Original ArticleGestational Age, Perinatal Characteristics, and Autism Spectrum Disorder: A Birth Cohort Study
Section snippets
Methods
This is a population-based retrospective cohort study using the 1994-2000 Olmsted County Birth Cohort. Olmsted County is located in southeast Minnesota and is home to the Mayo Clinic. The cohort was identified using birth certificate data obtained from the Minnesota Department of Health and using the resources of the Rochester Epidemiology Project (REP). The REP is a medical records-linkage system that includes outpatient and inpatient records from providers in the community, including Mayo
Results
This study evaluated data from 8115 children in the 1994-2000 Olmsted County Birth Cohort who resided in Olmsted County at age 3 years (Figure 1). There were 7876 children included in the analysis after we applied the inclusion and exclusion criteria. The incidence of preterm birth (<37 weeks' gestation) was 8.6% in this cohort, which was lower than the national average (11%) for the period.30,31 Moderate-to-late preterm birth (32-36 weeks' gestation) accounted for the majority of premature
Discussion
Using an Olmsted County birth cohort of children born 1994-2000, we found multiple perinatal risk factors for ASD-R. Unadjusted analyses revealed male sex, maternal marital status, maternal education level, tobacco use during pregnancy, and inappropriately low weight gain during pregnancy to be associated with ASD-R. In the multivariable model for the full cohort, male sex, maternal age, maternal marital status, and tobacco use during pregnancy were significantly associated with ASD-R. In this
Data Statement
Data sharing statement available at www.jpeds.com.
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This study was made possible using the resources of the Rochester Epidemiology Project with support from the National Institute on Aging (R01AG034676) and from the National Institute of Mental Health (MH093522) of the National Institutes of Health (NIH). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The authors declare no conflicts of interest.