Quality of life after radiotherapyQuality of life as predictor of survival: A prospective study on patients treated with combined surgery and radiotherapy for advanced oral and oropharyngeal cancer
Section snippets
Patients
Patients diagnosed with advanced squamous cell carcinomas of the oral cavity or the oropharynx were recruited for this prospective study between January 1998 and December 2001. Patients were planned to be treated by composite resections with microvascular soft tissue transfer (i.e. radial forearm free flap (RFFF)) for the reconstruction of their surgical defects, supplemented by radiotherapy on indication. Exclusion criteria were age greater than 75 years, serious cognitive impairment and lack
Sample description
Patient characteristics are shown in Table 1. The patients’ age ranged from 23 to 74 years (mean = 58 years). Forty-one percent of the sample was female. Fifty-four patients (67%) had a partner. Oral cavity tumors represented 47% (n = 38) of the cases, and oropharynx tumors 53% (n = 42). Tonsil, mobile tongue, floor-of-mouth, and base-of-tongue were the most common subsites (30%, 23%, 20%, and 14%, respectively). One patient was treated for a recurrent tumor after transoral excision (1 year earlier) and
Discussion
The main objective of the present study was to assess prospectively whether deterioration of HRQOL after treatment contributes in predicting survival besides clinical and sociodemographic aspects, in a cohort of 80 patients with advanced oral or oropharyngeal cancer all treated by reconstructive surgery and postoperative radiotherapy.
Regarding clinical predictors, tumor stage and site were predictive of survival in univariate analyses but not in the multivariate model, probably because of the
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