Original InvestigationOff-Label Dosing of Non-Vitamin K Antagonist Oral Anticoagulants and Adverse Outcomes: The ORBIT-AF II Registry
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The ORBIT-AF registry was sponsored by Janssen Scientific Affairs, LLC. Dr. Steinberg has received research support from Janssen Scientific; and is a consultant for BMS-Pfizer. Dr. Ansell is a consultant for and advisory board member for Bristol-Myers Squibb, Pfizer, Janssen, Daiichi, Boehringer Ingelheim, and Alere. Dr. Fonarow is a consultant for and receives research support from Janssen. Dr. Gersh has received research support from and is an advisory board member of Medtronic, Baxter Healthcare Corporation, InspireMD, Cardiovascular Research Foundation, PPD Development, LP, Boston Scientific, and St. Jude. Dr. Kowey is a consultant for and advisory board member with Boehringer Ingelheim, Bristol-Myers Squibb, Johnson & Johnson, Portola, Merck, Sanofi, and Daiichi-Sankyo. Dr. Mahaffey has received research grants from Amgen, Daiichi, Johnson & Johnson, Medtronic, Merck, St. Jude Medical, Tenax; has received consulting fees from the American College of Cardiology, AstraZeneca, BAROnova, Bayer, Bio2Medical, Boehringer Ingelheim, Bristol-Myers Squibb, Cubist, Eli Lilly, Elsevier, Epson, Forest, Johnson & Johnson, and Medtronic; and has equity in BioPrintFitness. Dr. Peterson has received research support from Eli Lilly & Co., Janssen Pharmaceuticals, and American Heart Association; and is a consultant and advisory board member for Boehringer Ingelheim, Bristol-Myers Squibb, Janssen Pharmaceuticals, Pfizer, and Genentech Inc. Dr. Piccini has received research support from Johnson & Johnson, Janssen Pharmaceuticals, Bayer HealthCare Pharmaceuticals, Boston Scientific, Johnson & Johnson; and is a consultant and advisory board member for Forest Laboratories, Inc., Medtronic, Johnson & Johnson, and Janssen Pharmaceuticals. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.