Transference focused psychotherapy: Development of a psychodynamic treatment for severe personality disorders

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Abstract

The Borderline Psychotherapy Research Project at New York Presbyterian Hospital-Weill Cornell Medical Center, headed by Drs Otto Kernberg and John Clarkin has developed and tested a treatment for Borderline Personality Disorder called Transference Focused Psychotherapy. The theory, development and empirical research for the treatment are discussed. A pre-post study and a comparison to treatment as usual both showed promising results. The structure of the randomized controlled trial that is currently underway is also discussed.

Introduction

In the second half of the 20th century, psychoanalysis lagged behind other psychological orientations in generating empirical research [1]. The once-revolutionary methods of psychological investigation introduced by psychoanalysis, namely free association and interpretation, had not been supplemented with other experimental methods. At the same time, across the broader field of psychology, the emphasis on empirically validated psychotherapies increased ([2], see [3] for a critique of this approach), widening the research gap between psychodynamically oriented psychotherapies and other treatments. However, in recent years, psychodynamic psychotherapy has begun a culture change. A growing number of psychodynamic researchers are now applying methods that were once thought to be an awkward fit with psychodynamic therapy. Major efforts have been made in instrument development, the manualization of therapies, and process and outcome studies [4], [5], [6], [7], [8], [9]. There is also increasing dialogue with other fields, such as neurobiology, reflecting sophisticated attempts to link a psychodynamic understanding of pathology and treatment to physiological underpinnings. In this article, we discuss our own efforts in the study of psychodynamic psychotherapy, utilize our own research as an example of the strides being made in this area and as highlight important issues and developments in the field.

Since the early 1980's, the Borderline Psychotherapy Research Project at New York Presbyterian Hospital-Weill Cornell Medical Center, headed by Drs Otto Kernberg and John Clarkin, has been systematizing and investigating an object relations treatment of borderline patients. As part of this project, we have developed a manualized [10], [11], [12], modified psychodynamic treatment for patients with Borderline Personality Disorder called Transference Focused Psychotherapy (TFP).

TFP is a structured psychodynamic treatment based on Otto Kernberg's object relations model [13]. Kernberg's model focuses on the development of mental representations that are derived through the internalization of attachment relationships with caregivers. For Kernberg, the degree of differentiation and integration of these representations of self and others, along with their affective valence, constitutes personality organization. Borderline personality can be thought of as a severely disturbed level of personality organization, characterized by the use of primitive defenses (e.g. splitting, projective identification, dissociation), identity diffusion, and deficits in reality testing.

The major goals of TFP are better behavioral control, increased affect regulation, more intimate and gratifying relationships, and the ability to pursue life goals. This is hypothesized to be accomplished through the development of integrated self and object representations, the modification of primitive defensive operations and the resolution of identity diffusion that perpetuates the fragmentation of the patient's internal representational world. Thus, in contrast to therapies that focus on the short-term treatment of symptoms, the treatment we are developing has the ambitious goal of not just changing symptoms, but changing the personality organization which is the context of the symptoms.

We were committed to developing a new treatment—not just using existing psychodynamic treatments—that effectively targets borderline pathology. In that process, we have utilized the wisdom of the psychodynamic community; advances in object relations, attachment, and developmental theories; and data on the maturation of attention, effortful control and the sense of self and others. Our orientation combines theory, clinical experience, research findings, and the reformulation of the treatment in response to new data.

Section snippets

Matching the treatment to borderline pathology

It seems obvious that the treatment should be focused on the pathology in question. This presupposes detailed knowledge of the pathology, in terms of phenomenology, etiology, mechanisms of action, and course. If one is psychodynamically oriented, it includes hypotheses about the patient's inner life, including representations of self and others, and motivations for interpersonal behavior. We utilized the growing information on the borderline pathology, including cognition [18], temperament [19]

Development of a treatment manual

A critical component of psychotherapy research is a manual that describes in written form a psychotherapeutic approach in enough detail that clinicians at various sites can administer the same treatment (see [14] this issue, [15]). The standardization typically imposed by using psychotherapy manuals reduces outcome variation that is due to therapist differences, making it easier to draw valid inferences about treatment differences. Thus, a large number of psychotherapy treatment manuals have

Teaching the treatment

The written manual is only one of several training tools and procedures that we have developed in our efforts to teach TFP to mental health professionals. In the traditional method of teaching psychotherapy, therapists write process notes that are reviewed by supervisors. This method has certain pedagogical advantages, but we were interested in a more direct assessment of the psychotherapy process. Therefore, we utilized video-taped sessions, with review and discussion by our clinical research

Preliminary research on TFP

Once the treatment was manualized and taught to our therapists, we were prepared to begin the initial study of pre-post effects [5]. In 1994, we received a National Institute of Mental Health (NIMH) treatment development grant (Treatment Development for Borderline Personality Disorder Project, John F. Clarkin, PI) in order to continue the development of a treatment manual for TFP, a methodology for teaching and supervising TFP, and tools for assessing therapist adherence and competence in the

Pre-post psychotherapy changes

We analyzed outcomes in a set of parasuicidal variables that included the number of parasuicide attempts, the medical risk of all attempts, and the average resulting physical condition after the attempts. For this set of variables, the overall multivariate model was significant for the completer group and approached significance for the intent-to-treat group (P<0.06). In both the intent-to-treat and completer analyses, there was a significant decrease in the average medical risk of parasuicidal

Comparison study

We compared the results of patients diagnosed with BPD and treated with TFP to the results of a group of borderline patients who received one year of treatment as usual (TAU) in the same setting and system [26]. Significant differences between the TFP-treated group and the TAU group would greatly increase confidence in the benefits of TFP and support the undertaking of a randomized clinical trial of the treatment.

Participants continued to be recruited from all treatment settings within NYPH. In

Comparison study results

We examined the percent of patients with psychiatric ER visits and psychiatric hospitalizations within each group (TFP vs. TAU) as a function of time (baseline and end of treatment). For the TFP treated group, 20 (76.9%) of the 26 patients visited the ER in the year prior to treatment but only seven (26.9%) had ER visits during the treatment year. This difference was significant. For the comparison group, 13 (76.4%) of patients had ER visits in the year prior to evaluation and 14 (82.4%) had ER

Randomized clinical trial

Encouraged by the positive results obtained in the comparison study, we have embarked on a randomized clinical trial of TFP [7]. The primary purpose of the study is to compare the efficacy of TFP to an active treatment and a control. A cognitive–behavioral treatment called Dialectical Behavior Therapy (DBT) [29], which has received preliminary empirical support for its effectiveness, was selected as the active comparison treatment. The theoretical mechanisms of change in these two treatments

Domains of outcome

The domains of outcome in a psychotherapy study are determined by the goal of the treatment (what patient changes does the therapy intend), and the hypothesized mechanisms of change (predictors, mediators, and moderators). Thus, in this ongoing treatment study we assess the influence of treatment in reference to the central temperamental features of negative affect (i.e. lowered negative affect) and effortful control (i.e. increased effortful control/constraint), in addition to the changes in

Preliminary results

All psychotherapy sessions have been completed, and data are currently being analyzed. Some preliminary analysis has been completed on three assessment measures - Reflective Function (RF), coherence, and attachment [31]. Preliminary findings indicate that RF increased most dramatically for the TFP-treated group, but did not change significantly in either the DBT or supportive treatment groups. Coherence increased significantly for all three groups. Overall, there was a significant change among

Conclusion

Accumulating evidence indicates that Transference Focused Psychotherapy may be an effective treatment for Borderline Personality Disorder. As more data from the RCT is assessed, we will have a better understanding of how the treatment performs under more stringent experimental conditions. Because the RCT better controls for unmeasured variables through randomization, and offers controls for attention and support, and compares TFP to an already established, well-delivered, alterative treatment,

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