The Present and FutureReview Topic of the WeekCirculating Biomarkers of Myocardial Fibrosis: The Need for a Reappraisal
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Key Words
biomarker
collagen
endomyocardial biopsy
fibrosis
heart failure
Abbreviations and Acronyms
CIVF
myocardial collagen type I volume fraction
CIIIVF
myocardial collagen type III volume fraction
CVF
collagen volume fraction
DCM
dilated cardiomyopathy
HF
heart failure
HHD
hypertensive heart disease
LV
left ventricular
LVAD
left ventricular assist device
MMP
matrix metalloproteinase
PICP
carboxy-terminal propeptide of procollagen type I
PIIINP
amino-terminal propeptide of procollagen type III
TGF
transforming growth factor
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This work was funded through the Ministry of Economy and Competitiveness, Spain (Instituto de Salud Carlos III grant RD12/0042/0009), and the European Commission FP7 Programme (MEDIA project grant FP7-HEALTH-2010-261409, EU-MASCARA project grant FP7-HEALTH-2011-278249, HOMAGE project grant FP7-HEALTH-2012-305507, and FIBRO-TARGETS project grant FP7-HEALTH-2013-602904). Dr. González is the recipient of a Ramón y Cajal contract from the Ministry of Economy and Competitiveness, Spain (RYC-2010-05797). The authors have reported that they have no relationships relevant to the contents of this paper to disclose.
Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.