Archival ReportAuditory Magnetic Mismatch Field Latency: A Biomarker for Language Impairment in Autism
Section snippets
Participants
Subjects with ASD were recruited from the Regional Autism Center of the Children's Hospital of Philadelphia, the Neuropsychiatry program of the Department of Psychiatry of the University of Pennsylvania School of Medicine, and from local and regional parent support groups, such as the Asperger Syndrome Information Alliance for Greater Philadelphia, Autism Society of America, and Autism Speaks. All children screened for inclusion in the ASD sample had a prior ASD diagnosis made by an expert
Results
Table 2 shows the mean and range of accepted deviant and standard trials for each group. In general, ASD subjects had slightly noisier data, resulting in fewer accepted epochs in the ASD than TD group for both standard and deviant stimuli. Although the TD group had more accepted trials than the ASD group, examination of Table 2 shows that the difference between groups was small and, as such, it is unlikely that the MMF findings are due to group differences in trial numbers (i.e., the number of
Discussion
As hypothesized, the main finding was a delayed MMF latency in children with autism, particularly pronounced in the ASD/+LI group. In light of the group MMF latency effect and absence of group by hemisphere, frequency, or stimulus interactions, the findings demonstrate that a delayed MMF latency in ASD is robust. Thus, it appears that the time course of the auditory mismatch response is a neural index of language impairment in ASD, a finding confirmed by receiver operator characteristic
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