Basic and patient-oriented researchBisphosphonate-Related Osteonecrosis of the Jaws: A Single-Center Study of 101 Patients
Section snippets
Patients
The study included all patients with ONJ after treatment with BPs who were followed up at the Department of Oral and Maxillofacial Surgery, Sheba Medical Center (Tel Hashomer, Israel) between April 2003 and January 2008 and examined by 2 members of the department (N.Y. and T.S.L.). Criteria for inclusion in the study, in accordance with the American Association of Oral and Maxillofacial Surgeons' position paper on BP-related ONJ, were as follows: history of BP therapy, intraoral lesions (eg,
Patients
The study group included 66 women (mean age, 63 years; range, 40-85 years) and 35 men (mean age, 64 years; range, 54-88 years) diagnosed as having BP-associated ONJ.
Smoking Habits
Of the patients, 19 (19%) had a history of smoking either currently or in the recent past. The mean smoking consumption was 21 cigarettes per day (range, 7-35 cigarettes per day), and the mean duration of cigarette smoking was 29 years (range, 20-40 years).
BP Indication
Of the patients, 43 (43%) received IV BPs (pamidronate or zoledronic acid)
Discussion
During the past decade, BPs have been widely used for the treatment of bone metastases in malignancies, such as multiple myeloma and breast and prostate carcinoma,1, 2, 3, 4, 5, 6, 7 as well as for bone resorption diseases, such as osteopenia and osteoporosis.8
With improvement in treatment protocols for cancer patients, increasing numbers of patients will be able to receive BPs for many years. This, together with the increase in life expectancy, will probably lead to more patients being
Acknowledgments
The authors thank Ms Esther Eshkol for editorial assistance.
References (32)
- et al.
Bisphosphonate osteochemonecrosis (bis-phossy jaw): Is this phossy jaw of the 21st century?
J Oral Maxillofac Surg
(2005) - et al.
Osteonecrosis of the jaws associated with cancer chemotherapy
J Oral Maxillofac Surg
(2003) Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: A growing epidemic
J Oral Maxillofac Surg
(2003)- et al.
Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases
J Oral Maxillofac Surg
(2004) - et al.
Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws: Risk factors, recognition, prevention, and treatment
J Oral Maxillofac Surg
(2005) - et al.
Managing the care of patients with bisphosphonate-associated osteonecrosis: An American Academy of Oral Medicine position paper
J Am Dent Assoc
(2005) - et al.
Incidence of osteonecrosis of the jaw in patients with multiple myeloma and breast or prostate cancer on intravenous bisphosphonate therapy
J Oral Maxillofac Surg
(2007) - et al.
Nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in Australia
J Oral Maxillofac Surg
(2007) - et al.
“Bis-phossy jaws”—High and low risk factors for bisphosphonate-induced osteonecrosis of the jaw
J Craniomaxillofac Surg
(2008) Is avascular necrosis of the femoral head the result of inhibition of angiogenesis?
Med Hypotheses
(1997)
Oral bisphosphonate-induced osteonecrosis: Risk factors, prediction of risk using serum CTX testing, prevention, and treatment
J Oral Maxillofac Surg
Overview of bisphosphonates
Cancer
A dose-finding study of zoledronate in hypercalcemic cancer patients
J Bone Miner Res
Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases
Cancer Res
Bisphosphonate therapy in multiple myeloma: Past, present, future
Eur J Haematol
Intravenous pamidronate disodium treatment of bone metastases in patients with breast cancerA dose-seeking study
Cancer
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