Original articleNonsteroidal Anti-Inflammatory Drug or Glucosamine Reduced Pain and Improved Muscle Strength With Resistance Training in a Randomized Controlled Trial of Knee Osteoarthritis Patients
Section snippets
Study Design
The study was designed as a double-blinded, placebo-controlled, randomized intervention study in which individuals with knee OA performed 12 weeks of strength training. The patients were randomly assigned to treatment with placebo, ibuprofen, or glucosamine in combination with training. Staff personnel not involved in the project randomly assigned patients to the 3 groups using a random number table and prepared the medication for each patient. Study personnel and participants were blinded to
Results
In total, 181 persons with clinical OA of the knee were prescreened during the recruitment period. Of these, 122 were disqualified and 23 were not interested in participation (fig 1). The reasons for disqualification were lack of knee OA on radiographs or unilateral OA (28%), severe health problems (22%), previous knee trauma or operation (19%), age less than 50 or over 70 years (10%), other rheumatologic diseases (5%), regular training (8%), previous gastric ulcer (4%), or intolerance/allergy
Discussion
Important observations in the present study were that the gains in muscle mass (CSA) after a 12-week strength-training program in patients with knee OA did not differ between the NSAID, glucosamine, and placebo allocation groups. Gains in muscle mass are of high importance for patients with knee OA because muscle atrophy is a typical observation in patients with OA.1 To our knowledge, the effect of longer-term consumption of NSAIDs combined with physical training has been very sparsely
Conclusions
Clinically, the important question that arises from our study's findings is whether the improvement in muscle strength and reduction of pain seen with glucosamine or ibuprofen administration during physical training justifies treatment of patients with knee OA with these medications during training. The additional gain with medication combined with training found in our study does not seem large enough for the patient, especially when seen in light of the additional cost of the medication and
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Cited by (0)
Supported by the Nordea Foundation (Centre for Healthy Aging Grant), MYOAGE (grant no. 223576) funded by the European Commission under the Seventh Framework Programme, Danish Rheumatism Association, Danish Ministry of Health (grant no. 2006-1022-61), IMK Almene Fond (grant no. 30206-158), and Lundbeck Foundation (grant no. A1385).
No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit on the authors or on any organization with which the authors are associated.
Clinical Trial Registration Number: NCT00833157.