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Neurodevelopmental markers in different psychopathological dimensions of first episode psychosis: The ESPIGAS Study

Published online by Cambridge University Press:  16 April 2020

Miguel Ruiz-Veguilla ,
Jorge A. Cervilla ,
Maria Luisa Barrigón ,
Maite Ferrín ,
Blanca Gutiérrez ,
Estibaliz Gordo ,
Manuel Anguita ,
Antía Brañas ,
Jesús Fernández-Logroño  and
Manuel Gurpegui
Miguel Ruiz-Veguilla
Affiliation:
First Episode and Early Onset Psychosis Unit, Unidad de Psiquiatria, Hospital Neurotraumatológico, Complejo Hospitalario de Jaen, E-23009Jaen, Spain
Jorge A. Cervilla*
Affiliation:
Departamento de Medicina Legal, Toxicología y Psiquiatría, Instituto de Neurociencias, Facultad de Medicina, Universidad de Granada, Avenida de Madrid, 11, E-18071Granada, Spain
Maria Luisa Barrigón
Affiliation:
Hospital Clínico San Cecilio, Avda. del Dr. Oloriz n°16, E-18012Granada, Spain
Maite Ferrín
Affiliation:
Unidad de Psiquiatria, Hospital Neurotraumatológico, Unidad de Salud Mental Infanto-juvenil, Avenida, Doctor Olóriz 16, Complejo Hospitalario de Jaen, E-23009Jaen, Spain
Blanca Gutiérrez
Affiliation:
Departamento de Medicina Legal, Toxicología y Psiquiatría, Instituto de Neurociencias, Facultad de Medicina, Universidad de Granada, Avenida de Madrid, 11, E-18071Granada, Spain
Estibaliz Gordo
Affiliation:
Hospital Clínico San Cecilio, Avda. del Dr. Oloriz n°16, E-18012Granada, Spain
Manuel Anguita
Affiliation:
Hospital Clínico San Cecilio, Avda. del Dr. Oloriz n°16, E-18012Granada, Spain
Antía Brañas
Affiliation:
Hospital Clínico San Cecilio, Avda. del Dr. Oloriz n°16, E-18012Granada, Spain
Jesús Fernández-Logroño
Affiliation:
Hospital Clínico San Cecilio, Avda. del Dr. Oloriz n°16, E-18012Granada, Spain
Manuel Gurpegui
Affiliation:
Departamento de Medicina Legal, Toxicología y Psiquiatría, Instituto de Neurociencias, Facultad de Medicina, Universidad de Granada, Avenida de Madrid, 11, E-18071Granada, Spain
*
*Corresponding author. Tel./fax: +34 958 241 017. E-mail address: mruizveguilla@yahoo.com (M. Ruiz-Veguilla), jacb@ugr.es (J.A. Cervilla), marisabe@gmail.com (M.L. Barrigón), maiteferrin@yahoo.es (M. Ferrín), blancag@ugr.es (B. Gutiérrez), estibalizgordo@hotmail.com (E. Gordo), maroceano77@yahoo.es (M. Anguita), antiabg@gmail.com (A. Brañas), jflogrono@gmail.com (J. Fernández-Logroño), gurpegui@ugr.es (M. Gurpegui).
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Abstract

Objective

The main aim of this study was to explore whether specific groups of patients with first episode non-affective psychosis could be identified on a psychopathological basis and, then, whether such identified groups could be validated by exploring their correlation with a variety of neurodevelopmental markers.

Method

Eighty-seven patients with a first episode of non-affective psychotic disorder were consecutively recruited. We assessed psychopathology and neurological soft signs using the PANSS and the Neurological Evaluation Scale, respectively. We collected information on obstetric complications, premorbid adjustment and family history.

Results

All PANSS symptoms were analysed using principal component analysis and four factors were obtained (negative, disorganization, positive and paranoid). Subsequently, the four factors were subjected to a cluster analysis where three groups emerged: “paranoid” (n = 40), “low score” (n = 29) and “negative” (n = 18) subtype. After adjusting by sex and age, we found that the “negative group” had poorer social premorbid adjustment, worse verbal fluency and higher prevalence of both obstetric complications and neurological soft signs, when compared with the “low score” group. Similarly, the “negative group” showed significantly poorer social premorbid adjustment and higher number of neurological soft signs than the “paranoid group”.

Conclusions

Our results support that, among non-affective first onset psychotic patients, those with predominant negative symptoms are more likely to correlate with higher presence of neurodevelopmental markers.

Keywords

First episode psychosisNeurodevelopmentalNeurological soft signsCluster analysis
Type
Original article
Information
European Psychiatry , Volume 23 , Issue 8 , December 2008 , pp. 533 - 540
Copyright
Copyright © Elsevier Masson SAS 2008

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