Elsevier

European Urology

Volume 68, Issue 5, November 2015, Pages 891-898
European Urology

Prostate Cancer
Development of a Standardized Set of Patient-centered Outcomes for Advanced Prostate Cancer: An International Effort for a Unified Approach

https://doi.org/10.1016/j.eururo.2015.06.007Get rights and content
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Abstract

Background

There are no universally monitored outcomes relevant to men with advanced prostate cancer, making it challenging to compare health outcomes between populations.

Objective

We sought to develop a standard set of outcomes relevant to men with advanced prostate cancer to follow during routine clinical care.

Design, setting, and participants

The International Consortium for Health Outcomes Measurement assembled a multidisciplinary working group to develop the set.

Outcome measurements and statistical analysis

We used a modified Delphi method to achieve consensus regarding the outcomes, measures, and case mix factors included.

Results and limitations

The 25 members of the multidisciplinary international working group represented academic and nonacademic centers, registries, and patients. Recognizing the heterogeneity of men with advanced prostate cancer, the group defined the scope as men with all stages of incurable prostate cancer (metastatic and biochemical recurrence ineligible for further curative therapy). We defined outcomes important to all men, such as overall survival, and measures specific to subgroups, such as time to metastasis. Measures gathered from clinical data include measures of disease control. We also identified patient-reported outcome measures (PROMs), such as degree of urinary, bowel, and erectile dysfunction, mood symptoms, and pain control.

Conclusions

The international multidisciplinary group identified clinical data and PROMs that serve as a basis for international health outcome comparisons and quality-of-care assessments. The set will be revised annually.

Patient summary

Our international group has recommended a standardized set of patient-centered outcomes to be followed during routine care for all men with advanced prostate cancer.

Keywords

Outcome assessment (health care)
Patient-centered care
Prostate cancer
Quality indicators
Health care
Palliative care

Cited by (0)

These authors contributed equally to this work.