Original articlePancreas, biliary tract, and liverHealth-related Quality of Life in Nonalcoholic Fatty Liver Disease Associates With Hepatic Inflammation
Section snippets
Patient Characteristics
Patients with NAFLD were recruited at the University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany, at the Freeman Hospital Liver Unit, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, United Kingdom (UK), and at the University Hospital of the University of Seville, Spain, as part of the prospectively enrolling European NAFLD Registry, after written informed consent. Permission was obtained from the respective ethical commissions: Ethikkommission der
Patient Characteristics
A total of 304 patients were included in the study, 154 from the UK, 133 from Germany, and 17 from Spain. The mean age was 52.3 (±12.9) years, and 53.3% (n = 162) were male. The majority of patients (n = 228, 75.0%) were obese, with a median BMI of 33.3 kg/m2 (interquartile range, 30.0–37.5). Demographic data, characteristics of liver function, histopathological features, and differences between the countries are presented in Table 1. The majority of patients had moderate steatosis (grade 2,
Discussion
The current study explored HRQL in patients with biopsy proven NAFLD from 3 European centers. HRQL is an important facet when assessing the burden of a chronic disease. Despite the lack of specific symptoms in liver disease, patients can experience impairment in the quality of life at an individual level.27 In patients with NAFLD and other chronic liver disease, fatigue and impaired sleeping quality are the most frequently reported findings.12, 27, 28 Likewise, the number of comorbidities and
Acknowledgments
The authors thank the patients who were participating in the European NAFLD Registry.
References (38)
- et al.
Fibrosis stage but not NASH predicts mortality and time to development of severe liver disease in biopsy-proven NAFLD
J Hepatol
(2017) - et al.
Patient-reported outcomes and fatigue in patients with chronic hepatitis C infection
Clin Liver Dis
(2017) - et al.
Economic burden of hepatitis C infection
Clin Liver Dis
(2017) - et al.
Extrahepatic manifestations of hepatitis C: a meta-analysis of prevalence, quality of life, and economic burden
Gastroenterology
(2016) - et al.
Improvement of health-related quality of life and work productivity in chronic hepatitis C patients with early and advanced fibrosis treated with ledipasvir and sofosbuvir
J Hepatol
(2015) - et al.
Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030
J Hepatol
(2018) - et al.
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
Nat Rev Gastroenterol Hepatol
(2018) - et al.
Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease
Hepatology
(2018) - et al.
Nonalcoholic steatohepatitis: the therapeutic challenge of a global epidemic
Curr Opin Lipidol
(2011) - et al.
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
Hepatology
(2005)
Histopathological algorithm and scoring system for evaluation of liver lesions in morbidly obese patients
Hepatology
Liver transplantation for nonalcoholic steatohepatitis in the US: temporal trends and outcomes
Dig Dis Sci
Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
Nat Rev Gastroenterol Hepatol
Predictors of advanced fibrosis in non-cirrhotic non-alcoholic fatty liver disease in Germany
Aliment Pharmacol Ther
Fatigue in non-alcoholic fatty liver disease (NAFLD) is significant and associates with inactivity and excessive daytime sleepiness but not with liver disease severity or insulin resistance
Gut
Quality of life in adults with nonalcoholic fatty liver disease: baseline data from the nonalcoholic steatohepatitis clinical research network
Hepatology
Development of a disease specific questionnaire to measure health related quality of life in patients with chronic liver disease
Gut
The World Health Organization Quality of Life Assessment (WHOQOL): development and general psychometric properties
Soc Sci Med
The factorial structure of the Chronic Liver Disease Questionnaire (CLDQ)
Qual Life Res
Cited by (78)
Establishment of a machine learning predictive model for non-alcoholic fatty liver disease: A longitudinal cohort study
2024, Nutrition, Metabolism and Cardiovascular DiseasesHealth-related Quality of Life in Patients With Nonalcoholic Fatty Liver Disease: A Prospective Multi-center UK Study
2023, Clinical Gastroenterology and HepatologyThe Global Burden of Liver Disease
2023, Clinical Gastroenterology and HepatologyEconomic Burden and Patient-Reported Outcomes of Nonalcoholic Fatty Liver Disease
2023, Clinics in Liver DiseaseThe Potential Role of Fatigue in Identifying Patients With NASH and Advanced Fibrosis Who Experience Disease Progression
2023, Clinical Gastroenterology and HepatologyRisk factors for fibrosis progression in non-alcoholic steatohepatitis: Analysis of the European cohort in the real-world GAIN study
2023, Gastroenterologia y Hepatologia
Conflicts of interest The authors disclose no conflicts.
Funding This work was funded by H2020 under grant no. 634413 for the EPoS project and the Newcastle NIHR Biomedical Research Centre.
- b
Authors share co-senior authorship.