Original InvestigationLeft Ventricular Unloading Before Reperfusion Promotes Functional Recovery After Acute Myocardial Infarction
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Central Illustration
Key Words
acute myocardial infarction
cardioprotection
ischemia-reperfusion injury
mechanical circulatory support
Abbreviations and Acronyms
AMI
acute myocardial infarction
BCL-2
B-cell lymphoma-2
BCL-XL
B-cell lymphoma–extra-large
BNP
B-type natriuretic peptide
CMR
cardiac magnetic resonance
DPP
dipeptidyl peptidase
LAD
left anterior descending
LGE
late-gadolinium enhancement
LV
left ventricular
MMP
matrix metalloproteinase
MRI
magnetic resonance imaging
mRNA
messenger ribonucleic acid
P-reperfusion
primary reperfusion
P-unloading
primary unloading
PCR
polymerase chain reaction
SDF
stromal-derived factor
RISK
reperfusion injury salvage kinase
RNA
ribonucleic acid
TV
transvalvular axial-flow
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This work was supported by a grant from the National Institutes of Health (RO1HL139785-01) to Dr. Kapur and Abiomed Inc. to Tufts Medical Center. Dr. Patel has received reimbursement for consulting services for Patient Management Advisory Council, Abiomed. Dr. Kapur has received institutional grant support and consulting and speaker honoraria from Abiomed Inc., Abbott Inc., Boston Scientific Inc., Medtronic Inc., Maquet/Getinge Inc., and Cardiac Assist. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.
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Drs. Esposito, Zhang, and Qiao contributed equally to this work and are joint first authors.
© 2018 Published by Elsevier on behalf of the American College of Cardiology Foundation