Clinical InvestigationDifficulty Taking Medications, Depression, and Health Status in Heart Failure Patients
Section snippets
Study Population
Patients were recruited through the Cardiovascular Outcomes Research Consortium, a collaborative of investigators from 14 North American centers (Appendix). Outpatients with the diagnosis of heart failure in their medical record or a hospitalization for decompensated heart failure within 3 years were screened for participation. Patients with documented left ventricular ejection fraction <0.40 and who were older than 30 years of age were asked to participate and to provide informed consent.
Study Population
Of the 522 patients, 64 (12.2%) reported difficulty taking their medications. Patients with difficulty taking medications were less likely to be male, less likely to be white, and were younger than patients without difficulty taking their medications (Table 1). The 2 groups were similar with regard to left ventricular ejection fraction, etiology of heart failure, noncardiac factors, and medication regimens with the exception of digoxin use, which was more frequently prescribed among patients
Discussion
The objectives of this study were to evaluate the association between patient-reported difficulty taking medications as directed and health status among heart failure outpatients, and then to examine whether this association was explained by depression. We found that patients who reported difficulty taking their medications had significantly worse heart failure–related health status than patients without difficulty taking medications, independent of other demographic and clinical
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Depression Subtypes in Systolic Heart Failure: A Secondary Analysis From a Randomized Controlled Trial
2023, Journal of the Academy of Consultation-Liaison PsychiatryTrends in and predictors of multiple readmissions following heart failure hospitalization: A National wide analysis from the United States
2023, American Journal of the Medical SciencesCitation Excerpt :While some studies did not identify age as an independent predictor of readmissions, 31,32 others report higher rates of readmissions in younger patients.33 Potential reasons for this association could be more aggressive disease, increased prevalence of HF with reduced ejection fraction, non-compliance, lack of insurance and other comorbidities such as substance use and psychiatric illness among young patients.33–36 In agreement with these prior reports, patients with multiple readmissions had higher prevalence of substance use (5.5%, compared to 3% in single readmission) and depression (11.9% vs 11.1% in single readmission group) though the proportion of uninsured patients was similar in both groups (1.8% vs 1.9).
Psychological Disorders in Heart Failure
2022, Cardiology Clinics10-Year trend in the prevalence and predictors of depression among patients with heart failure in the USA from 2007–2016
2020, International Journal of CardiologyPsychological Disorders in Heart Failure
2020, Heart Failure ClinicsEditorial commentary: Re-inventing chronic disease management as a service – Medication adherence solutions are ground zero
2019, Trends in Cardiovascular Medicine
Funding for the KCCQ Study was provided by Pharmacia, Inc. Dr. Rumsfeld is supported by a VA Health Services Research Advanced Career Development Award (RCD 98341-2). Dr. Masoudi is supported by a NIA Career Development Award (KO8-AG01011).