Journal of the American Academy of Child & Adolescent Psychiatry
ReviewSystematic Review and Meta-analysis: Mental Health in Children With Neurogenetic Disorders Associated With Intellectual Disability
Section snippets
Method
This review was structured and executed according to the PRISMA checklist (Figure 1).22
Results
The initial search yielded 2,301 records, of which 39 were suitable for inclusion. The resulting pool of articles contained data for 4,039 children and adolescents.
Discussion
Prevalence studies of psychiatric diagnoses in children and adolescents with a neurogenetic disorder associated with ID are relatively sparse, but estimates appeared to be higher than in the general population. We found data to indicate that 8% of children with Down syndrome and 20% of children with Prader-Willi syndrome were diagnosed with any disruptive disorder, higher than the worldwide pooled prevalence of 5.7% for children and adolescents in the general population.75 Our pooled prevalence
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Cited by (0)
The authors have acknowledged seed funding from the Telethon Kids Institute, Perth, Australia, and the Western Australian Department of Health, Perth, Australia, who supported this study with a Merit Award.
Mr. Jacoby served as the statistical expert for this research.
Disclosure: Drs. Leonard and Downs have consulted for AveXis, GW Pharmaceuticals, Anavex, and Marinus Pharmaceuticals. Drs. Glasson, Chen, Skoss, Blackmore, Mr. Buckley, Ms. Epstein, Mr. Jacoby, and Ms. Bourke have reported no biomedical financial interests or potential conflicts of interest.