Quality of life and depression in Parkinson's disease
Section snippets
Depression in PD
Despite being the main determinant of poor Hr-QoL identified in cross-sectional studies and being recognized as an important problem by clinicians, until recently depression in PD has received relatively little attention in research studies. While it is recognized that depression can occur as a symptom of off-periods [35], [36] (and in these circumstances responds to antiparkinsonian medication), relatively little is known about depression independent of motor fluctuations.
Conclusion
Hr-QoL measurement allows a quantitative assessment of the subjective impact of PD on patients, incorporating a variety of physical, emotional and social factors. Using psychometrically developed, validated questionnaires, it has been demonstrated that depression is closely associated with impaired Hr-QoL in PD, over and above the objective impairment of motor and physical function and disability. Despite this importance of depression for Hr-QoL, relatively little is known about depression and
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