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Quality of life in schizophrenia and bipolar disorder: The impact of symptomatic remission and resilience

Published online by Cambridge University Press:  23 March 2020

A. Hofer ,
Y. Mizuno ,
F. Wartelsteiner ,
W. Wolfgang Fleischhacker ,
B. Frajo-Apor ,
G. Kemmler ,
M. Mimura ,
S. Pardeller ,
C. Sondermann  and
T. Suzuki
...Show all authors
A. Hofer*
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
Y. Mizuno
Affiliation:
Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan Institute of Psychiatry, Psychology and Neuroscience, King's College London, Department of Psychosis Studies, London, UK
F. Wartelsteiner
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
W. Wolfgang Fleischhacker
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
B. Frajo-Apor
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
G. Kemmler
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
M. Mimura
Affiliation:
Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
S. Pardeller
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
C. Sondermann
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
T. Suzuki
Affiliation:
Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
A. Welte
Affiliation:
Medical University Innsbruck, Department of Psychiatry, Psychotherapy and Psychosomatics, Division of Psychiatry I, Anichstr. 35, 6020Innsbruck, Austria
H. Uchida
Affiliation:
Keio University School of Medicine, Department of Neuropsychiatry, Tokyo, Japan
*
* Corresponding author. E-mail address:a.hofer@i-med.ac.at (A. Hofer).
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Abstract

Background:

Health-related quality of life (HRQOL) is significantly affected in individuals with schizophrenia or bipolar I disorder (BD-I). The current study investigated whether symptomatic remission and resilience might differently impact HRQOL in these patients.

Methods:

Fifty-two patients with schizophrenia and 60 patients suffering from BD-I from outpatient mental health services as well as 77 healthy control subjects from the general community were included into a cross-sectional study. HRQOL and resilience were assessed using the WHOQOL-BREF and the Resilience Scale. In patients, psychopathology was quantified by the Positive and Negative Syndrome Scale or the Montgomery Asberg Depression Rating Scale and the Young Mania Rating Scale, respectively.

Results:

Notably, both patient groups showed lower HRQOL and resilience compared to control subjects, non-remitted patients indicated lower HRQOL than remitted ones. The effect of remission on HRQOL was significantly larger in patients with BD-I than in those with schizophrenia but did not explain the difference in HRQOL between groups. Resilience predicted HRQOL in all three groups. When accounting for the effect of resilience among remitted patients, only the difference in HRQOL between schizophrenia patients and control subjects was significant.

Conclusion:

These findings demonstrate the impact of symptomatic remission and resilience on HRQOL of both patients suffering from schizophrenia and BD-I and indicate that these factors are especially relevant for HRQOL of patients with BD-I.

Keywords

Quality of lifeSchizophreniaBipolar disorderRemissionResilience
Type
Original article
Information
European Psychiatry , Volume 46 , October 2017 , pp. 42 - 47
Copyright
Copyright © European Psychiatric Association 2017

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References

The WHOQOL Group. The World Health Organization Quality of Life Assessment (WHOQOL): position paper from The World Health Organization. Soc Sci Med 1995;41(10): 1403–1409.CrossRefGoogle Scholar
Cook, ELHarman, JSA comparison of health-related quality of life for individuals with mental health disorders and common chronic medical conditions. Public Health Rep 2008;123(1): 45–51.CrossRefGoogle ScholarPubMed
Eack, SMNewhill, CEPsychiatric symptoms and quality of life in schizophrenia: a meta-analysis. Schizophr Bull 2007;33(5): 1225–1237.CrossRefGoogle ScholarPubMed
Ishak, WWBrown, KAye, SSKahloon, MMobaraki, SHanna, RHealth-related quality of life in bipolar disorder. Bipolar Disord 2012;14(1): 6–18.CrossRefGoogle ScholarPubMed
Michalak, EEYatham, LNLam, RWQuality of life in bipolar disorder: a review of the literature. Health Qual Life Outcomes 2005;3:72.CrossRefGoogle ScholarPubMed
Saarni, SIViertiö, SPerälä, JKoskinen, SLönnqvist, JSuvisaari, JQuality of life of people with schizophrenia, bipolar disorder and other psychotic disorders. Br J Psychiatry 2010;197(5): 386–394.CrossRefGoogle ScholarPubMed
Alessandrini, MLançon, CFond, GFaget-Agius, CRichieri, RFaugere, M, et al.A structural equation modelling approach to explore the determinants of quality of life in schizophrenia. Schizophr Res 2016;171(1–3):27–34.CrossRefGoogle Scholar
Casey, DARodriguez, MNorthcott, CVickar, GShihabuddin, LSchizophrenia: medical illness, mortality, and aging. Int J Psychiatry Med 2011;41(3): 245–251.CrossRefGoogle ScholarPubMed
Fleischhacker, WWRabinowitz, JKemmler, GEerdekens, MMehnert, APerceived functioning, well-being and psychiatric symptoms in patients with stable schizophrenia treated with long-acting risperidone for 1 year. Br J Psychiatry 2005;187(2): 131–136.CrossRefGoogle ScholarPubMed
Masten, ASResilience in children threatened by extreme adversity: frameworks for research, practice, and translational synergy. Dev Psychopathol 2011;23(2): 493–506.CrossRefGoogle ScholarPubMed
Hofer, AMizuno, YFrajo-Apor, BKemmler, GSuzuki, TPardeller, S, et al.Resilience, internalized stigma, self-esteem, and hopelessness among people with schizophrenia: cultural comparison in Austria and Japan. Schizophr Res 2016;171(1–3):86–91.CrossRefGoogle ScholarPubMed
Torgalsboen, AKFu, SCzajkowski, N. Does resilience contribute to full recovery in first-episode schizophrenia? Poster presented at the 5th Biennial Schizophrenia International Research Society Conference, 2016; 2-6 April, Florence, Italy.Google Scholar
Chiu, MYHo, WWLo, WTYiu, MGOperationalization of the SAMHSA model of recovery: a quality of life perspective. Qual Life Res 2010;19(1): 1–13.CrossRefGoogle ScholarPubMed
Ho, WWChiu, MYLo, WTYiu, MGRecovery components as determinants of the health-related quality of life among patients with schizophrenia: structural equation modelling analysis. Aust N Z J Psychiatry 2010;44(1): 71–84.CrossRefGoogle ScholarPubMed
Mizuno, YHofer, ASuzuki, TFrajo-Apor, BWartelsteiner, FKemmler, G, et al.Clinical and biological correlates of resilience in patients with schizophrenia and bipolar disorder: a cross-sectional study. Schizophr Res 2016;175(1–3):148–153.CrossRefGoogle ScholarPubMed
Wartelsteiner, FMizuno, YFrajo-Apor, BKemmler, GPardeller, SSondermann, C, et al.Quality of life in stabilized schizophrenia patients is mainly associated with resilience and self-esteem. Acta Pyschiatr Scand 2016;134(4): 360–367.CrossRefGoogle ScholarPubMed
Sheehan, DVLecrubier, YSheehan, KHAmorim, PJanavs, JWeiller, E, et al.The Mini-international neuropsychiatric interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 1998;59(Suppl. 20):22–33.Google ScholarPubMed
Power, MHarper, ABullinger, MThe World Health Organization WHOQOL-100: tests of the universality of quality of life in 15 different cultural groups worldwide. Health Psychol 1999;18(5): 495–505.CrossRefGoogle ScholarPubMed
The WHOQOL Group. Development of the World Health Organization WHOQOL-BREF quality of life assessment. Psychol Med 1998;28(3): 551–558.CrossRefGoogle Scholar
Wagnild, GMYoung, HMDevelopment and psychometric evaluation of the resilience scale. J Nurs Meas 1993;1(2): 165–178.Google ScholarPubMed
Schumacher, JLeppert, KGunzelmann, TStrauß, BBrähler, EDie Resilienzskala - Ein Fragebogen zur Erfassung der psychischen Widerstandsfähigkeit als Personenmerkmal. Z f Klin Psychol Psychiatr Psychother 2005;53(1): 16–39.Google Scholar
Kay, SRFiszbein, AOpler, LAThe Positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13(2): 261–276.CrossRefGoogle Scholar
Montgomery, SAAsberg, MA new depression scale designed to be sensitive to change. Br J Psychiatry 1979;134(4): 382–389.CrossRefGoogle ScholarPubMed
Young, RCBiggs, JTZiegler, VEMeyer, DAA rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 1978;133(5): 429–435.CrossRefGoogle ScholarPubMed
Andreasen, NCCarpenter, WT Jr.Kane, JMLaser, RAMarder, SRWeinberger, DRRemission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry 2005;162(3): 441–449.CrossRefGoogle ScholarPubMed
Yalcin-Siedentopf, NHoertnagl, CMBiedermann, FBaumgartner, SDeisenhammer, EAHausmann, A, et al.Facial affect recognition in symptomatically remitted patients with schizophrenia and bipolar disorder. Schizophr Res 2014;152(2–3):440–445.CrossRefGoogle ScholarPubMed
Brown, Shttp://www.BrownMath.com/stat/shape.htm; 2015 [accessed 06.04.17].Google Scholar
Levin, JRSerlin, RCSeaman, MAA controlled, powerful multiple-comparison strategy for several situations. Psychol Bull 1994;115(1): 153–159.CrossRefGoogle Scholar
Sum, MYHo, NFSim, KCross diagnostic comparisons of quality of life deficits in remitted and unremitted patients with schizophrenia and bipolar disorder. Schizophr Res 2015;168(1–2):191–196.CrossRefGoogle ScholarPubMed
Chino, BNemoto, TFujii, CMizuno, MSubjective assessments of the quality of life, well-being and self-efficacy in patients with schizophrenia. Psychiatry Clin Neurosci 2009;63(4): 521–528.CrossRefGoogle ScholarPubMed
Hoertnagl, CMBiedermann, FYalcin-Siedentopf, NMuehlbacher, MRauch, ABaumgartner, S, et al.Prosodic and semantic affect perception in remitted patients with bipolar I disorder. J Clin Psychiatry 2015;76(6):e779–e786.CrossRefGoogle ScholarPubMed
Brissos, SDias, VVBalanzá-Martinez, VCarita, AIFigueira, MLSymptomatic remission in schizophrenia patients: relationship with social functioning, quality of life, and neurocognitive performance. Schizophr Res 2011;129(2–3):133–136.CrossRefGoogle ScholarPubMed
Goossens, PJHartong, EGKnoppert-van der Klein, EAvan Achterberg, TSelf-reported psychopathological symptoms and quality of life in outpatients with bipolar disorder. Perspect Psychiatr Care 2008;44(4): 275–284.CrossRefGoogle ScholarPubMed
Jaracz, KGórna, KKiejda, JGrabowska-Fudala, BJaracz, JSuwalska, A, et al.Psychosocial functioning in relation to symptomatic remission: a longitudinal study of first episode schizophrenia. Eur Psychiatry 2015;30(8): 907–913.CrossRefGoogle ScholarPubMed
Karadayi, GEmiroğlu, BUçok, ARelationship of symptomatic remission with quality of life and functionality in patients with schizophrenia. Compr Psychiatry 2011;52(6): 701–707.CrossRefGoogle ScholarPubMed
Wright, MODMasten, ASNayaran, AJResilience process in development: four waves of research on positive adaptation in the context of adversity. In: Goldstein, SBrooks, RB, editors. Handbook of resilience in children. 2nd ed., New York, NY: Springer; 2013. p. 15–37.CrossRefGoogle Scholar
Echezarraga, ACalvete, EGonzález-Pinto, AMLas Hayas, C Resilience dimensions and mental health outcomes in bipolar disorder in a follow-up study. Stress Health. http://dx.doi.org/10.1002/smi.2767.CrossRefGoogle Scholar
Murray, GSuto, MHole, RHale, SAmari, EMichalak, EESelf-management strategies used by “high functioning” individuals with bipolar disorder: from research to clinical practice. Clin Psychol Psychother 2011;18(2): 95–109.CrossRefGoogle ScholarPubMed
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