Original InvestigationANGPTL3 Deficiency and Protection Against Coronary Artery Disease
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This study was supported by grants from the National Heart, Lung, and Blood Institute (NHLBI) (R01HL131961 and K08HL114642 to Dr. Stitziel; R01 HL118744 to Dr. Musunuru; and R01 HL127564 and R21 HL120781 to Dr. Kathiresan); the National Human Genome Research Institute (U54HG003067 to Dr. Gabriel and Dr. Lander, UM1HG008895 to Dr. Kathiresan Dr. Gabriel, and Dr. Lander, and UM1HG008853 to Dr. Stitziel); the Barnes-Jewish Hospital Foundation (Dr. Stitziel); the Fannie Cox Prize for Excellence in Science Teaching, Harvard University (Dr. Musunuru); and the MGH Research Scholar Award (Dr. Kathiresan). PROMIS fieldwork has been supported through grants awarded to Dr. Saleheen, Dr. Danesh, and Dr. Frossard. Biomarker assays in PROMIS have been funded through grants awarded by the NHLBI (RC2HL101834 and RC1TW008485) and Fogarty International (RC1TW008485). This work was funded by the National Institutes of Health (NIH), which had no involvement in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, and approval of the manuscript. Dr. Stitziel has received a research grant from AstraZeneca; and consulting fees from Aegerion Pharmaceuticals. Dr. Khera is supported by an American College of Cardiology Foundation/Merck Cardiovascular Research Fellowship, a John S. Ladue Memorial Fellowship at Harvard Medical School, and a KL2/Catalyst Medical Research Investigator Training award from Harvard Catalyst funded by the NIH (TR001100); and has received consulting fees from Merck and Amarin. Dr. Klarin is supported by the NHLBI (T32 HL007734). Dr. Samani is supported by the British Heart Foundation and is a National Institute for Health Research Senior Investigator. Dr. Rader has received consulting fees from Aegerion Pharmaceuticals, Alnylam Pharmaceuticals, Eli Lilly and Company, Pfizer, Sanofi, and Novartis; is an inventor on a patent related to lomitapide that is owned by the University of Pennsylvania and licensed to Aegerion Pharmaceuticals; and is a cofounder of Vascular Strategies and Staten Biotechnology. Dr. Danesh has received funding from the UK Medical Research Council, British Heart Foundation, UK National Institute of Health Research (NIHR), NIHR Cambridge Comprehensive Biomedical Research, European Commission Framework Programme, European Research Council, GlaxoSmithKline, Merck, NHLBI, NHS Blood and Transplant, Novartis, Pfizer, Wellcome Trust, and UK Biobank. Dr. Saleheen has received grants from Pfizer, Regeneron, Eli Lilly, and Genentech. Dr. Kathiresan has received grants from Bayer Healthcare, Aegerion Pharmaceuticals, and Regeneron Pharmaceuticals; and consulting fees from Merck, Novartis, Sanofi, AstraZeneca, Alnylam Pharmaceuticals, Leerink Partners, Noble Insights, Quest Diagnostics, Genomics PLC, and Eli Lilly and Company; and holds equity in San Therapeutics and Catabasis Pharmaceuticals. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Drs. Stitziel, Khera, Wang, Saleheen, Musunuru, and Kathiresan contributed equally to this work.