The Present and Future
Review Topic of the Week
HIV and Ischemic Heart Disease

https://doi.org/10.1016/j.jacc.2016.09.979Get rights and content
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Abstract

The association of coronary heart disease (CHD) and human immunodeficiency virus (HIV) infection has been well recognized for many years. The etiology of the increased prevalence of CHD in HIV-infected populations is the result of complex interactions among the viral infection, host factors, traditional risk factors, and therapies for HIV. As the HIV population is living longer, largely attributable to combination antiretroviral therapy, there is concern about the effect of the rising prevalence of CHD on morbidity and mortality, as well its effect on health systems around the world. This review will highlight the epidemiological evidence linking HIV infection and CHD. It will also focus on our current understanding of the pathogenesis and factors associated with HIV infection and CHD. In addition, the review will highlight modes of presentation and management strategies for mitigating risk and treatment of HIV-positive patients presenting with CHD.

Key Words

acquired immunodeficiency syndrome
antiretroviral agents
atherosclerosis
coronary heart disease
drug interactions
myocardial infarction

Abbreviations and Acronyms

cART
combination antiretroviral therapy
CCTA
coronary computed tomography angiography
CHD
coronary heart disease
CIMT
carotid intima-media thickness
CVD
cardiovascular disease
MI
myocardial infarction
PI
protease inhibitor

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The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

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