Clinical InvestigationDepression Predicts Repeated Heart Failure Hospitalizations
Section snippets
Description of HART
The Heart Failure and Retention Trial (HART) was a randomized controlled trial to evaluate the benefit of patient self-management skills training in combination with HF education over HF education alone. Powell et al13 provide a complete description of HART. The HART cohort included 902 participants who were randomized to a self-management intervention or education control and received 18 treatment contacts over 1 year, annual follow-ups, and 3-month phone calls to assess primary end points.
Results
Of the 902 subjects in HART, complete data were available for 784 subjects at baseline, with 14 subjects excluded because they died or were lost to follow-up within the first 60 days after randomization, 71 excluded because of missing 6-minute walk information, and 32 excluded because of missing data on age or income. Table 1 reports the characteristics of the 784 subjects at baseline. The sample was 53% male with an overall average age of 63.1 years (SD 13.2). The majority had an average
Discussion
Depression has been shown to increase the incidence of HF, decrease adherence to prescribed medical treatment, and increase the risk of mortality.4, 5, 6, 7 The present study provides further evidence that depression also increases the risk of costly repeated hospitalizations. Earlier studies on depression and hospitalizations for people with HF primarily examined whether subjects were hospitalized at least once or examined the time to hospitalization, rather than the number of times subjects
Disclosures
None.
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Depression Subtypes in Systolic Heart Failure: A Secondary Analysis From a Randomized Controlled Trial
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2022, JACC: Heart FailureCitation Excerpt :Whether treatment of depression improves HF outcomes may warrant further investigation. Among patients with prevalent HF, depression is associated with worse outcomes and increased mortality rate.8-10 To date, 2 trials have reported the effect of drug-based treatment of depression on cardiovascular outcomes among patients with prevalent HF.
The effect of persistent anxiety and depressive symptoms on quality of life among patients with heart failure
2021, Applied Nursing ResearchPrevalence of depressive symptoms in patients with Heart Failure in China: a meta-analysis of comparative studies and epidemiological surveys
2020, Journal of Affective DisordersCitation Excerpt :In addition, ethnic/race disparities in this study may also explain these above differences. Previous studies showed that HF patients with depressive symptoms were more likely at higher rehospitalization rates, higher risk of poorer quality of life, and increased mortality than non-depressed patients (Fang et al., 2008, Johnson et al., 2012). Mental disorders such as depression are among the leading causes of nonfatal burden of disease (Jakovljevic et al., 2019, Jakovljević et al., 2015, Jakovljevic et al., 2017, Jakovljevic et al., 2013, Mokdad et al., 2015, Jakovljevic, 2015).
Frequency of Utilization of Beta Blockers in Patients With Heart Failure and Depression and Their Effect on Mortality
2019, American Journal of Cardiology
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