MiscellaneousLeft Ventricular Function Assessed by Two-Dimensional Speckle Tracking Echocardiography in Long-Term Survivors of Hodgkin's Lymphoma Treated by Mediastinal Radiotherapy With or Without Anthracycline Therapy
Section snippets
Methods
A total of 47 long-term survivors of Hodgkin's lymphoma (51 ± 9 years old) were divided into 2 groups according to previous lymphoma treatment either with or without anthracyclines at the Oslo University Hospital (The Norwegian Radium Hospital, Oslo, Norway) between 1980 and 1988. All patients had also undergone mediastinal radiotherapy. Additional details regarding patient selection and treatment have been published in our previous study of valvular dysfunction in survivors of Hodgkin's
Results
Both Hodgkin's lymphoma survivor groups had received a similar radiation dosage (Table 1). No significant differences were found in the demographic characteristics between those who had or had not received anthracycline (Table 1). Both patient groups were comparable with the healthy subjects in terms of age, although the heart rate was greater in the patient groups.
The patients who had received anthracycline and mediastinal radiotherapy had a significantly reduced global longitudinal strain
Discussion
The results of the present study have demonstrated a persistent decrease in LV function among the survivors of Hodgkin's lymphoma who had undergone mediastinal radiotherapy with or without additional chemotherapy more than 2 decades earlier. Our quantitative results have confirmed that anthracycline treatment deteriorates radiation-associated myocardial dysfunction in the long term.
Anthracyclines are effective antineoplastic agents used for a wide spectrum of hematologic malignancies and solid
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This work was supported by Madou Sin-Lau Hospital, the Presbyterian Church in Taiwan, the Inger and John Fredriksen Foundation, the South-Eastern Norway Regional Health Authority, and the Norwegian Research Council.