Original articleLongitudinal Stability of the CBCL-Juvenile Bipolar Disorder Phenotype: A Study in Dutch Twins
Section snippets
Subjects and Procedure
Data for this study come from an ongoing longitudinal study that examines environmental and genetic influences on the development of problem behavior in 3- to 12-year-old twins. The families are volunteer members of the Netherlands Twin Register (NTR), kept by the Department of Biological Psychology at the Free University, Amsterdam (Boomsma et al 2002b). Starting in 1987, families with newborn twins were recruited. Currently, 40%–50% of all multiple births in The Netherlands are registered by
Sample Characteristics and Descriptive Statistics
Table 1 shows the means and variances estimated in the saturated model across zygosity and sex. Table 2 shows the results of the tests for the homogeneity of means and variances. For all tests, the SRMR and CFI indicate that only the mean and variance differences across sexes can be considered relevant (SRMR > .05, CFI < .97). There is a tendency for male twins to show larger means and variability in CBCL-JBD than female twins.
The summary of twin correlations at each age and of the
Discussion
This study examined the stability and genetic architecture across time of the CBCL-JBD phenotype, which has been shown to be consistent with DSM conceptualizations of JBD. CBCL-JBD, defined as the sum of the AP, AGG, and A/D subscales, has been demonstrated to be associated with the DSM JBD phenotype across studies. The use of CBCL-JBD as a measure of DSM JBD has been recommended as one possible method to circumvent the diagnostic confounds that continue to be debated (National Institute of
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