Original InvestigationRenal Denervation Prevents Heart Failure Progression Via Inhibition of the Renin-Angiotensin System
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Central Illustration
Key Words
acute myocardial infarction
brain type natriuretic peptide
coronary vascular reactivity
neprilysin
renin-angiotensin system
sympathetic nervous system
Abbreviations and Acronyms
BNP
B-type natriuretic peptide
HF
heart failure
LV
left ventricle/ventricular
MI/R
myocardial ischemia/reperfusion
NE
norepinephrine
NP
natriuretic peptide
RAS
renin-angiotensin system
RF
radiofrequency
RDN
renal denervation
SNS
sympathetic nervous system
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These studies were funded in part by a grant to Dr. Jenkins from the Ochsner Translational Medicine Research Initiative (OTMRI); and by National Institutes of General Medical Sciences (NIGMS) COBRE grant no. P30GM106392 to Dr. Kapusta. Drs. Polhemus and Lefer have a pending patent on the use of RDN therapy to treat cardiovascular diseases. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
© 2018 by the American College of Cardiology Foundation. Published by Elsevier.