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Self-rating scales assessing subjective well-being and distress correlate with rCBF in PTSD-sensitive regions

Published online by Cambridge University Press:  15 June 2011

D. Nardo ,
G. Högberg ,
F. Flumeri ,
H. Jacobsson ,
S. A. Larsson ,
T. Hällström  and
M. Pagani
D. Nardo*
Affiliation:
Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy
G. Högberg
Affiliation:
Department of Clinical Neuroscience, Section for Psychiatry, Huddinge, Karolinska Institute, Stockholm, Sweden
F. Flumeri
Affiliation:
Department of Psychology, University of Rome La Sapienza, Rome, Italy
H. Jacobsson
Affiliation:
Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden
S. A. Larsson
Affiliation:
Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden
T. Hällström
Affiliation:
Department of Clinical Neuroscience, Section for Psychiatry, Huddinge, Karolinska Institute, Stockholm, Sweden
M. Pagani
Affiliation:
Department of Nuclear Medicine, Karolinska Hospital, Stockholm, Sweden Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy
*
*Address for correspondence: Dr D. Nardo, Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy. (Email: davidenardo@gmail.com)
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Abstract

Background

The aim of this study was to investigate the distribution of the regional cerebral blood flow (rCBF) in occupational-related post-traumatic stress disorder (PTSD) subjects and to seek possible correlations between brain perfusion and self-rating scales (SRS) in order to cross-check their diagnostic value and to look for their neural correlates.

Method

A total of 13 traumatized underground and long-distance train drivers developing (S) and 17 not developing (NS) PTSD who had experienced a ‘person under train’ accident or who had been assaulted at work underwent clinical assessment and 99mTc-HMPAO SPECT imaging during autobiographical trauma scripts. Statistical parametric mapping was applied to analyse rCBF changes in S as compared with NS and to search for correlations between rCBF and the administered SRS scores, modelling age, months to SPECT and the ratio ‘grey matter/intra-cranial volume’ as nuisance variables.

Results

Significantly higher activity was observed during trauma script in left posterior and anterior insula, posterior cingulate, inferior parietal lobule, precuneus, caudate and putamen in PTSD subjects as compared with the trauma-exposed control group. Impact of Event Scale and World Health Organisation (10) Well-Being Index scores highly correlated with tracer uptake to a great extent in the same regions in which rCBF differences between S and NS were found.

Conclusions

These findings support the involvement of insular, cingulate and parietal cortices (as well as the basal ganglia) in the pathogenesis of PTSD and in the processing of related subjective well-being and distress.

Keywords

Impact of Event ScalePTSDrCBFSPECTsubjective distresssubjective well-beingWell-Being Index
Type
Original Articles
Information
Psychological Medicine , Volume 41 , Issue 12 , December 2011 , pp. 2549 - 2561
Copyright
Copyright © Cambridge University Press 2011

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References

APA (1994). Diagnostic and Statistical Manual of Mental Disorders, 4th edn.American Psychiatric Press: Washington DC.Google Scholar
Bech, P, Gudex, C, Johansen, KS (1996). The WHO (ten) well-being index: validation in diabetes. Psychotherapy and Psychosomatics 65, 183–190.CrossRefGoogle ScholarPubMed
Beck, AT, Epstein, N, Brown, G, Steer, RA (1988). An inventory for measuring clinical anxiety: psychometric properties. Journal of Consulting and Clinical Psychology 56, 893–897.CrossRefGoogle ScholarPubMed
Bluhm, RL, Williamson, PC, Osuch, EA, Frewen, PA, Stevens, TK, Boksman, K, Neufeld, RW, Théberge, J, Lanius, RA (2009). Alterations in default network connectivity in posttraumatic stress disorder related to early-life trauma. Journal of Psychiatry and Neuroscience 34, 187–194.Google ScholarPubMed
Bonne, O, Gilboa, A, Louzoun, Y, Brandes, D, Yona, I, Lester, H, Barkai, G, Freedman, N, Chisin, R, Shalev, AY (2003). Resting regional cerebral perfusion in recent posttraumatic stress disorder. Biological Psychiatry 54, 1077–1086.CrossRefGoogle ScholarPubMed
Bremner, JD, Narayan, M, Staib, LH, Southwick, SM, McGlashan, T, Charney, DS (1999 a). Neural correlates of memories of childhood sexual abuse in women with and without posttraumatic stress disorder. American Journal of Psychiatry 156, 1787–1795.CrossRefGoogle ScholarPubMed
Bremner, JD, Staib, LH, Kaloupek, D, Southwick, SM, Soufer, R, Charney, DS (1999 b). Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: a positron emission tomography study. Biological Psychiatry 45, 806–816.CrossRefGoogle ScholarPubMed
Bremner, JD, Vythilingam, M, Vermetten, E, Southwick, SM, McGlashan, T, Staib, LH, Soufer, R, Charney, DS (2003). Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biological Psychiatry 53, 879–889.CrossRefGoogle ScholarPubMed
Bryant, RA, Harvey, AG (1996). Visual imagery in posttraumatic stress disorder. Journal of Traumatic Stress 9, 613–619.CrossRefGoogle ScholarPubMed
Buckner, RL, Andrews-Hanna, JR, Schacter, DL (2008). The brain's default network: anatomy, function, and relevance to disease. Annals of the New York Academy of Sciences 1124, 1–38.CrossRefGoogle ScholarPubMed
Cavada, C, Goldman-Rakic, PS (1989). Posterior parietal cortex in rhesus monkey: I. parcellation of areas based on distinctive limbic and sensory corticocortical connections. The Journal of Comparative Neurology 287, 393–421.CrossRefGoogle ScholarPubMed
Cavanna, AE (2007). The precuneus and consciousness. CNS Spectrums 12, 545–552.CrossRefGoogle ScholarPubMed
Chen, S, Xia, W, Li, L, Liu, J, He, Z, Zhang, Z, Yan, L, Zhang, J, Hu, D (2006). Gray matter density reduction in the insula in fire survivors with posttraumatic stress disorder: a voxel-based morphometric study. Psychiatry Research: Neuroimaging 146, 65–72.CrossRefGoogle ScholarPubMed
Chételat, G, Desgranges, B, de la Sayette, V, Viader, F, Berkouk, K, Landeau, B, Lalevée, C, Le Doze, F, Dupuy, B, Hannequin, D, Baron, JC, Eustache, F (2003). Dissociating atrophy and hypometabolism impact on episodic memory in Mild Cognitive Impairment. Brain 126, 1955–1967.CrossRefGoogle ScholarPubMed
Chua, P, Krams, M, Toni, I, Passingham, R, Dolan, R (1999). A functional anatomy of anticipatory anxiety. Neuroimage 9(6 Pt 1), 563–571.CrossRefGoogle ScholarPubMed
Cook, RD (1977). Detection of influential observation in linear regression. Technometrics 19, 15–18.Google Scholar
Corbo, V, Clément, MH, Armony, JL, Pruessner, JC, Brunet, A (2005). Size versus shape differences: Contrasting voxel-based and volumetric analyses of the anterior cingulate cortex in individuals with acute posttraumatic stress disorder. Biological Psychiatry 58, 119–124.CrossRefGoogle ScholarPubMed
Craig, AD (2010). The sentient self. Brain Structure and Function 214, 563–577.CrossRefGoogle ScholarPubMed
Desgranges, B, Baron, JC, Eustache, F (1998). The functional neuroanatomy of episodic memory: the role of the frontal lobes, the hippocampal formation, and other areas. Neuroimage 8, 198–213.CrossRefGoogle ScholarPubMed
Diener, E, Eunkook, MS, Lucas, RE, Smith, HL (1999). Subjective well-being: three decades of progress. Psychological Bulletin 125, 276–302.CrossRefGoogle Scholar
Diener, E, Suh, E, Oishi, S (1997). Recent findings on subjective well-being. Indian Journal of Clinical Psychology 24, 25–41.Google Scholar
Etkin, A, Wager, TD (2007). Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry 164, 1476–1488.CrossRefGoogle ScholarPubMed
Felmingham, K, Kemp, AH, Williams, L, Falconer, E, Olivieri, G, Peduto, A, Bryant, R (2008). Dissociative responses to conscious and non-conscious fear impact underlying brain function in post-traumatic stress disorder. Psychological Medicine 38, 1771–1780.CrossRefGoogle ScholarPubMed
First, MB, Spitzer, R, Gibbon, M, Williams, J (1997). User's Guide for the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I): Clinician Version. Psychiatric Institute, Biometrics Research Department: New York.Google Scholar
Fischer, H, Wik, G, Fredrikson, M (1996). Functional neuroanatomy of robbery re-experience: Affective memories studied with PET. Neuroreport 7, 2081–2086.CrossRefGoogle ScholarPubMed
Fletcher, PC, Shallice, T, Frith, CD, Frackowiak, RS, Dolan, RJ (1996). Brain activity during memory retrieval. The influence of imagery and semantic cueing. Brain 119, 1587–1596.CrossRefGoogle ScholarPubMed
Fonzo, GA, Simmons, AN, Thorp, SR, Norman, SB, Paulus, MP, Stein, MB (2010). Exaggerated and disconnected insular-amygdalar Blood Oxygenation Level-Dependent response to threat-related emotional faces in women with intimate-partner violence Posttraumatic Stress Disorder. Biological Psychiatry 68, 433–441.CrossRefGoogle ScholarPubMed
Fox, MD, Snyder, AZ, Vincent, JL, Corbetta, M, van Essen, DC, Raichle, ME (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proceedings of the National Academy of Sciences of the United States of America 102, 9673–9678.CrossRefGoogle ScholarPubMed
Francati, V, Vermetten, E, Bremner, JD (2007). Functional neuroimaging studies in posttraumatic stress disorder: review of current methods and findings. Depression and Anxiety 24, 212–218.CrossRefGoogle ScholarPubMed
Frewen, PA, Lanius, RA, Dozois, DJ, Neufeld, RW, Pain, C, Hopper, JW, Densmore, M, Stevens, TK (2008). Clinical and neural correlates of alexithymia in posttraumatic stress disorder. Journal of Abnormal Psychology 117, 171–181.CrossRefGoogle ScholarPubMed
Geuze, E, Westenberg, HG, Jochims, A, de Kloet, CS, Bohus, M, Vermetten, E, Schmahl, C (2007). Altered pain processing in veterans with Posttraumatic Stress Disorder. Archives of General Psychiatry 64, 76–85.CrossRefGoogle ScholarPubMed
Greicius, MD, Krasnow, B, Reiss, AL, Menon, V (2003). Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences 100, 253–258.CrossRefGoogle Scholar
Hamilton, M (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry 23, 56–62.CrossRefGoogle ScholarPubMed
Hamilton, M (1969). Diagnosis and rating of anxiety. British Journal of Psychiatry 3, 76–79.Google Scholar
Högberg, G, Pagani, M, Sundin, Ö, Soares, J, Åberg-Wistedt, A, Tärnell, B, Hällström, T (2008). Treatment of post-traumatic stress disorder with eye movement desensitization and reprocessing: outcome is stable in 35-month follow-up. Psychiatry Research 159, 101–108.CrossRefGoogle ScholarPubMed
Hopper, JW, Frewen, PA, van der Kolk, BA, Lanius, RA (2007). Neural correlates of re-experiencing, avoidance, and dissociation in PTSD: symptom dimensions and emotion dysregulation in responses to script-driven trauma imagery. Journal of Traumatic Stress 20, 713–725.CrossRefGoogle Scholar
Horowitz, MJ, Wilmer, N, Alvarez, W (1979). Impact of event scale: a measure of subjective stress. Psychosomatic Medicine 41, 209–218.CrossRefGoogle Scholar
Husain, M, Nachev, P (2006). Space and the parietal cortex. Trends in Cognitive Sciences 11, 30–36.CrossRefGoogle ScholarPubMed
Joseph, S (2000). Psychometric evaluation of Horowitz's Impact of Event Scale: a review. Journal of Traumatic Stress 13, 101–113.CrossRefGoogle ScholarPubMed
Joseph, S, Dalgleish, T, Thrasher, S, Yule, W, Williams, R, Hodgkinson, P (1996). Chronic emotional processing in survivors of the Herald of Free Enterprise disaster: the relationship of intrusion and avoidance at 3 years to distress at 5 years. Behaviour Research and Therapy 34, 357–360.CrossRefGoogle ScholarPubMed
Karl, A, Schaefer, M, Malta, LS, Dörfel, D, Rohleder, N, Werner, A (2006). A meta-analysis of structural brain abnormalities in PTSD. Neuroscience and Biobehavioral Reviews 30, 1004–1031.CrossRefGoogle ScholarPubMed
Kim, SJ, Lyoo, IK, Lee, YS, Kim, J, Sim, ME, Bae, SJ, Kim, HJ, Lee, JY, Jeong, DU (2007). Decreased cerebral blood flow of thalamus in PTSD patients as a strategy to reduce re-experience symptoms. Acta Psychiatrica Scandinavica 116, 145–153.CrossRefGoogle ScholarPubMed
King, AP, Abelson, JL, Britton, JC, Phan, KL, Taylor, SF, Liberzon, I (2009). Medial prefrontal cortex and right insula activity predict plasma ACTH response to trauma recall. Neuroimage 47, 872–880.CrossRefGoogle ScholarPubMed
Kobayashi, Y, Amaral, DG (2003). Macaque monkey retrosplenial cortex: II. Cortical afferents. The Journal of Comparative Neurology 466, 48–79.CrossRefGoogle ScholarPubMed
Kobayashi, Y, Amaral, DG (2007). Macaque monkey retrosplenial cortex: III. Cortical efferents. The Journal of Comparative Neurology 502, 810–833.CrossRefGoogle ScholarPubMed
Lang, PJ, Levin, DN, Miller, GA, Kozak, MJ (1983). Fear behaviour, fear imagery, and the psychophysiology of emotion: the problem of affective response integration. Journal of Abnormal Psychology 92, 276–306.CrossRefGoogle ScholarPubMed
Lange, C, Kracht, L, Herholz, K, Sachsse, U, Irle, E (2005). Reduced glucose metabolism in temporo-parietal cortices of women with borderline personality disorder. Psychiatry Research 139, 115–126.CrossRefGoogle ScholarPubMed
Lanius, RA, Bluhm, RL, Coupland, NJ, Hegadoren, KM, Rowe, B, Théberge, J, Neufeld, RW, Williamson, PC, Brimson, M (2010). Default mode network connectivity as a predictor of post-traumatic stress disorder symptom severity in acutely traumatized subjects. Acta Psychiatrica Scandinavica 121, 33–40.CrossRefGoogle ScholarPubMed
Lanius, RA, Williamson, PC, Bluhm, RL, Densmore, M, Boksman, K, Neufeld, RW, Gati, JS, Menon, RS (2005). Functional connectivity of dissociative responses in posttraumatic stress disorder: a functional magnetic resonance imaging investigation. Biological Psychiatry 57, 873–884.CrossRefGoogle ScholarPubMed
Lanius, RA, Williamson, PC, Densmore, M, Boksman, K, Neufeld, RW, Gati, JS, Menon, RS (2004). The nature of traumatic memories: a 4-T FMRI functional connectivity analysis. American Journal of Psychiatry 161, 36–44.CrossRefGoogle ScholarPubMed
Leichnetz, GR (2001). Connections of the medial posterior parietal cortex (area 7m) in the monkey. Anatomical Record 263, 215–236.CrossRefGoogle ScholarPubMed
Liberzon, I, Britton, JC, Phan, KL (2003). Neural correlates of traumatic recall in posttraumatic stress disorder. Stress 6, 151–156.CrossRefGoogle ScholarPubMed
Liberzon, I, Sripada, CS (2008). The functional neuroanatomy of PTSD: a critical review. Progress in Brain Research 167, 151–169.CrossRefGoogle ScholarPubMed
Lindauer, RJ, Booij, J, Habraken, JB, van Meijel, EP, Uylings, HB, Olff, M, Carlier, IV, den Heeten, GJ, van Eck-Smit, BL, Gersons, BP (2008). Effects of psychotherapy on regional cerebral blood flow during trauma imagery in patients with post-traumatic stress disorder: a randomized clinical trial. Psychological Medicine 38, 543–554.CrossRefGoogle ScholarPubMed
Lucey, JV, Costa, DC, Adshead, G, Deahl, M, Busatto, G, Gacinovic, S, Travis, M, Pilowsky, L, Ell, PJ, Marks, IM, Kerwin, RW (1997). Brain blood flow in anxiety disorders. OCD, panic disorder with agoraphobia, and post-traumatic stress disorder on 99mTcHMPAO single photon emission tomography (SPET). British Journal of Psychiatry 171, 346–350.CrossRefGoogle ScholarPubMed
McFarlane, AC (1992). Avoidance and intrusion in posttraumatic stress disorder. Journal of Nervous and Mental Disease 180, 439–445.CrossRefGoogle ScholarPubMed
Milner, AD, Goodale, MA (1995). The Visual Brain in Action. University Press: Oxford.Google Scholar
Molina, ME, Isoardi, R, Prado, MN, Bentolila, S (2010). Basal cerebral glucose distribution in long-term post-traumatic stress disorder. World Journal of Biological Psychiatry 11, 493–501.CrossRefGoogle ScholarPubMed
Morey, RA, Dolcos, F, Petty, CM, Cooper, DA, Hayes, JP, LaBar, KS, McCarthy, G (2009). The role of trauma-related distractors on neural systems for working memory and emotion processing in posttraumatic stress disorder. Journal of Psychiatric Research 43, 809–817.CrossRefGoogle ScholarPubMed
Nagai, M, Kishi, K, Kato, S (2007). Insular cortex and neuropsychiatric disorders: a review of recent literature. European Psychiatry 22, 387–394.CrossRefGoogle ScholarPubMed
Nardo, D, Högberg, G, Looi, JC, Larsson, S, Hällström, T, Pagani, M (2010). Gray matter density in limbic and paralimbic cortices is associated with trauma load and EMDR outcome in PTSD patients. Journal of Psychiatric Research 44, 477–485.CrossRefGoogle ScholarPubMed
Nielsen, FÅ, Balslev, D, Hansenb, LK (2005). Mining the posterior cingulate: segregation between memory and pain components. Neuroimage 27, 520–532.CrossRefGoogle ScholarPubMed
Nutt, DJ, Malizia, AL (2004). Structural and functional brain changes in posttraumatic stress disorder. Journal of Clinical Psychiatry 65 (Suppl. 1), 11–17.Google ScholarPubMed
Ormel, J, Vonkorff, M, Oldehinkel, AJ, Simon, G, Tiemens, BG, Üstün, TB (1999). Onset of disability in depressed and non-depressed primary care patients. Psychological Medicine 29, 847–853.CrossRefGoogle ScholarPubMed
Osuch, EA, Benson, B, Geraci, M, Podell, D, Herscovitch, P, McCann, UD, Post, RM (2001). Regional cerebral blood flow correlated with flashback intensity in patients with posttraumatic stress disorder. Biological Psychiatry 50, 246–253.CrossRefGoogle ScholarPubMed
Osuch, EA, Ketter, TA, Kimbrell, TA, George, MS, Benson, BE, Willis, MW, Herscovitch, P, Post, RM (2000). Regional cerebral metabolism associated with anxiety symptoms in affective disorder patients. Biological Psychiatry 48, 1020–1023.CrossRefGoogle ScholarPubMed
Pagani, M, Högberg, G, Salmaso, D, Nardo, D, Sundin, O, Jonsson, C, Soares, J, Aberg-Wistedt, A, Jacobsson, H, Larsson, SA, Hällström, T (2007). Effects of EMDR psychotherapy on 99mTc-HMPAO distribution in occupation-related post-traumatic stress disorder. Nuclear Medicine Communications 28, 757–765.CrossRefGoogle ScholarPubMed
Pagani, M, Högberg, G, Salmaso, D, Tärnell, B, Sanchez-Crespo, A, Soares, J, Åberg-Wistedt, A, Jacobsson, H, Hällström, T, Larsson, SA, Sundin, Ö (2005). Regional cerebral blood flow during auditory recall in 47 subjects exposed to assaultive and non-assaultive trauma and developing or not posttraumatic stress disorder. European Archives of Psychiatry and Clinical Neuroscience 255, 359–365.CrossRefGoogle ScholarPubMed
Paulus, MP, Stein, MB (2010). Interoception in anxiety and depression. Brain Structure and Function 214, 451–463.CrossRefGoogle ScholarPubMed
Peres, JF, Newberg, AB, Mercante, JP, Simão, M, Albuquerque, VE, Peres, MJ, Nasello, AG (2007). Cerebral blood flow changes during retrieval of traumatic memories before and after psychotherapy: a SPECT study. Psychological Medicine 37, 1481–1491.CrossRefGoogle ScholarPubMed
Phan, KL, Wager, TD, Taylor, SF, Liberzon, I (2002). Functional neuroanatomy of emotion: a meta-analysis of emotion activation studies in PET and fMRI. Neuroimage 16, 331–348.CrossRefGoogle ScholarPubMed
Sachinvala, N, Kling, A, Suffin, S, Lake, R, Cohen, M (2000). Increased regional cerebral perfusion by 99mTc hexamethyl propylene amine oxime single photon emission computed tomography in post-traumatic stress disorder. Military Medicine 165, 473–479.CrossRefGoogle ScholarPubMed
Shaw, ME, Moores, KA, Clark, RC, McFarlane, AC, Strother, SC, Bryant, RA, Brown, GC, Taylor, JD (2009). Functional connectivity reveals inefficient working memory systems in post-traumatic stress disorder. Psychiatry Research 172, 235–241.CrossRefGoogle ScholarPubMed
Shaw, ME, Strother, SC, McFarlane, AC, Morris, P, Anderson, J, Clark, CR, Egan, GF (2002). Abnormal functional connectivity in posttraumatic stress disorder. Neuroimage 15, 661–674.CrossRefGoogle ScholarPubMed
Simmons, A, Paulus, MP, Thorp, SR, Matthews, SC, Norman, SB, Stein, MB (2008). Functional activation and neural networks in women with posttraumatic stress disorder related to intimate partner violence. Biological Psychiatry 64, 681–690.CrossRefGoogle ScholarPubMed
Stein, MB, Simmons, AN, Feinstein, JS, Paulus, MP (2007). Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. American Journal of Psychiatry 164, 318–327.CrossRefGoogle ScholarPubMed
Strigo, IA, Simmons, AN, Matthews, SC, Grimes, EM, Allard, CB, Reinhardt, LE, Paulus, MP, Stein, MB (2010). Neural correlates of altered pain response in women with Posttraumatic Stress Disorder from intimate partner violence. Biological Psychiatry 68, 442–450.CrossRefGoogle ScholarPubMed
Taylor, JG (2001). The central role of the parietal lobes in consciousness. Consciousness and Cognition 10, 379–417.CrossRefGoogle ScholarPubMed
Torrey, EF (2007). Schizophrenia and the inferior parietal lobule. Schizophrenia Research 97, 215–225.CrossRefGoogle ScholarPubMed
van der Hart, O, Bolt, H, van der Kolk, BA (2005). Memory fragmentation in dissociative identity disorder. Journal of Trauma Dissociation 6, 55–70.CrossRefGoogle ScholarPubMed
van der Kolk, BA (1994). The body keeps the score: memory and the evolving psychobiology of posttraumatic stress. Harvard Review of Psychiatry 1, 253–265.CrossRefGoogle ScholarPubMed
van der Kolk, BA, Burbridge, JA, Suzuki, J (1997). The psychobiology of traumatic memory. Clinical implications of neuroimaging studies. Annals of the New York Academy of Sciences 821, 99–113.CrossRefGoogle ScholarPubMed
Vogt, BA, Laureys, S (2005). Posterior cingulate, precuneal and retrosplenial cortices: cytology and components of the neural network correlates of consciousness. Progress in Brain Research 150, 205–217.CrossRefGoogle ScholarPubMed
Whalley, MG, Rugg, MD, Smith, AP, Dolan, RJ, Brewina, CR (2009). Incidental retrieval of emotional contexts in post-traumatic stress disorder and depression: an fMRI study. Brain and Cognition 69, 98–107.CrossRefGoogle ScholarPubMed
Wiens, S (2005). Interoception in emotional experience. Current Opinion in Neurology 18, 442–447.CrossRefGoogle ScholarPubMed