Original articleChildhood Maltreatment, Subsequent Antisocial Behavior, and the Role of Monoamine Oxidase A Genotype
Section snippets
Participants
Participants were individuals in the National Youth Survey Family Study (Institute of Behavioral Science and Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado), a prospective longitudinal study of problem behavior from adolescence into adulthood. The National Youth Survey Family Study (NYSFS) is based on a national representative multi-stage probability sample of households in the continental United States (Elliott et al 1989). The original respondents include 1725
Results
Genotypic frequencies for those hemizygous 321 and 351 groups were 37% and 63%, respectively, within the entire NYSFS male sample. Within our study sample of Caucasian males, they were 35% and 65%, respectively. Genotypic distributions for both male samples were in Hardy-Weinberg equilibrium and not significantly different. These allelic and genotypic frequencies are similar to those reported elsewhere (Caspi et al 2002, Sabol et al 1998).
In the analysis sample of 277 youths, a total of 26 (9%)
Discussion
We examined the hypothesis that specific variation in MAOA genotype moderates the relationship between exposure to adolescent maltreatment and later antisocial behavior. We also extended the analyses of Caspi et al (2002) by examining the broader behavioral construct of violent victimization during adolescence. Similar to Caspi et al (2002), the current study included Caucasian males from a general population sample that had been followed longitudinally. Many of the behaviors examined here had
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