Short communicationThe study of food addiction using animal models of binge eating☆
Section snippets
The concept of food addiction
As reported at the Columbia University Seminar on Appetitive Behavior, the obesity epidemic has various proposed causes, one of which is the concept of “food addiction.” This theory posits that people can become addicted to food, in ways similar to how some people are addicted to drugs. It is thought that food addiction can lead to overeating, which can result in increased body weight or obesity in select individuals. Stories of “food addiction,” particularly “sugar addiction,” abound in the
Modeling food addiction in laboratory animals: a focus on binge eating
Laboratory animal models have been used to study food addiction. Beginning in Bart Hoebel's laboratory, we adapted models that were developed with rats for studying drug dependence to test for signs of food dependence, with the eventual goal of identifying the neurochemistry associated with these behaviors. Addiction in humans is a complex disorder; for simplicity it is discussed in three stages (American Psychiatric Association, 2000, Koob and Le Moal, 1997). Bingeing is defined as a bout of
An animal model of sugar bingeing
Our most studied model is that of sucrose bingeing. In this model, rats are maintained on a diet of 12-h access to a 10% sucrose solution (or 25% glucose in earlier studies) and standard rodent chow, followed by 12-h of sucrose and chow deprivation, for about one month. We have published extensively using this model and relating it to a variety of factors associated with addictive behavior. What follows is a summary of those findings (also see Table 1); details can be found in our review papers
Bingeing on a fat-rich food
As noted above, rats bingeing on sucrose do not gain excess body weight, suggesting that sucrose bingeing might foster characteristics of addiction, but it alone is probably not responsible for obesity or weight gain. However, we have shown that when a highly palatable combination of sugar and fat is offered to rats, it instigates binge eating and also increases body weight (Berner, Avena, & Hoebel, 2008). We reduced the duration of palatable food access from 12 to 2 h in order to make the binge
Summary and conclusions
The models of binge eating in rats described herein provide tools with which to study the concept of food addiction and its resultant neurochemistry. The data suggest that binge intake of sugar can have dopaminergic, cholinergic and opioid effects that are similar to those seen in response to some drugs of abuse, albeit smaller in magnitude. Newer data generated from studies of bingeing on a sweet-fat chow show that it produces increased body weight, providing a potential link to obesity. These
References (62)
- et al.
After daily bingeing on a sucrose solution, food deprivation induces anxiety and accumbens dopamine/acetylcholine imbalance
Physiology & Behavior
(2008) - et al.
Sugar-dependent rats show enhanced intake of unsweetened ethanol
Alcohol
(2004) - et al.
A diet promoting sugar dependency causes behavioral cross-sensitization to a low dose of amphetamine
Neuroscience
(2003) - et al.
Sugar-dependent rats show enhanced responding for sugar after abstinence: evidence of a sugar deprivation effect
Physiology & Behavior
(2005) - et al.
Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake
Neuroscience and Biobehavioral Reviews
(2008) - et al.
Underweight rats have enhanced dopamine release and blunted acetylcholine response in the nucleus accumbens while bingeing on sucrose
Neuroscience
(2008) - et al.
Sugar and fat bingeing have notable differences in addictive-like behavior
Journal of Nutrition
(2009) - et al.
Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response
Neuroscience
(2006) Chronic food restriction: enhancing effect on drug reward and striatal cell signaling
Physiology & Behavior
(2007)- et al.
Is binge eating experienced as an addiction?
Appetite
(2007)
Limited access to a dietary fat option affects ingestive behavior but not body composition in male rats
Physiology & Behavior
Compulsive overeating as an addiction disorder. A review of theory and evidence
Appetite
Preliminary validation of the Yale Food Addiction Scale
Appetite
Sucrose intake enhances behavioral sensitization produced by cocaine
Brain Research
Incubation of sucrose craving: effects of reduced training and sucrose pre-loading
Physiology & Behavior
Accumbens dopamine-acetylcholine balance in approach and avoidance
Current Opinion in Pharmacology
Refined food addiction: a classic substance use disorder
Medical Hypotheses
Depiction of food as having drug-like properties in televised food advertisements directed at children: portrayals as pleasure enhancing and addictive
Journal of Pediatric Health Care
Images of desire: food-craving activation during fMRI
Neuroimage
Dopamine microdialysis in the nucleus accumbens during acute and chronic morphine, naloxone-precipitated withdrawal and clonidine treatment
Brain Research
Daily bingeing on sugar repeatedly releases dopamine in the accumbens shell
Neuroscience
Opiate-like effects of sugar on gene expression in reward areas of the rat brain
Brain Research Molecular Brain Research
Decreases in dietary preference produce increased emotionality and risk for dietary relapse
Biological Psychiatry
Delta FosB-mediated alterations in dopamine signaling are normalized by a palatable high-fat diet
Biological Psychiatry
Effects of single and repeated morphine administration on the prodynorphin, proenkephalin and dopamine D2 receptor gene expression in the mouse brain
Neuropeptides
Morphine alters preproenkephalin gene expression
Brain Research
Mu opioid receptor signaling in morphine sensitization
Neuroscience
Diagnostic and Statistical Manual of Mental Disorders Fourth Edition Text Revision (DSM-IV-TR)
Lick the sugar habit
Examining the addictive-like properties of binge eating using an animal model of sugar dependence
Experimental and Clinical Research
Persistent upregulation of mu-opioid, but not adenosine, receptors in brains of long-term withdrawn escalating dose “binge” cocaine-treated rats
Synapse
Cited by (116)
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2023, Trends in Cognitive SciencesIncrement in the consummatory response induced by reward delay: An animal model of binge-like eating episodes
2022, Learning and MotivationThe influence of high-fat and high-sucrose feeding regimes on organ weight, body weight, and serum concentration of bioelements in rats
2022, Journal of Trace Elements in Medicine and BiologyNeurobiological and neuropharmacological aspects of food addiction
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The study supports the that there could be an addiction to sucrose as a food ingredient. Additionally, obtained results showed that bingeing on other palatable foods, including a fat-rich food, causes increased body weight (Avena, 2010). The association between food addiction and substance abuse has been applied to the YFAS (Gearhardt et al., 2016) using the criteria in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-V) Vahia, 2013.
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Based on a presentation by Nicole Avena at the Columbia University Seminar on Appetitive Behavior. September 17, 2009, Harry R. Kissileff, Chairman, supported in part by GlaxoSmithKline and The New York Obesity Research Center, St. Luke's/Roosevelt Hospital. This research was supported by USPHS grants DK-079793 (NMA), MH-65024 (Bartley G. Hoebel), and AA-12882 (BGH). Appreciation is extended to Dr. Bart Hoebel and Miriam Bocarsly for their suggestions on the manuscript.