Archival ReportMismatch Negativity, Social Cognition, and Functioning in Schizophrenia Patients
Section snippets
Participants
Thirty-three patients with schizophrenia (29 men, 4 women) and 42 normal control subjects (35 men, 7 women) participated in the study. All subjects were part of a larger study of early visual processing (Early Visual Processing in Schizophrenia; Principal Investigator: Michael Green). Schizophrenia patients were recruited from outpatient treatment clinics at the Veterans Affairs (VA) Greater Los Angeles Healthcare System and through presentations in the community. Twenty-seven patients were
Mismatch Negativity
Grand average MMN waveforms for each group are shown in Figure 1 and topographical maps are shown in Figure 2. As can be seen, both groups exhibited MMN activity in the expected frontocentral regions, though the patients exhibited clearly reduced MMN amplitudes. A 2 (group) × 34 (electrode) repeated measures ANOVA was performed to determine if there was differential responding across electrodes between groups. This initial analysis step, while not completely protecting analysis from type I
Discussion
This study is the first, to our knowledge, to examine correlations among MMN activity, daily functioning, and social cognition in schizophrenia patients. First, we replicated the finding of poorer MMN activity in schizophrenia patients compared with healthy control subjects. Second, the results of the study are consistent with prior reports showing significant correlations between MMN activity and daily functioning, using an expanded scale of daily functioning. Third, MMN was significantly
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