Clinical ResearchAssociation of Endodontic Infection with Detection of an Initial Lesion to the Cardiovascular System
Section snippets
Study Design and Patient Population
The present study represents the first part of an observational cross-sectional trial conducted on young men observed at the Diagnostic Section of the Dental Clinic at the University of Cagliari during 2009. Subjects were divided into 2 groups, patients affected by AP and healthy controls. The study protocol was approved by the Institutional Ethics Committee (Azienda Ospedaliero-Universitaria, University of Cagliari). Written informed consent was obtained from all subjects.
Inclusion criteria
Results
Table 1 summarizes the basic dental features of the patients in the study group (AP).
In case of multirooted teeth, they were simply classified as having AP whether they exhibited 1 or more periapical lesions. There were no appreciable differences in anthropometric, clinical, and chemical parameters between AP subjects and controls. All patients in the study sample presented at least 1 lesion of endodontic origin. Neither electrocardiogram nor standard and TDI echocardiographic examinations
Discussion
In this study we found (1) a direct correlation between IL-2 and ADMA increases; (2) an inverse correlation between ADMA and EFR; (3) a significant increase in serum levels of IL-1, IL-2, IL-6, and ADMA in patients with AP; and (4) EFR values in the lower limit of normal in AP group, significantly reduced when compared with healthy controls. Both groups featured a lack of clinical and preclinical cardiac injury, as evidenced by normal parameters observed at conventional and TDI echocardiography.
Acknowledgments
The authors deny any conflicts of interest related to this study.
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Supported by the Fondazione Banco di Sardegna.