Case reportRational Management of Macroglossia Due to Acquired Systemic Amyloidosis: Does Surgery Play a Role?
Section snippets
Report of a Case
A 57-year-old woman was referred to the Department of Oral and Maxillofacial Surgery, School of Medicine, University of Valencia (Valencia, Spain), complaining of a 6-month history of a progressively enlarged tongue, sialorrhea, and dysphagia to solids. Practically concurring with the onset of these symptoms, she had begun to notice an increasing submental swelling. Her medical history was significant for penicillin allergy, hypothyroidism under hormone replacement therapy, and endometrioid
Discussion
Acquired systemic light-chain amyloidosis, the most frequent type of clinical amyloid disease in the developed world, has previously been referred to as primary amyloidosis. In our opinion, this term is misleading and should definitely be abandoned, because AL amyloidosis is typically secondary to an underlying plasma cell dyscrasia such as multiple myeloma. In fact, some investigators regard macroglossia as a paraneoplastic manifestation of the causal disorder and claim that, if a patient with
References (24)
- et al.
Plasma cell dyscrasias and amyloidosis
Otolaryngol Clin North Am
(2003) - et al.
Surgical management of macroglossia due to primary amyloidosis
Int J Oral Maxillofac Surg
(1999) - et al.
Incidence and natural history of primary systemic amyloidosis in Olmsted County, Minnesota, 1950 through 1989
Blood
(1992) - et al.
Amyloidosis of the tongue as a paraneoplastic marker of plasma cell dyscrasia
Oral Surg Oral Med Oral Pathol Oral Radiol Endod
(2002) - et al.
Effects of surgical reduction of the tongue
Br J Oral Maxillofac Surg
(1999) - et al.
Diagnosis of macroglossia and indications for reduction glossectomy
Am J Orthod Dentofac Orthop
(1996) - et al.
Amyloid deposition in the oral cavity: A retrospective study and review of the literature
Oral Surg Oral Med Oral Pathol
(2003) - et al.
Macroglossia in myelomatosis
Br J Plast Surg
(1969) - et al.
A tongue resection in macroglossia due to primary amyloidosis
Br J Oral Maxillofac Surg
(1989) - et al.
Primary amyloidosis causing macroglossia and respiratory symptoms
Br J Oral Maxillofac Surg
(1985)