Dentoalveolar surgery
Effect of Platelet-Rich Fibrin on Frequency of Alveolar Osteitis Following Mandibular Third Molar Surgery: A Double-Blinded Randomized Clinical Trial

https://doi.org/10.1016/j.joms.2014.03.029Get rights and content

Purpose

To evaluate the effectiveness of platelet-rich fibrin (PRF) in preventing the development of alveolar osteitis (AO).

Materials and Methods

In a double-blinded study, patients with bilateral impacted mandibular third molars underwent surgical extractions, with one socket receiving PRF and the other one serving as a control. The surgeon and patient were unaware of the study or control side. The predictor variable was the PRF application and was categorized as PRF and non-PRF. The outcome variable was the development of AO during the first postoperative week. Other study variables included age, gender, smoking status, irrigation volume, extraction difficulty, surgeon experience, and number of anesthetic cartridges. Data were analyzed using χ2 and t tests, with the significance level set at a P value less than .05.

Results

Seventy-eight patients (mean age, 25 yr) underwent 156 impacted third molar surgeries. The overall frequency of AO was 14.74% for all surgeries. The frequency of AO in the PRF group was significantly lower than in the non-PRF group (odds ratio = 0.44; P < .05).

Conclusion

Based on the results of the present study, PRF application may decrease the risk of AO development after mandibular third molar surgery.

Section snippets

Materials and Methods

The present study was conducted at the Mashhad Dental Clinic of Oral and Maxillofacial Surgery (Mashhad, Iran). The ethical board of the Mashhad University of Medical Sciences approved the study protocol and all patients provided a signed, detailed informed consent.

Results

Eighty-five patients met the inclusion criteria and entered the study; however, 6 patients received more than 2 anesthetic cartridges and 1 female patient had used oral contraceptives during the first postoperative week (as emergency birth control). Therefore, 78 patients (33 male and 45 female; mean age, 25.09 ± 4.25 yr) completed the study. Because each patient served as his or her own control, no significant differences were observed in the demographic variables, including sample size,

Discussion

The aim of the present study was to investigate the effect of PRF application on the frequency of AO after the surgical removal of mandibular third molars. The null hypothesis was that the frequency of AO with and without application of PRF after surgery would be equal. The authors measured and compared the frequency of AO after the surgical removal of impacted mandibular third molars in PRF and non-PRF sockets. The hypothesis was rejected because the frequency of AO was significantly lower in

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