Clinical ResearchImaging and BiomarkersThe Utility of Cardiac Biomarkers, Tissue Velocity and Strain Imaging, and Cardiac Magnetic Resonance Imaging in Predicting Early Left Ventricular Dysfunction in Patients With Human Epidermal Growth Factor Receptor II–Positive Breast Cancer Treated With Adjuvant Trastuzumab Therapy
Imaging and Biomarkers
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Key Words
biomarkers
breast cancer
cardiac MRI
cardiomyopathy
doxorubicin
strain
tissue velocity imaging
trastuzumab
Abbreviations and Acronyms
a′
late diastolic annular velocity of the lateral wall
AC
adriamycin and cyclophosphamide
BNP
brain natriuretic peptide
CHF
congestive heart failure
CM
cardiomyopathy
CRP
C-reactive protein
CV
coefficient of variation
e′
early diastolic annular velocity of the lateral left ventricular wall
FEC
fluorouracil, epirubicin, and cyclophosphamide
LGE
late gadolinium enhancement
LV
left ventricle/ventricular
LVEF
left ventricular ejection fraction
MRI
magnetic resonance imaging
NPV
negative predictive value
PPV
positive predictive value
S′
systolic annular velocity of the lateral left ventricular wall
TnT
troponin T
TTE
transthoracic echocardiography
TVI
tissue velocity imaging
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The present study was supported by the Manitoba Medical Services Foundation, St. Boniface General Hospital and Research Foundation, and the Health Sciences Centre Research Foundation. Mr. Walker is a recipient of the Manitoba Health and Research Council studentship award. Dr. Singal is the holder of the Naranjan S. Dhalla chair in Cardiovascular Research supported by the St. Boniface Hospital and Research Foundation. Dr. Jassal is the recipient of the Heart and Stroke Foundation New Investigator award. All other authors have reported that they have no relationships to disclose.
Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.