Patterns and predictors of comorbidity of DSM-IV anxiety disorders in a clinical sample of children and adolescents

https://doi.org/10.1016/j.janxdis.2013.01.010Get rights and content

Abstract

This study examined the comorbidity of anxiety disorders and its predictors in a large, clinically referred sample of children and adolescents. Participants were 608 youth aged 4–18 years presenting at a large anxiety clinic for assessment and treatment of anxiety or mood related problems. The diagnoses were determined using the Anxiety Disorder Interview Schedule, Child/Parent versions. Sixty three percent of the participants had an additional diagnosis of an anxiety or depressive disorder. Comorbidity patterns differed based on the principal diagnostic category. Older children and females with anxiety were more likely to have a comorbid anxiety disorder. The presence of a medical condition increased the odds of having a comorbid anxiety disorder as well. This is the largest clinical sample of children and adolescents in which comorbidity of emotional disorders has been examined. Understanding the common patterns of comorbidity has important implications for future classification and treatment planning of childhood anxiety disorders.

Highlights

► We examined comorbidity of anxiety disorders in children and adolescents. ► 63% of the sample has a comorbid anxiety or mood disorder. ► Age and sex predicted the presence of comorbidity.

Section snippets

Participants

Participants were 608 children and adolescents presenting for assessment and treatment for anxiety and related concerns at a large university-based outpatient clinic. The participants were consecutive referrals from the community, for specialized anxiety treatment. The mean age of participants was 12.03 (SD = 3.25), their age ranging from 4 to 18 years. 278 (45.7%) of the participants were males, and 330 (54.3%) were females. Eighty per cent of the participants were Caucasian. Income level was

Results

Table 1 presents the prevalence of all anxiety and depressive disorder diagnoses for patients with current DSM-IV principal diagnoses of generalized anxiety disorder (GAD), separation anxiety disorder (SAD), specific phobia (SPEC), social phobia (SOC), panic disorder with and without agoraphobia (PD/PDA), agoraphobia without history of panic disorder (AG), obsessive-compulsive disorder (OCD), anxiety disorder not otherwise specified (Anx NOS), post-traumatic stress disorder (PTSD), dysthymia

Discussion

The purpose of this study was to examine the comorbidity rates of anxiety disorders in the largest clinically referred sample of children and adolescents conducted to date, and to determine whether the presence of a comorbid disorder was associated with sex, age, medical condition, and maternal anxiety. The results of the study showed that 63% of the sample had a comorbid anxiety or mood disorder, which is similar to previous studies’ findings of comorbidity rates in children (e.g., Kendall et

References (50)

  • T.H. Ollendick et al.

    Comorbidity in youth with specific phobias: impact of comorbidity on treatment outcome and the impact of treatment on comorbid disorders

    Behaviour Research and Therapy

    (2010)
  • W.K. Silverman et al.

    Test–retest reliability of anxiety symptoms and diagnoses with the Anxiety Disorders Interview Schedule for DSM-IV: child and parent versions

    Journal of the American Academy of Child and Adolescent Psychiatry

    (2001)
  • A.G. Viana et al.

    Self-report measures in the study of comorbidity in children and adolescents with social phobia: research and clinical utility

    Journal of Anxiety Disorders

    (2008)
  • American Psychiatric Association

    Diagnostic and statistical manual of mental disorders

    (1994)
  • M.M. Antony et al.

    Psychometric properties of the 42-item and 21-item versions of the Depression Anxiety Stress Scales (DASS) in clinical groups and a community sample

    Psychological Assessment

    (1998)
  • D.H. Barlow

    Anxiety and its disorders: the nature and treatment of anxiety and panic

    (2002)
  • T. Bronisch et al.

    Suicidal ideation and suicide attempts: comorbidity with depression, anxiety disorders and substance abuse disorder

    European Archives of Psychiatry and Clinical Neuroscience

    (1994)
  • C. Brown et al.

    Treatment outcomes for primary care patients with major depression and lifetime anxiety disorders

    American Journal of Psychiatry

    (1996)
  • T.A. Brown et al.

    Dimensional versus categorical classification of mental disorders in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders and beyond: comment on the special section

    Journal of Abnormal Psychology

    (2005)
  • T.A. Brown et al.

    Current and lifetime comorbidity of the DSM-IV anxiety and mood disorders in a large clinical sample

    Journal of Abnormal Psychology

    (2001)
  • K.C. Burke et al.

    Age at onset of selected mental disorders in five community populations

    Archives of General Psychiatry

    (1990)
  • C. Caron et al.

    Comorbidity in child psychopathology: concepts, issues and research strategies

    Journal of Child Psychology and Psychiatry

    (1991)
  • D.A. Chavira et al.

    Child anxiety disorders in public systems of care: comorbidity and service utilization

    Journal of Behavioral Health Services and Research

    (2009)
  • L.A. Clark et al.

    Temperament, personality, and the mood and anxiety disorders.

    Journal of Abnormal Psychology

    (1994)
  • L.A. Clark

    Temperament as a unifying basis for personality and psychopathology

    Journal of Abnormal Psychology

    (2005)
  • Cited by (30)

    • Cognitive Behavioral Therapy for Children and Adolescents with Anxiety Disorders

      2023, Child and Adolescent Psychiatric Clinics of North America
    • Prevalence, comorbidity and predictors of anxiety disorders among children and adolescents

      2020, Asian Journal of Psychiatry
      Citation Excerpt :

      Another study found comorbidity between anxiety disorder and major depressive disorder (Wu et al., 2018). Leyfer et al. (2013) showed that 63% of the participants had comorbid anxiety or mood disorder and these findings supported this idea that anxiety and mood disorders may have common genetic, biological, and psychosocial damage (Leyfer et al., 2013). Another study also reported the comorbidity of post-traumatic stress disorder with depression and anxiety (Marthoenis et al., 2019).

    • Transdiagnostic exposure-based intervention for anxiety and depression in children and adolescents

      2020, Exposure Therapy for Children with Anxiety and OCD: Clinician's Guide to Integrated Treatment
    • Improvement in anxiety and depression symptoms following cognitive behavior therapy for pediatric obsessive compulsive disorder

      2019, Psychiatry Research
      Citation Excerpt :

      The relationship between OCD and anxiety and depression symptoms is not surprising. Anxiety and depression are collectively the most common mental health problems across development (Axelson and Birmaher, 2001; Costello et al., 2003a; Merikangas et al., 2010), and co-occur with each other at very high rates (up to 88%; Harrison et al., 2009; Leyfer et al., 2013; Moffitt et al., 2007; Sørensen et al., 2005). Anxiety and depression also share underlying genetic, neurobiological, and behavioral features with one another (Barlow et al., 2004; Bird et al., 2013; Clark and Watson, 1991; Drost et al., 2012) and with OCD (Bartz and Hollander, 2006; Carter et al., 2004; Graybiel and Rauch, 2000).

    • Developmental expression of anxiety and depressive behaviours after prenatal predator exposure and early life homecage enhancement

      2018, Behavioural Brain Research
      Citation Excerpt :

      Anxiety and depressive disorders are increasingly recognized as neurodevelopmental disorders, and critical childhood health concerns in their own right [1–5].

    View all citing articles on Scopus
    View full text