Elsevier

Brain and Cognition

Volume 75, Issue 1, February 2011, Pages 1-9
Brain and Cognition

Mental time travel into the past and the future in healthy aged adults: An fMRI study

https://doi.org/10.1016/j.bandc.2010.10.009Get rights and content

Abstract

Remembering the past and envisioning the future rely on episodic memory which enables mental time travel. Studies in young adults indicate that past and future thinking share common cognitive and neural underpinnings. No imaging data is yet available in healthy aged subjects. Using fMRI, we scanned older subjects while they remembered personal events (PP: last 12 months) or envisioned future plans (FP: next 12 months). Behaviorally, both time-periods were comparable in terms of visual search strategy, emotion, frequency of rehearsal and recency of the last evocation. However, PP were more episodic, engaged a higher state of autonoetic consciousness and mental visual images were clearer and more numerous than FP. Neuroimaging results revealed a common network of activation (posterior cingulate cortex, precuneus, prefrontal cortex, hippocampus) reflecting the use of similar cognitive processes. Furthermore, the episodic nature of PP depended on hippocampal and visuo-spatial activations (occipital and angular gyri), while, for FP, it depended on the inferior frontal and lateral temporal gyri, involved in semantic memory retrieval. The common neural network and behavior suggests that healthy aged subjects thought about their future prospects in the past. The contribution of retrospective thinking into the future that engages the same network as the one recruited when remembering the past is discussed. Within this network, differential recruitment of specific areas highlights the episodic distinction between past and future mental time travel.

Introduction

Episodic memory is the only memory system that allows individuals to mentally travel in subjective time, into either the past or the future (Tulving, 2002, Tulving, 2005). This ability depends on autonoetic consciousness which mediates an individual’s awareness of his or her existence and identity in subjective time. Converging lines of evidence from different fields of research indicate that remembering the past or envisioning the future share common cognitive and neural underpinnings. First, developmental studies suggest that the level of awareness for episodic remembering and the ability to identify with future interests develops around ages three to four (Atance and O’Neill, 2001, Levine, 2004, Wheeler et al., 1997). Second, age-related changes seem to affect similarly the quality of past and future mental evocations, with older adults generating fewer details for past and future events compared to younger adults (Addis, Wong, & Schacter, 2008). Third, neuropsychological case studies have shown that patients with hippocampal lesions have difficulties in remembering their personal past, but also in foreseeing their personal future (patient KC, Tulving, 1985; patient DB, Hassabis et al., 2007, Klein et al., 2002), their productions lacking in episodic details compared to age-matched controls (Addis et al., 2009, Gamboz et al., 2010). Fourth, certain phenomenological characteristics similarly affect past and future mental thinking, such as positive emotional valence and temporally close events which are associated with a stronger feeling of re-experiencing or pre-experiencing (Addis et al., 2008, D’Argembeau and Van der Linden, 2004, D’Argembeau and Van der Linden, 2006, Gamboz et al., in press). Most recently, a growing number of neuroimaging studies detect a common neural network when thinking about the past or the future (Buckner and Carroll, 2007, Hassabis and Maguire, 2007, Hassabis and Maguire, 2009, Schacter and Addis, 2007).

Main results from the neuroimaging literature indicate a striking overlap between past and future thinking, especially during the elaboration phase, attributable to common cognitive processes (Addis et al., 2007, Botzung et al., 2008, D’Argembeau et al., 2008, Hassabis et al., 2007, Okuda et al., 2003, Spreng and Grady, 2010, Szpunar et al., 2007, Weiler et al., 2010). Indeed, past and future representations are intimately linked to the self, mediated, in particular, by the medial prefrontal cortex (Gusnard et al., 2001, Kelley et al., 2002, Northoff and Bermpohl, 2004). Both past and future event constructions are strongly dependent on visual mental imagery, which increases the number of details retrieved and the subjective sense of remembering (Greenberg & Rubin, 2003), attributable to activity in the precuneus (Cavanna and Trimble, 2006, Fletcher et al., 1995). The ability to visualize complex spatial scenes is also necessary to mentally construct past or future events, reliant on activity in the posterior cingulate cortex (Hassabis et al., 2007, Szpunar et al., 2009, Szpunar et al., 2007). Past and future representations require the binding of details into a coherent event mediated by the medial temporal lobe, including the hippocampus (Eichenbaum, 2001). Its role in recombining details of past events during episodic autobiographical recollection has been shown previously (Viard et al., 2007, Viard et al., 2010) and extended to novel integration of details into coherent future events (Addis et al., 2007, Andrews-Hanna et al., 2010, Hassabis et al., 2007).

Different hypotheses have been proposed to account for this common core network. On one hand, Buckner and Carroll (2007) speculate that self-projection (i.e., the ability to mentally project oneself from the immediate present into a simulation of another time, place or perspective) may underlie the common brain network shared by past and future thinking, and other cognitive domains (theory of mind and navigation). A complementary idea, the “constructive episodic simulation hypothesis” formulated by Schacter and Addis (2007), posits that past and future events build on similar information stored in episodic memory and rely on similar cognitive processes (i.e., self-referential processing, imagery and flexible recombination of stored details). Novel events could, hence, be generated by reassembling and flexibly recombining stored event details. On the other hand, Hassabis and Maguire (2007) show that imagination, which may not depend on self-related nor on time-related processes, relies on the same brain regions. They propose that scene construction (i.e., the process of mentally generating and maintaining a complex and coherent scene or event) may better explain the commonalities in the brain areas engaged.

Although sharing remarkable similarities, both at the cognitive and neural level, past and future events obviously differ in that past events represent real experiences, while future events are based on predictions and estimations, reflected by differences at the phenomenological level. Past events contain more visual and other sensory details than future events (Addis et al., 2008, Anderson and Dewhurst, 2009, D’Argembeau and Van der Linden, 2004, D’Argembeau and Van der Linden, 2006), in line with the “reality monitoring framework” which posits that memories of real events include more sensory and contextual details than memories for imagined events (Conway et al., 2002, Johnson, 1991, Johnson and Raye, 1981). Moreover, participants experience past events with a clearer representation of contextual (spatial and temporal) information, with a more coherent story, and perceive the event more from a field perspective compared to future events (D’Argembeau & Van der Linden, 2006). Conversely, future simulations are rated as being more positive and personally significant compared to past events, indicating the existence of an optimistic bias towards the future (Addis et al., 2008, D’Argembeau and Van der Linden, 2006, Sharot et al., 2007). Past and future evocations also change as people get older and, although all age groups produce intentions, those of older people take place closer to the present, become less frequent as time from present increases (Spreng & Levine, 2006) and tend to contain less episodic details than younger adults (Addis et al., 2008). Up to now, no study has yet compared brain activation during past and future thinking in older people.

In this study, we used functional imaging to examine brain activations while projecting into the past or the future, in an older population. In the scanner, upon presentation of a cue-phrase prompting a specific past or future event (obtained by questioning a close family member), participants were asked to mentally recall specific events from the past 12 months and specific plans they intended to pursue in the next 12 months. Our first aim was to assess whether past and future thinking shared common neural bases in healthy aged people. Our second aim was to determine, if a neural overlap was observed, how it could be explained by the phenomenological quality of the events produced. Debriefing was particularly thorough as past and future mental evocations were rated on a five-point episodic scale, as well as on the mental strategy used, the quality and number of mental images retrieved, perspective taken, emotional intensity and valence. To test the idea of mental time travel in subjective time and examine the influence of retrospective thinking, additional scales not previously used in neuroimaging studies examining the future evaluated the state of consciousness, frequency of rehearsal and recency of last evocation.

Section snippets

Participants

Twelve right-handed (as measured by the Edinburgh handedness inventory) healthy females (mean age ± SD = 67.2 ± 5.2 years; ranging from 60 to 75 years old) with no history of psychiatric or neurological disorder were recruited through a university, a retirement association or a newspaper advertisement. To obtain a homogeneous group, we recruited only females. Indeed, gender-related differences have been shown to affect both the behavioral (Goddard, Pring, & Felmingham, 2005) and neural levels (Piefke &

Behavioral results

Behavioral results indicate that events from both past and future periods were comparable in terms of the strategy used (massively visual) and viewpoint of mental images (principally field), emotional intensity and valence, frequency of rehearsal and recency of the last evocation. In contrast, past memories were rated as more episodic (based on the EM score), were recalled with a higher state of autonoetic consciousness and had a better image quality and a higher number of mental images

Discussion

We used fMRI to explore the cerebral structures recruited by healthy aged subjects when thinking about personal specific events from the past 12 months (past) and the next 12 months (future), in an attempt to answer two main questions. First, do past and future thinking share a common neural basis in healthy aged adults? Second, if a neural overlap is present, how can it be explained by the phenomenological quality of the events produced? Neuroimaging results revealed a bilateral

Conclusion

This study showed that thinking about the past and the future recruits the same set of brains regions in healthy aged subjects reflecting the use of similar cognitive processes (visual imagery, semantic retrieval, episodic binding). When planning a future event beforehand, thinking retrospectively about it engaged the same regions as those recruited when thinking about a past event. However, past and future events differed on certain phenomenological aspects: past events were more episodic

Acknowledgments

Thanks to Dr. Alan Young for his help scanning participants and to Franck Lamberton and Nicolas Delcroix for technical support.

References (90)

  • R. Cabeza et al.

    Functional neuroimaging of autobiographical memory

    Trends in Cognitive Science

    (2007)
  • R. Cabeza

    Role of parietal regions in episodic memory retrieval: The dual attentional processes hypothesis

    Neuropsychologia

    (2008)
  • E. Ciaramelli et al.

    Top-down and bottom-up attention to memory: A hypothesis (AtoM) on the role of the posterior parietal cortex in memory retrieval

    Neuropsychologia

    (2008)
  • M.A. Conway et al.

    Neurophysiological correlates of memory for experienced and imagined events

    Neuropsychologia

    (2003)
  • A. D’Argembeau et al.

    Phenomenal characteristics associated with projecting oneself back into the past and forward into the future: Influence of valence and temporal distance

    Consciousness and Cognition

    (2004)
  • A. D’Argembeau et al.

    Individual differences in the phenomenology of mental time travel: The effect of vivid visual imagery and emotion regulation strategies

    Consciousness and Cognition

    (2006)
  • A. D’Argembeau et al.

    Neural correlates of envisioning emotional events in the near and far future

    NeuroImage

    (2008)
  • R.J. Dolan et al.

    Dissociable temporal lobe activations during emotional episodic memory retrieval

    NeuroImage

    (2000)
  • H. Eichenbaum

    The hippocampus and declarative memory: Cognitive mechanisms and neural codes

    Behavioural Brain Research

    (2001)
  • P.C. Fletcher et al.

    The mind’s eye-precuneus activation in memory related imagery

    NeuroImage

    (1995)
  • N. Gamboz et al.

    Episodic future thinking in amnesic mild cognitive impairment

    Neuropsychologia

    (2010)
  • S. Gardini et al.

    Left mediotemporal structures mediate the retrieval of episodic autobiographical mental images

    NeuroImage

    (2006)
  • C.D. Good et al.

    A voxel-based morphometric study of ageing in 465 normal adult human brains

    NeuroImage

    (2001)
  • D.L. Greenberg et al.

    The neuropsychology of autobiographical memory

    Cortex

    (2003)
  • D. Hassabis et al.

    Deconstructing episodic memory with construction

    Trends in Cognitive Science

    (2007)
  • B. Levine

    Autobiographical memory and the self in time: Brain lesion effects, functional neuroanatomy, and lifespan development

    Brain and Cognition

    (2004)
  • T. Nichols et al.

    Valid conjunction inference with the minimum statistic

    NeuroImage

    (2005)
  • G. Nigro et al.

    Point of view in personal memories

    Cognitive Psychology

    (1983)
  • G. Northoff et al.

    Cortical midline structures and the self

    Trends in Cognitive Science

    (2004)
  • J. Okuda et al.

    Thinking of the future and past: The roles of the frontal pole and the medial temporal lobes

    NeuroImage

    (2003)
  • J. Peters et al.

    Episodic future thinking reduces reward delay discounting through an enhancement of prefrontal–mediotemporal interactions

    Neuron

    (2010)
  • M. Petrides

    The mid-ventrolateral prefrontal cortex and active mnemonic retrieval

    Neurobiology of Learning and Memory

    (2002)
  • P. Piolino et al.

    Episodic autobiographical memories over the course of time: Cognitive, neuropsychological and neuroimaging findings

    Neuropsychologia

    (2009)
  • P. Piolino et al.

    Re-experiencing old memories via hippocampus: A PET study of autobiographical memory

    NeuroImage

    (2004)
  • A. Raposo et al.

    Ventrolateral prefrontal cortex and self-initiated semantic elaboration during memory retrieval

    Neuropsychologia

    (2009)
  • S. Steinvorth et al.

    Ecphory of autobiographical memories: An fMRI study of recent and remote memory retrieval

    NeuroImage

    (2006)
  • E. Svoboda et al.

    The functional neuroanatomy of autobiographical memory: A meta-analysis

    Neuropsychologia

    (2006)
  • D.R. Addis et al.

    Age-related changes in the episodic simulation of future events

    Psychological Science

    (2008)
  • R.J. Anderson et al.

    Remembering the past and imagining the future: Differences in event specificity of spontaneously generated thought

    Memory

    (2009)
  • W. Brewer

    What is autobiographical memory?

  • W. Brewer

    Memory for randomly sampled autobiographical events

  • W. Brewer

    What is recollective memory?

  • R. Cabeza et al.

    The parietal cortex and episodic memory: An attentional account

    Nature Reviews Neuroscience

    (2008)
  • L.L. Carstensen et al.

    Socioemotional selectivity theory and the regulation of emotion in the second half of life

    Motivation and Emotion

    (2003)
  • A.E. Cavanna et al.

    The precuneus: A review of its functional anatomy and behavioural correlates

    Brain

    (2006)
  • Cited by (104)

    View all citing articles on Scopus
    View full text