Longitudinal studies of cognition and functional outcome in schizophrenia: implications for MATRICS
Section snippets
Longitudinal studies of cognition and community outcome in schizophrenia
For this review of the literature, we were primarily interested in longitudinal studies that examined the cognitive predictors of some aspect of community functioning. With this fairly specific goal in mind, we did not consider the cognitive predictors and correlates of rehabilitation success or performance on simulated tasks of interpersonal communication, as we have done in our previous reviews (Green, 1996, Green et al., 2000). We specifically selected studies that were not part of the
Mapping changes in cognitive performance measures onto changes in functional outcome
At the MATRICS meeting in April 2003 (see summary in Green et al., 2004), a key discussion point was whether changes in cognitive performance alone should be sufficient for a drug to receive approval from the U.S. Food and Drug Administration (FDA). On the one hand, improvement on a cognitive performance measure appears to be the most reliable and sensitive way to establish that a drug improves cognition. On the other hand, changes on cognitive performance measures alone may not be sufficient
Summary
In summary, we have documented rather consistent relationships between baseline assessments in schizophrenia and community functioning at a minimum of 6 months later. The cross-sectional relationships between cognition and functional outcome have been well established in previous reviews (Green, 1996, Green et al., 2000), and the demonstration of these longitudinal relationships in the current review indicates that cognitive performance at one point in time predicts community functioning at a
Acknowledgments
An earlier version of this paper was presented at the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Conference #1: Identifying Cognitive Targets and Establishing Criteria for Test Selection, Bethesda, MD. Support for this conference came from NIMH Contract MH22006 (S.R. Marder, P.I., M.F. Green, Co-P.I.)
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