Responses to stress in patients with psychotic disorders compared to persons with varying levels of vulnerability to psychosis, persons with depression and healthy controls
Introduction
Since the late 1970s stress has been ascribed a central role in the pathogenesis of psychotic disorders (Nuechterlein and Dawson, 1984, Zubin and Spring, 1977). Vulnerability stress models differ in detail, but all assume that people have varying levels of vulnerability, and that the likelihood of psychotic symptoms is a function of the extent of vulnerability and stress that the individual encounters. The mechanisms that translate stress into psychotic symptoms are proposed to be decreased neuropsychological functioning resulting in a breakdown of information processing abilities in earlier models (Nuechterlein and Dawson, 1984, Zubin and Spring, 1977) and reasoning biases, perceptual anomalities and emotion-processing in more recent model variants for positive symptoms (Blackwood et al., 2001, Garety et al., 2001). Vulnerability stress models have a high face validity and are used as a basis of psycho-educational approaches that aim to help patients to monitor early symptoms by reducing stress in their every-day lives. Nevertheless, the evidence for the basic notion that stress triggers psychotic symptoms is not fully conclusive.
A common method to assess the impact of external stressors on psychopathology has been to retrospectively investigate life-events in periods followed by an increase in symptoms. Most of these studies found life-events to be precipitants of acute psychosis (Beards, Gayer-Anderson, Borges, Dewy, & Fisher, 2013). However, this retrospective methodology has been criticized (Philipps, Francey, Edwards, & McMurray, 2007), the major problem being that it does not answer the question whether stressful events cause psychosis. For instance, a patient might report that having been left by his wife triggered an episode of psychosis, while in fact being left was the consequence of prodromal symptoms.
More recent research has focused on the association of psychosis and everyday stressors, such as migration, isolation and discrimination (Cantor-Graae and Selten, 2005, Veling et al., 2007), urbanicity (Lederbogen et al., 2011, Weiser et al., 2007), or exposure to relatives with high-expressed emotion (Cutting, Aakre, & Docherty, 2006). Myin-Germeys and van Os (2007) took this approach several steps further: Using the Experience Sampling Method (ESM) to assess responses to hassles occurring in the participants' daily lives they found a clear association between minor stressors and the intensity of psychotic experiences in patients and their first-degree relatives. Although the cross-lagged analyses in the ESM studies indicate that stressors precede psychosis, the interpretation of the causal direction between stress and symptoms remains difficult. The report of stressors is not independent of the clinical status of the participants and therefore likely to be influenced by a number of disorder-related factors, including recall and attention biases (Philipps et al., 2007), illusory correlations or causal inferences which have been found in patients with psychotic disorders (Beer, Moritz, & Lincoln, 2012). Therefore, additional studies that control for the type and intensity of stressors are needed.
Beyond the question of causality, several relevant aspects related to the investigation of vulnerability-stress models need noting. One is that the stress response takes place on several levels, including psychophysiological responses. While some studies have assessed neuro-endocrine responses (Jansen et al., 2000, Thompson et al., 2007), autonomic responses have been neglected. Furthermore, few studies have differentiated between different types of stressors, such as social and non-social stressors. Also, it has been emphasized that more attempts need to be made to systematically compare the stress-responses of groups that differ in vulnerability, such as first-degree relatives and high- risk groups (Beards et al., 2013, Philipps et al., 2007). Finally, as stressors also tend to precede depression (Kessler, 1997, Stroud et al., 2008) more research is needed to assess whether psychosis is associated with a distinct stress response compared to depression.
To summarize, the existing body of research supports a connection between stress and psychosis but is less definite with regard to its causal directions. To provide a more conclusive answer to this question, the present study used an experimental design to investigate the impact of a noise and a social stressor on self-reported and psychophysiological stress parameters and paranoid symptoms in persons with varying levels of vulnerability to psychosis.
The study was preceded by two pilot studies demonstrating that a) paranoid beliefs increased in response to a noise stressor in healthy individuals and that this increase was moderated by baseline-vulnerability to psychosis (Lincoln, Peter, Schäfer, & Moritz, 2009) and b) that paranoid beliefs increased in response to a noise stressor in participants with psychotic disorders compared to healthy controls (Moritz et al., 2011). The present study extended on these findings and hypothesized (a) that the self-reported and psychophysiological (heart rate (HR), skin conductance level (SCL), salivary cortisol) response to induced stress will vary as a function of vulnerability (psychotic disorder, attenuated symptoms, first-degree-relatives, healthy) and (b) that psychotic symptoms will increase as a function of vulnerability and stress. Finally, in order to estimate the diagnosis-specificity, we compared the stress responses of the sample with psychotic disorders with those of a sample of patients with depression and contrasted the impact that stress exerts on paranoid symptoms with the impact it has on symptoms of depression.
Section snippets
Design
The study was conducted in Hamburg and Marburg (Germany) as a randomized repeated measures design. Participants with psychotic disorders (PSY) were compared to healthy persons with attenuated positive symptoms (AS), first-degree relatives of persons with psychotic disorders (REL), participants with depression (DEP) and healthy controls (HC) in regard to subjective stress ratings, psychophysiological parameters (HR, SCL and cortisol) and psychotic symptoms within a no stress, a noise stress and
Manipulation check
The repeated measures ANOVA of time and condition on self-reported stress revealed a time × condition interaction (F(10, 1470) = 11.4, p ≤ .01, η2partial = 0.07). Pairwise comparisons revealed significant differences between the neutral and the two stress conditions and between the noise and the social stress condition (all p ≤ .01) that are depicted in Fig. 2. Fig. 2 also indicates that the noise stressor had an earlier and more constant impact than the social stressor, the latter showing
Discussion
This study investigated the impact of stress on the self-reported, endocrine and autonomic stress response and symptoms in groups with varying degrees of vulnerability to psychosis. The manipulation of the stressors was successful in regard to participants' self-reported stress. However, there was no strong condition effect on the biological parameters: Although the social stressor showed an impact on heart-rate, the effect of the stress conditions was marginal in regard to SCL and absent in
Acknowledgments
Financial support for this study was provided by two grants from the German Research Foundation provided to the first (Li 1298/4-1) and last author (Mo 969/8-1). The authors would like to thank all participants for their participation, Ricarda Weil, Lisa Schilling, Jannes Gisch, Stephanie Blasé, Julia Graef and Mylén Bankowsky, for their help in conducting the study, Till Gröschner and Björn Schlier for their help with the data-management, and Annika Clamor and Klaus Wiedemann for their help
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