Hostname: page-component-8448b6f56d-wq2xx Total loading time: 0 Render date: 2024-04-25T05:37:29.970Z Has data issue: false hasContentIssue false
  • English
  • Français

Lower availability of midbrain serotonin transporter between healthy subjects with and without a family history of major depressive disorder – a preliminary two-ligand SPECT study

Published online by Cambridge University Press:  15 April 2020

P.C. Hsieh ,
K.C. Chen ,
T.L. Yeh ,
I.H. Lee ,
P.S. Chen ,
W.J. Yao ,
N.-T. Chiu ,
C.-C. Chen ,
M.-H. Liao  and
Y.K. Yang
P.C. Hsieh
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan
K.C. Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
T.L. Yeh
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
I.H. Lee
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
P.S. Chen
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan Department of Psychiatry, National Cheng Kung University Hospital, Dou-Liou Branch, Yunlin, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan
W.J. Yao
Affiliation:
Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
N.-T. Chiu
Affiliation:
Department of Nuclear Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
C.-C. Chen
Affiliation:
Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, Taoyuan, Taiwan
M.-H. Liao
Affiliation:
Institute of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, Taoyuan, Taiwan
Y.K. Yang*
Affiliation:
Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 138, Sheng Li road, North Dist., 70403Tainan, Taiwan Addiction Research Center, National Cheng Kung University, Tainan, Taiwan Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan
*
*Corresponding author. Tel.: +886 6 2353535×5213; fax: +886 6 2759259. E-mail address:ykyang@mail.ncku.edu.tw (Y.K. Yang).
Get access

Abstract

Purpose

Serotonin transporter (SERT) and dopamine transporter (DAT) levels differ in patients with major depressive disorder (MDD) who are in a depressed state in comparison with healthy controls. In addition, a family history of depression is a potent risk factor for developing depression, and inherited vulnerability to serotonergic and dopaminergic dysfunction is suspected in this. The aim of this study was to examine the availabilities of midbrain SERT and striatal DAT in healthy subjects with and without a first-degree family history of MDD.

Methods

Eight healthy subjects with first-degree relatives with MDD and 16 sex- and age-matched healthy controls were recruited. The availabilities of SERT and DAT were approximated using SPECT, employing [123I] 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM) and [99mTc] TRODAT-1 as the ligands, respectively. There are missing data for one participant with a first-degree family history of MDD from the ADAM study, due to a lack of the radio-ligand at the time of experiment.

Results

SERT availability in the midbrain was significantly lower in subjects with a first-degree family history of MDD than in healthy subjects. However, DAT availability was no different between two groups.

Conclusions

The results with regard to the midbrain SERT level suggest the heritability of MDD.

Keywords

Serotonin transporterDopamine transporterSPECTFamily history of major depressive disorder
Type
Original article
Information
European Psychiatry , Volume 29 , Issue 7 , September 2014 , pp. 414 - 418
Copyright
Copyright © 2013 Elsevier Masson SAS

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Benkelfat, C., Ellenbogen, M.A., Dean, P., Palmour, R.M., Young, S.N.Mood-lowering effect of tryptophan depletion. Enhanced susceptibility in young men at genetic risk for major affective disorders. Arch Gen Psychiatry 1994;51:687–697.CrossRefGoogle ScholarPubMed
Brunswick, D.J., Amsterdam, J.D., Mozley, P.D., Newberg, A.Greater availability of brain dopamine transporters in major depression shown by [99m Tc]TRODAT-1 SPECT imaging. Am J Psychiatry 2003;160:1836–1841.CrossRefGoogle Scholar
Cannon, D.M., Ichise, M., Rollis, D., Klaver, J.M., Gandhi, S.K., Charney, D.S.et al.Elevated serotonin transporter binding in major depressive disorder assessed using positron emission tomography and [11C]DASB; comparison with bipolar disorder. Biol Psychiatry 2007;62:870–877.CrossRefGoogle Scholar
Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H.et al.Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386–389.CrossRefGoogle ScholarPubMed
Catafau, A.M., Perez, V., Penengo, M.M., Bullich, S., Danus, M., Puigdemont, D.et al.SPECT of serotonin transporters using 123I-ADAM: optimal imaging time after bolus injection and long-term test-retest in healthy volunteers. J Nucl Med 2005;46:1301–1309.Google ScholarPubMed
Chang, L.T.Method for attenuation correction in radionuclide computed tomography. IEEE Trans Nucl Sci 1978;25:638–643.CrossRefGoogle Scholar
Chen, P.S., Yeh, T.L., Lee, I.H., Lin, C.B., Tsai, H.C., Chen, K.C.et al.Effects of C825T polymorphism of the GNB3 gene on availability of dopamine transporter in healthy volunteers--a SPECT study. Neuroimage 2011;56:1526–1530.CrossRefGoogle Scholar
Chou, Y.H., Yang, B.H., Chung, M.Y., Chen, S.P., Su, T.P., Chen, C.C.et al.Imaging the serotonin transporter using (123)I-ADAM in the human brain. Psychiatry Res 2009;172:38–43.CrossRefGoogle ScholarPubMed
Erlandsson, K., Sivananthan, T., Lui, D., Spezzi, A., Townsend, C.E., Mu, S.et al.Measuring SSRI occupancy of SERT using the novel tracer [123I]ADAM: a SPECT validation study. Eur J Nucl Med Mol Imaging 2005;32:1329–1336.CrossRefGoogle ScholarPubMed
Frokjaer, V.G., Pinborg, L.H., Madsen, J., de Nijs, R., Svarer, C., Wagner, A.et al.Evaluation of the serotonin transporter ligand 123I-ADAM for SPECT studies on humans. J Nucl Med 2008;49:247–254.CrossRefGoogle ScholarPubMed
Frokjaer, V.G., Vinberg, M., Erritzoe, D., Svarer, C., Baare, W., Budtz-Joergensen, E.et al.High familial risk for mood disorder is associated with low dorsolateral prefrontal cortex serotonin transporter binding. Neuroimage 2009;46:360–366.CrossRefGoogle ScholarPubMed
Hamilton, M.A rating scale for depression. J Neurol Neurosurg Psychiatry 1960;23:56–62.CrossRefGoogle ScholarPubMed
Hsieh, P.C., Lee, I.H., Yeh, T.L., Chen, K.C., Huang, H.C., Chen, P.S.et al.Distribution volume ratio of serotonin and dopamine transporters in euthymic patients with a history of major depression – a dual-isotope SPECT study. Psychiatry Res 2010;184:157–161.CrossRefGoogle ScholarPubMed
Hwang, W.J., Yao, W.J., Wey, S.P., Ting, G.Reproducibility of 99mTc-TRODAT-1 SPECT measurement of dopamine transporters in Parkinson's disease. J Nucl Med 2004;45:207–213.Google ScholarPubMed
Joensuu, M., Tolmunen, T., Saarinen, P.I., Tiihonen, J., Kuikka, J., Ahola, P.et al.Reduced midbrain serotonin transporter availability in drug-naive patients with depression measured by SERT-specific [(123)I] nor-beta-CIT SPECT imaging. Psychiatry Res 2007;154:125–131.CrossRefGoogle ScholarPubMed
Kendler, K.S., Gatz, M., Gardner, C.O., Pedersen, N.L.A Swedish national twin study of lifetime major depression. Am J Psychiatry 2006;163:109–114.CrossRefGoogle ScholarPubMed
Lee, Y., Yang, M.J., Lai, T.J.et al.Development of the Taiwanese Depression Questionnaire. Chang Geng Med J 2000;23:688–694.Google ScholarPubMed
Lehto, S., Tolmunen, T., Joensuu, M., Saarinen, P.I., Vanninen, R., Ahola, P.et al.Midbrain binding of [123I]nor-beta-CIT in atypical depression. Prog Neuropsychopharmacol Biol Psychiatry 2006;30:1251–1255.CrossRefGoogle Scholar
Meyer, J.H.Imaging the serotonin transporter during major depressive disorder and antidepressant treatment. J Psychiatry Neurosci 2007;32:86–102.Google ScholarPubMed
Meyer, J.H., Ginovart, N., Boovariwala, A., Sagrati, S., Hussey, D., Garcia, A.et al.Elevated monoamine oxidase a levels in the brain: an explanation for the monoamine imbalance of major depression. Arch Gen Psychiatry 2006;63:1209–1216.CrossRefGoogle ScholarPubMed
Meyer, J.H., Houle, S., Sagrati, S., Carella, A., Hussey, D.F., Ginovart, N.et al.Brain serotonin transporter binding potential measured with carbon 11-labeled DASB positron emission tomography: effects of major depressive episodes and severity of dysfunctional attitudes. Arch Gen Psychiatry 2004;61:1271–1279.CrossRefGoogle ScholarPubMed
Miller, M.A., Rahe, R.H.Life changes scaling for the 1990s. J Psychosom Res 1997;43:279–292.CrossRefGoogle ScholarPubMed
Neumeister, A., Willeit, M., Praschak-Rieder, N., Asenbaum, S., Stastny, J., Hilger, E.et al.Dopamine transporter availability in symptomatic depressed patients with seasonal affective disorder and healthy controls. Psychol Med 2001;31:1467–1473.CrossRefGoogle ScholarPubMed
Newberg, A.B., Amsterdam, J.D., Wintering, N., Ploessl, K., Swanson, R.L., Shults, J.et al.123I-ADAM binding to serotonin transporters in patients with major depression and healthy controls: a preliminary study. J Nucl Med 2005;46:973–977.Google ScholarPubMed
Pai, L., Wen, H.C., Lu, R.B., Kuo, M.L.The questionnaire of life stress cognition of adults-revised (full text in Chinese). Chinese J Ment Health 1985;3:195–205.Google Scholar
Parsey, R.V., Hastings, R.S., Oquendo, M.A., Huang, Y.Y., Simpson, N., Arcement, J.et al.Lower serotonin transporter binding potential in the human brain during major depressive episodes. Am J Psychiatry 2006;163:52–58.CrossRefGoogle ScholarPubMed
Rahe, R.H.Epidemiological studies of life change and illness. Int J Psychiatry Med 1975;6:133–146.CrossRefGoogle ScholarPubMed
Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E.et al.The Mini-International Neuropsychiatric Interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59Suppl. 201998 22–33 [quiz 4-57].Google ScholarPubMed
Staley, J.K., Sanacora, G., Tamagnan, G., Maciejewski, P.K., Malison, R.T., Berman, R.M.et al.Sex differences in diencephalon serotonin transporter availability in major depression. Biol Psychiatry 2006;59:40–47.CrossRefGoogle ScholarPubMed
Sullivan, P.F., Neale, M.C., Kendler, K.S.Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000;157:1552–1562.CrossRefGoogle ScholarPubMed
van der Veen, F.M., Evers, E.A., Deutz, N.E., Schmitt, J.A.Effects of acute tryptophan depletion on mood and facial emotion perception related brain activation and performance in healthy women with and without a family history of depression. Neuropsychopharmacology 2007;32:216–224.CrossRefGoogle ScholarPubMed
Volkow, N.D., Fowler, J.S., Wang, G.J., Logan, J., Schlyer, D., MacGregor, R.et al.Decreased dopamine transporters with age in health human subjects. Ann Neurol 1994;36:237–239.CrossRefGoogle ScholarPubMed
Yang, Y.K., Yeh, T.L., Yao, W.J., Lee, I.H., Chen, P.S., Chiu, N.T.et al.Greater availability of dopamine transporters in patients with major depression--a dual-isotope SPECT study. Psychiatry Res 2008;162:230–235.CrossRefGoogle ScholarPubMed
Yeh, T.L., Lee, I.H., Chen, K.C., Chen, P.S., Yao, W.J., Yang, Y.K.et al.The relationships between daily life events and the availabilities of serotonin transporters and dopamine transporters in healthy volunteers--a dual-isotope SPECT study. Neuroimage 2009;45:275–279.CrossRefGoogle Scholar
Submit a response

Comments

No Comments have been published for this article.