Best Practice & Research Clinical Obstetrics & Gynaecology
1Perinatal mental illness: Definition, description and aetiology
Introduction
Perinatal mental illness is a significant complication of pregnancy and the postpartum period, and is frequently encountered by the obstetrician–gynaecologist. The chapters in this issue of Best Practice and Research Clinical Obstetrics and Gynaecology are principally concerned with the most prevalent disorders: major depression, bipolar disorder, and the anxiety disorders. In this chapter, we describe the various forms of perinatal mental illness and address issues relating to epidemiology and risk factors. Subsequent chapters will address detection of perinatal mental illness, effect of perinatal stress, anxiety, and psychotropic medications on the developing fetus and infant, the long-term prognosis of perinatal mental illness, the varieties of psychological and medical treatments, and psychiatric management of sleep disturbance and perinatal loss. The contributions come from colleagues in the USA, Canada, UK, Australia, France, India, and Pakistan, which gives this issue of Best Practice and Research Clinical Obstetrics and Gynaecology a diverse and international perspective on the problem and management of perinatal mental illness.
Perinatal mental illness has been recognised since the time of Hippocrates, and commented on through the centuries. In the 19th century, medical interest in perinatal mental illness accelerated, along with more general interest in severe mental illness. Marcé [1], the namesake of the major international society devoted to the study of perinatal mental illness (the Marcé Society for Perinatal Mental Health), published an important series of case studies of women suffering from various forms of perinatal mental illness over 150 years ago. Across the 20th century, clinical accounts and research on prevalence, risk factors, consequences to the mother, fetus, and infant expanded dramatically. Numerous government agencies and professional groups have issued guidelines for the detection and management of perinatal mental illness [2], [3], [4], *[5]. Increased clinical and professional attention, and financial resources directed towards perinatal mental illness are warranted given the significant effect of these psychiatric disorders on the lives of women, their children, and their families.
Studies on perinatal mental health also have been influenced by concepts emerging over the past 2 decades relating to the centrality of the fetal milieu in shaping health throughout the individual's life. The dynamic mix of biological, socio-environmental and psychological factors affect the expression of disease (and health) across the life span [6]. Fetal programming refers to the capacity of the in-utero environment to modify the expression of genes and interact with the genetic substrate to determine disease susceptibility in the short- and long-term. High levels of stress and associated mental illnesses affect maternal and fetal outcomes, and also long-term offspring health into adulthood. To the extent that negative biopsychosocial exposures can be diminished, eliminated, or replaced with positive factors, childbearing outcomes and the subsequent health of the mother of an offspring can be improved. Focusing intervention on the perinatal period builds upon women's interest in embracing positive health behaviours to invest in the welfare of their offspring, such as decreased smoking and alcohol use. This exciting area of investigation is reviewed in this issue by Vivette Glover.
Section snippets
Definition of perinatal mental illness
Perinatal mental illness refers to psychiatric disorders that are prevalent during pregnancy and as long as 1 year after delivery. The postpartum time-frame is debatable: most investigators use a period ranging from 4 weeks after delivery to 3 months after delivery. Perinatal disorders ranging from mild depression and anxiety, mania, to florid psychosis all fall under the rubric of perinatal mental illness. Additionally, disorders that were present before pregnancy, or recurring along with
Perinatal depression
Perinatal depression is defined in various ways. At one end of the spectrum, perinatal depression is defined symptomatically as exceeding a threshold on a screening measure, such as the Edinburgh Postnatal Depression Scale [7]. For example, pregnant and postpartum women are often asked to complete this 10-item questionnaire that asks about depression and anxiety-related symptoms over the past 7 days. Scores can range from 0 to 30, and women whose scores exceed a specified threshold (usually
Distinctiveness of perinatal mental illness
Perinatal psychiatric disorders might be distinct from similar disorders occurring at other times in a number of ways. For example, is the prevalence of psychiatric disorders increased in the perinatal period? Is the presentation of these disorders distinct? Do they respond to treatment in the same ways as similar disorders outside of the perinatal period? Are the risk or causal factors and pathophysiology distinct? What about courses of these disorders?
Is depression more common in the
Psychological and environmental underpinnings
Over the past 30 years, a great deal of research has addressed risk and causal factors for postpartum depression and, to a much less extent, depression during pregnancy. Several meta-analyses and systematic reviews have been completed and have arrived at similar conclusions [10], *[58], [59], [60]. On the basis of these reviews, risk factors with moderate to strong associations with postpartum depression include history of depression, depression and anxiety during pregnancy, neuroticism, low
Conclusion
Perinatal depression, anxiety, bipolar disorder, and postpartum psychosis represent mental health problems that, in the case of depression and anxiety, are relatively common and serious, and in the case of bipolar disorder and psychosis, while relatively less common, can have devastating consequences for the mother and her family. Postpartum blues are a common and less serious manifestation of affective disturbance, which emerge early in the postpartum period but have few negative sequelae.
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