Poor sleep as a pathophysiological pathway underlying the association between stressful experiences and the diurnal cortisol profile among children and adolescents
Section snippets
Participants
Youth aged 8–18 were recruited as part of the Healthy Heart Project at Concordia University, Montreal, Quebec. Participants were recruited using bookmarks distributed in primary and secondary schools approved by the English Montreal School Board and flyers posted in the local neighbourhood. Youth with serious psychopathology (e.g., psychosis, severe depression) or medication use known to interfere with cardiovascular or endocrine functioning were not eligible to participate. Participants (N =
Descriptive statistics
On average, youth endorsed one in five stressors on the SLES (13.7 out of 76 events; 19.79%), with an average total stress intensity rating of 24.31 for the endorsed stressors. Consistent with previous adult studies, youth reported moderate levels of perceived stress (Cohen et al., 1983). Mean sleep disturbance scores were consistent with previous research (Owens et al., 2000). Youth reported good sleep quality and moderate daytime sleepiness. Youth reported 9.12 h of sleep during school nights,
Discussion
There is emerging evidence to support the contribution of poor sleep as a pathophysiological pathway underlying the adverse effect of stressful experiences on the diurnal cortisol profile. Previous cross-sectional and experimental findings demonstrate the adverse effects of stressful experiences on sleep, which subsequently disrupts the diurnal cortisol profile. Accordingly, it was hypothesized that the association between stressful experiences and diurnal cortisol would be mediated by sleep.
Conclusions
Taken together, the present study suggests that poor sleep is one potential pathophysiological pathway underlying the association between stressful experiences and diurnal cortisol in youth. Further, the association between stressful experiences and the diurnal cortisol profile in youth were linked to the quality, not the quantity of sleep. These findings provide empirical support for a plausible neuroendocrinological relation between stress experiences, sleep, and diurnal cortisol among
Role of the funding source
This work was made possible through funding support from the Canadian Institutes of Health Research Operating Grants (J.J. McGrath MOP89886 and OCO79897), New Investigator Award (J.J. McGrath MSH95353), and Fonds de recherche Québec santé bourse de formation maîtrise (J. Ly).
Conflict of interest statement
None declared.
Acknowledgments
We thank the participants and their families of the Healthy Heart Project and the research assistants and project coordinators of the Pediatric Public Health Psychology Laboratory. Special thanks to Natasha Hunt, Sabrina Giovanniello, and Neressa Noel for their continued dedication.
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