Clinical InvestigationSystolic Left Ventricular Mechanics and FunctionAge-Related Normal Range of Left Ventricular Strain and Torsion Using Three-Dimensional Speckle-Tracking Echocardiography
Section snippets
Study Subjects
In protocol 1, we studied 19 patients who underwent clinically indicated CMR examinations and agreed to undergo RT3DE studies on the same day. In protocol 2, 335 normal subjects (mean age, 36 ± 22 years; range, 1–88 years; 170 male subjects) were enrolled to obtain RT3DE data sets. Eligibility criteria included (1) normal blood pressure with no history of hypertension and (2) absence of diabetes and/or cardiovascular disease. Subjects who were primarily hospital employees, their relatives,
Results
Acquisition of RT3DE data sets was feasible in all subjects in both protocols. The time required for analysis, including endocardial initialization, correction of boundaries, and computation of LV strain, was <5 min.
Discussion
The major findings of this study were as follows: (1) longitudinal and circumferential strain measured by RT3DE imaging correlated well with strain values derived from CMR images using the feature-tracking algorithm,16 and the correlation for radial strain was only modest; (2) significant age dependency of longitudinal, radial, and 3D strain values was observed at the basal, middle, and apical levels of the left ventricle; (3) LV rotation, twist, and torsion demonstrated significant age
Conclusions
Our results provide initial validation of 3D strain analysis from RT3DE images, as well as normal reference values for the different components of LV strain and torsion. Age-related differences in strains and torsion may reflect the maturational and aging process of the myocardium.
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Normal Values of Left Ventricular Size and Function on Three-Dimensional Echocardiography: Results of the World Alliance Societies of Echocardiography Study
2022, Journal of the American Society of EchocardiographyCitation Excerpt :Radial strain showed the poorest correlation with sonomicrometric approaches36 and therefore was not included in the 3D speckle-tracking analysis. Three-dimensional longitudinal and circumferential strain have been studied in the normal population by several investigators,28,31,37 providing conflicting results. More than one study has suggested that 3D GLS is higher in magnitude in women than in men whereas GCS is not.28,30
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2021, Current Problems in CardiologyCitation Excerpt :Also, the majority of the lesions in the proximal vessels covering larger territories revealed GLS values in the abnormal range. Although other conditions such as heart failure, hypertension, chronic kidney disease, or age itself14,18-21 may impair GLS, on multivariate logistic regression data analysis, an abnormal LV GLS was associated with a significant increase in the risk of admissions for MACE within 2 years (OR 1.06, P<0.05, CI 95% 1.005-1.120) as well as cardiac mortality (OR 1.12, P<0.05, CI 95% (Table 4; Figs 2 and 3). An explanation to these findings could be that a “low-grade” ischemia may be causing early “silent” systolic dysfunction.
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2020, Journal of the American Society of Echocardiography
Dr Michael H. Picard served as guest editor for this report.