Elsevier

Neurobiology of Stress

Volume 1, January 2015, Pages 66-79
Neurobiology of Stress

Peripheral and central mechanisms of stress resilience

https://doi.org/10.1016/j.ynstr.2014.09.004Get rights and content
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open access

Abstract

Viable new treatments for depression and anxiety have been slow to emerge, likely owing to the complex and incompletely understood etiology of these disorders. A budding area of research with great therapeutic promise involves the study of resilience, the adaptive maintenance of normal physiology and behavior despite exposure to marked psychological stress. This phenomenon, documented in both humans and animal models, involves coordinated biological mechanisms in numerous bodily systems, both peripheral and central. In this review, we provide an overview of resilience mechanisms throughout the body, discussing current research in animal models investigating the roles of the neuroendocrine, immune, and central nervous systems in behavioral resilience to stress.

Keywords

Resilience
Stress
Depression
Anxiety
Neuroimmune
Plasticity

Abbreviations

CUS
chronic unpredictable stress
SCUS
subchronic unpredictable stress
CSDS
chronic social defeat stress
LH
learned helplessness
LG
licking and grooming
OVX
ovariectomy
SDR
social disruption stress

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