Elsevier

The Journal of Pain

Volume 17, Issue 1, January 2016, Pages 119-125
The Journal of Pain

Original Report
Total Western Diet Alters Mechanical and Thermal Sensitivity and Prolongs Hypersensitivity Following Complete Freund's Adjuvant in Mice

https://doi.org/10.1016/j.jpain.2015.10.006Get rights and content
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Highlights

  • The Total Western Diet (TWD) reduced acute sensitivity to mechanical and thermal stimuli.

  • Exposure to TWD increased fat mass and leptin and inflammatory cytokine levels.

  • TWD prolonged return to baseline sensitivity after complete Freund's adjuvant.

  • TWD is proinflammatory and may lead to susceptibility to chronic pain.

Abstract

Obesity and chronic pain are often comorbid and their rates are increasing. It is unknown whether increased pain is caused by greater weight or poor diet quality or both. Therefore, we utilized a Total Western Diet (TWD) to investigate the functional and physiologic consequences of nutritionally poor diet in mice. For 13 weeks on the commercially available TWD, based on the National Health and Nutrition Examination Survey, thresholds of TWD-fed mice significantly increased in both thermal and mechanical tests. Quantitative magnetic resonance imaging revealed a significant increase in fat mass with a concomitant decrease in lean mass in the TWD-fed mice. In addition, there were significant increases in levels of serum leptin and inflammatory cytokines. After chronic pain induction using complete Freund's adjuvant, hypersensitivity was more pronounced and significantly prolonged in the TWD-fed mice. Therefore, prolonged exposure to poor diet quality resulted in altered acute nociceptive sensitivity, systemic inflammation, and persistent pain after inflammatory pain induction.

Perspective

These results highlight the negative effects of poor diet quality with respect to recovery from hypersensitivity and susceptibility to chronic pain. A complete understanding of the impact of diet can aid in treatment and recovery dynamics in human clinical patients.

Key words

Diet
pain
mice
inflammation
hypersensitivity

Cited by (0)

This work was supported by a University of Alabama at Birmingham College of Arts and Science Interdisciplinary Team Innovation Award received by B.A.G. and R.E.S.

The authors have no conflict of interest involving this work.