140, 566572.CrossRefGoogle ScholarPubMed
Jang, Y, Clay, OJ, Roth, DL, Haley, WE and Mittelman, MS (2004) Neuroticism and longitudinal change in caregiver depression: impact of a spouse–caregiver intervention program. The Gerontologist 44, 311317.CrossRefGoogle ScholarPubMed
Joling, KJ, O'Dwyer, ST, Hertogh, CM and Hout, HP (2018) The occurrence and persistence of thoughts of suicide, self-harm and death in family caregivers of people with dementia: a longitudinal data analysis over 2 years. International Journal of Geriatric Psychiatry 33, 263270.CrossRefGoogle ScholarPubMed
Kaiser, S and Panegyres, PK (2007) The psychosocial impact of young onset dementia on spouses. American Journal of Alzheimer's Disease & Other Dementias 21, 398402.CrossRefGoogle Scholar
Kemp, BJ and Adams, B (1995) The Older Adult Health and Mood Questionnaire: a measure of geriatric depressive disorder. Journal of Geriatric Psychiatry and Neurology 8, 162167.CrossRefGoogle ScholarPubMed
Kramer, BJ (1993) Marital history and the prior relationship as predictors of positive and negative outcomes among wife caregivers. Family Relations 42, 367375.CrossRefGoogle Scholar
Krebber, AMH, Buffart, LM, Kleijn, G, Riepma, IC, Bree, R, Leemans, CR, Becker, A, Brug, J, Straten, A, Cuijpers, P and Verdonck-de Leeuw, IM (2014) Prevalence of depression in cancer patients: a meta-analysis of diagnostic interviews and self report instruments. Psycho-Oncology 23, 121130.CrossRefGoogle ScholarPubMed
Kroenke, K, Spitzer, RL and Williams, JB (2001) The PHQ9: validity of a brief depression severity measure. Journal of General Internal Medicine 16, 606613.Google Scholar
Kurz, X, Scuvée-Moreau, J, Vernooij-Dassen, M and Dresse, A (2003) Cognitive impairment, dementia and quality of life. Acta Neurologica Belgica 103, 2434.Google ScholarPubMed
Laidlaw, K (2015) Cognitive Behaviour Therapy for Older People: An Introduction. London: Sage.CrossRefGoogle Scholar
Li, D, Zhang, DJ, Shao, JJ, Qi, XD and Tian, L (2014) A meta-analysis of the prevalence of depressive symptoms in Chinese older adults. Archives of Gerontology and Geriatrics 58, 19.CrossRefGoogle ScholarPubMed
Liang, X, Guo, Q, Luo, J, Li, F, Ding, D, Zhao, Q and Hong, Z (2016) Anxiety and depression symptoms among caregivers of care-recipients with subjective cognitive decline and cognitive impairment. BMC Neurology 16, 191.CrossRefGoogle ScholarPubMed
Lowery, K, Mynt, P, Aisbett, J, Dixon, T, O'Brien, J and Ballard, C (2000) Depression in the carers of dementia sufferers: a comparison of the carers of patients suffering from dementia with Lewy bodies and the carers of patients with Alzheimer's disease. Journal of Affective Disorders 59, 6165.CrossRefGoogle ScholarPubMed
Lu, YYF and Austrom, MG (2005) Distress responses and self-care behaviors in dementia family caregivers with high and low depressed mood. Journal of the American Psychiatric Nurses Association 11, 231240.Google Scholar
Luchsinger, JA, Tipiani, D, Torres-Patiño, G, Silver, S, Eimicke, JP, Ramirez, M, Teresi, J and Mittelman, M (2015) Characteristics and mental health of hispanic dementia caregivers in New York City. American Journal of Alzheimer's Disease & Other Dementias 30, 584590.CrossRefGoogle ScholarPubMed
Luppa, M, Sikorski, C, Luck, T, Ehreke, L, Konnopka, A, Wiese, B, Weyerer, S, König, HH and Riedel-Heller, SG (2012) Age- and gender-specific prevalence of depression in latest-life – systematic review and meta-analysis. Journal of Affective Disorders 136, 212221.CrossRefGoogle ScholarPubMed
Mahoney, R, Regan, C, Katona, C and Livingston, G (2005) Anxiety and depression in family caregivers of people with Alzheimer disease: the LASER-AD study. American Journal of Geriatric Psychiatry 13, 795801.CrossRefGoogle ScholarPubMed
Martín, M, Salvadór, I, Nadal, S, Miji, L, Rico, J, Lanz, P and Taussig, M (1996) Adaptación para nuestro medio de la Escala de Sobrecarga del Cuidador (Caregiver Burden Interview) de Zarit. Revista de Gerontología 6, 338346.Google Scholar
McConaghy, R and Caltabiano, ML (2005) Caring for a person with dementia: exploring relationships between perceived burden, depression, coping and well-being. Nursing & Health Sciences 7, 8191.CrossRefGoogle ScholarPubMed
McKhann, G, Drachman, D, Folstein, M, Katzman, R, Price, D and Stadlan, EM (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34, 939944.CrossRefGoogle ScholarPubMed
Medrano, M, Rosario, RL, Payano, AN and Capellán, NR (2014) Burden, anxiety and depression in caregivers of Alzheimer patients in the Dominican Republic. Dementia & Neuropsychologia 8, 384388.CrossRefGoogle ScholarPubMed
Mitchell, AJ, Chan, M, Bhatti, H, Halton, M, Grassi, L, Johansen, C and Meader, N (2011) Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: a meta-analysis of 94 interview-based studies. The Lancet Oncology 12, 160174.CrossRefGoogle ScholarPubMed
Mitchell, AJ, Vaze, A and Rao, S (2009) Clinical diagnosis of depression in primary care: a meta-analysis. The Lancet 374, 609619.CrossRefGoogle ScholarPubMed
Moher, D, Liberati, A, Tetzlaff, J, Altman, DG and Prisma Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLOS Medicine 6, e1000097.CrossRefGoogle ScholarPubMed
Montgomery, SA and Asberg, M (1979) A new depression scale designed to be sensitive to change. British Journal of Psychiatry 134, 382389.CrossRefGoogle ScholarPubMed
Morris, RG, Morris, LW and Britton, PG (1998) Factors affecting the emotional well-being of caregivers of dementia sufferers. British Journal of Psychiatry 153, 147156.CrossRefGoogle Scholar
Munn, Z, Moola, S, Lisy, K and Riitano, D (2014) The Joanna Briggs Institute Reviewer's Manual 2014: The Systematic Review of Prevalence and Incidence Data. Adelaide, Australia: The Joanna Briggs Institute.Google Scholar
Novak, M and Guest, C (1989) Application of a multidimensional caregiver burden inventory. The Gerontologist 29, 798803.CrossRefGoogle ScholarPubMed
O'Brien, E (2016) Alzheimer's Diagnosis Can Mean Steep Costs for Family Caregivers. Available at http://time.com/money/4501444/alzheimers-family-caregivers-steep-costs/.Google Scholar
O'Dwyer, ST, Moyle, W, Zimmer-Gembeck, M and De Leo, D (2013) Suicidal ideation in family carers of people with dementia: a pilot study. International Journal of Geriatric Psychiatry 28, 11821188.Google ScholarPubMed
O'Dwyer, ST, Moyle, W, Zimmer-Gembeck, M and De Leo, D (2016) Suicidal ideation in family carers of people with dementia. Aging & Mental Health 20, 222230.CrossRefGoogle ScholarPubMed
Orgeta, V and Lo Sterzo, E (2013) Sense of coherence, burden, and affective symptoms in family carers of people with dementia. International Psychogeriatrics 25, 973980.CrossRefGoogle ScholarPubMed
Ornstein, K and Gaugler, JE (2012) The problem with ‘problem behaviors’: a systematic review of the association between individual patient behavioral and psychological symptoms and caregiver depression and burden within the dementia patient–caregiver dyad. International Psychogeriatrics 24, 15361552.CrossRefGoogle Scholar
Ory, MG, Hoffman III, RR, Yee, JL, Tennstedt, S and Schulz, R (1999) Prevalence and impact of caregiving: a detailed comparison between dementia and non dementia caregivers. The Gerontologist 39, 177186.CrossRefGoogle Scholar
Ostojić, D, Vidović, D, Baceković, A, Brecić, P and Jukić, V (2014) Prevalence of anxiety and depression in caregivers of Alzheimer's dementia patients. Acta Clinica Croatica 53, 1721.Google Scholar
Piercy, KW, Fauth, EB, Norton, MC, Pfister, R, Corcoran, CD, Rabins, PV, Lyketsos, C and Tschanz, JT (2013) Predictors of dementia caregiver depressive symptoms in a population: the Cache County dementia progression study. Journals of Gerontology: Psychological Sciences and Social Sciences 68B, 921926.CrossRefGoogle Scholar
Pinquart, M and Sörensen, S (2003) Differences between caregivers and non caregivers in psychological health and physical health: a meta-analysis. Psychology and Aging 18, 250267.CrossRefGoogle Scholar
Pruchno, RA, Brill, JE, Shands, Y, Gordon, JR, Genderson, MW, Rose, M and Cartwright, F (2008) Convenience samples and caregiving research: how generalizable are the findings? The Gerontologist 48, 820827.CrossRefGoogle ScholarPubMed
Radloff, LS (1977) The CES-D scale: a self-report depression scale for research in the general population. Applied Psychological Measurement 1, 385401.CrossRefGoogle Scholar
Raggi, A, Tasca, D, Panerai, S, Neri, W and Ferri, R (2015) The burden of distress and related coping processes in family caregivers of patients with Alzheimer's disease living in the community. Journal of the Neurological Sciences 358, 7781.CrossRefGoogle ScholarPubMed
Ramos-Brieva, JC (1986) Validacion de la versión castellana de la escala de Hamilton para la depresión. Actas Luso-Españolas de Neurología, Psiquiatría y Ciencias Afines 6, 324334.Google Scholar
Riedel, O, Klotsche, J and Wittchen, HU (2016) Overlooking informal dementia caregivers’ burden. Research in Gerontological Nursing 9, 167174.CrossRefGoogle ScholarPubMed
Roche, L, Croot, K, MacCann, C, Cramer, B and Diehl-Schmid, J (2015) The role of coping strategies in psychological outcomes for frontotemporal dementia caregivers. Journal of Geriatric Psychiatry and Neurology 28, 218228.CrossRefGoogle Scholar
Rosenthal, R (1979) The file drawer problem and tolerance for null results. Psychological Bulletin 86, 638–341.CrossRefGoogle Scholar
Rosness, TA, Mjørud, M and Engedal, K (2011) Quality of life and depression in carers of patients with early onset dementia. Aging & Mental Health 15, 299306.CrossRefGoogle ScholarPubMed
Roth, DL, Ackerman, ML, Okonkwo, OC and Burgio, LD (2008) The four-factor model of depressive symptoms in dementia caregivers: a structural equation model of ethnic differences. Psychology and Aging 23, 567576.CrossRefGoogle ScholarPubMed
Roth, M, Tym, E, Mountjoy, CQ, Huppert, FA, Hendrie, H, Verma, S, and Goddard, R (1986) CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. British Journal of Psychiatry 149, 698709.CrossRefGoogle Scholar
Sallim, AB, Sayampanathan, AA, Cuttilan, A and Ho, RCM (2015) Prevalence of mental health disorders among caregivers of patients with Alzheimer disease. Journal of the American Medical Directors Association 16, 10341041.CrossRefGoogle ScholarPubMed
Sansoni, J, Vellone, E and Piras, G (2004) Anxiety and depression in community-dwelling, Italian Alzheimer's disease caregivers. International Journal of Nursing Practice 10, 93100.CrossRefGoogle ScholarPubMed
Schulz, R and Martire, LM (2004) Family caregiving of persons with dementia: prevalence, health effects, and support strategies. American Journal of Geriatric Psychiatry 12, 240249.CrossRefGoogle ScholarPubMed
Simpson, CE (2010) Sleep: Effect on Dementia Caregiver Mastery, Perceived Stress and Depression (Unpublished doctoral dissertation). The University of Texas at Austin, Austin, TX.Google Scholar
Slachevsky, A, Budinich, M, Miranda-Castillo, C, Nunez-Huasaf, J, Silva, JR, Munoz-Neira, C, Gloger, S, Jimenez, O, Martorell, B and Delgado, C (2013) The CUIDEME Study: determinants of burden in Chilean primary caregivers of patients with dementia. Journal of Alzheimer's Disease 35, 297306.CrossRefGoogle ScholarPubMed
Sleath, B, Thorpe, J, Landerman, LR, Doyle, M and Clipp, E (2005) African-American and white caregivers of older adults with dementia: differences in depressive symptomatology and psychotropic drug use. Journal of the American Geriatrics Society 53, 397404.CrossRefGoogle ScholarPubMed
Spector, A, Thorgrimsen, L, Woods, B, Royan, L, Davies, S, Butterworth, M and Orrell, M (2003) Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia. British Journal of Psychiatry 183, 248254.CrossRefGoogle ScholarPubMed
Spitzer, RL and Robins, E (1978) Research diagnostic criteria: rationale and reliability. Archives of General Psychiatry 35, 773782.CrossRefGoogle ScholarPubMed
Taylor Nelson Sofres British Market Research Bureau (2014) Attitudes to Mental Illness: 2013 Research Report. Available at https://www.mind.org.uk/news-campaigns/news/survey-shows-greatest-improvement-in-public-attitudes-to-mental-health-in-20-years/#.WmUMqKhl-00.Google Scholar
Välimäki, TH, Martikainen, JA, Hallikainen, IT, Väätäinen, ST and Koivisto, AM (2015) Depressed spousal caregivers have psychological stress unrelated to the progression of Alzheimer disease: a 3-year follow-up report, Kuopio ALSOVA study. Journal of Geriatric Psychiatry and Neurology 28, 272280.CrossRefGoogle ScholarPubMed
Vitaliano, PP (1997) Physiological and physical concomitants of caregiving: introduction to special issue. Annals of Behavioral Medicine 19, 7577.CrossRefGoogle Scholar
Vitaliano, PP, Young, HM and Russo, J (1991) Burden: a review of measures used among caregivers of individuals with dementia. The Gerontologist 31, 6775.CrossRefGoogle ScholarPubMed
Waite, A, Bebbington, P, Skelton-Robinson, M and Orrell, M (2004) Social factors and depression in carers of people with dementia. International Journal of Geriatric Psychiatry 19, 582587.CrossRefGoogle ScholarPubMed
Wang, J, Wu, X, Lai, W, Long, E, Zhang, X, Li, W, Zhu, Y, Chen, C, Zhong, X, Liu, Z and Wang, D (2017) Prevalence of depression and depressive symptoms among outpatients: a systematic review and meta-analysis. BMJ Open 7, 017173.CrossRefGoogle ScholarPubMed
Williams, IC (2005) Emotional health of black and white dementia caregivers: a contextual examination. Journals of Gerontology: Psychological Sciences and Social Sciences 60B, 287295.CrossRefGoogle Scholar
Williamson, GM and Schulz, R (1993) Coping with specific stressors in Alzheimer's disease caregiving. The Gerontologist 33, 747755.CrossRefGoogle ScholarPubMed
Wittchen, HU, Höfler, M and Meister, W (2001) Prevalence and recognition of depressive syndromes in German primary care settings: poorly recognized and treated? International Clinical Psychopharmacology 16, 121135.CrossRefGoogle ScholarPubMed
World Health Organization (WHO) (1978) The ICD-9 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Geneva: WHO.Google Scholar
World Health Organization (WHO) (1992) The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Geneva: WHO.Google Scholar
World Health Organization (WHO) (2003) International Classification of Primary Care, Second Edition (ICPC-2). Available at http://www.who.int/classifications/icd/adaptations/icpc2/en/index.Google Scholar
World Health Organization (WHO) (2017) Depression and Other Common Mental Disorders: Global Health Estimates. Geneva: WHO Document Production Services.Google Scholar
Yesavage, JA and Sheikh, JI (1986) Geriatric depression scale (GDS) recent evidence and development of a shorter version. Clinical Gerontologist 5, 165173.CrossRefGoogle Scholar
Yesavage, JA, Brink, TL, Rose, TL, Lum, O, Huang, V, Adey, M and Leirer, VO (1983) Development and validation of a geriatric depression screening scale: a preliminary report. Journal of Psychiatric Research 17, 3749.CrossRefGoogle Scholar
Zarit, SH, Reever, KE and Back-Peterson, J (1980) Relatives of the impaired elderly: correlates of feelings of burden. The Gerontologist 20, 649655.CrossRefGoogle ScholarPubMed
Zarit, SH, Todd, PA and Zarit, JM (1986) Subjective burden of husbands and wives as caregivers: a longitudinal study. The Gerontologist 26, 260266.CrossRefGoogle ScholarPubMed
Zigmond, AS and Snaith, RP (1983) The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica 67, 361370.CrossRefGoogle ScholarPubMed
Supplementary material: File

Collins and Kishita supplementary material

Collins and Kishita supplementary material 1

Download Collins and Kishita supplementary material(File)
File 20.1 KB