Coronary artery diseaseEffect of Depression on Late (8 years) Mortality After Myocardial Infarction
Section snippets
Methods
Patients with acute MI admitted to the cardiology service at the Johns Hopkins Bayview Medical Center, Baltimore, Maryland, from July 1, 1995, to December 31, 1996, were eligible for inclusion in the study if they had no major problems with cognition, were clinically stable enough to complete the interview, and did not have co-morbid noncardiac illness likely to cause death within the next 6 months.2 Acute MI was defined as ≥2 of typical ischemic chest pain lasting ≥20 minutes, presence of new
Results
A total of 284 patients were enrolled in the study and assessed using structured interview (n = 280), the BDI (n = 280), or both (n = 276). Details of numbers of patients meeting enrollment criteria and excluded patients were previously reported.2 Of 280 patients, major depression was diagnosed in 29 (10%), 26 (9%) had dysthymia, and 56 of 280 (20%) had a BDI score ≥10. Patients with any depression (n = 76; 27%) were significantly more likely to be white, have had a previous MI, have renal
Discussion
The major finding of this study was that any depression (defined as major depression, dysthymia, and/or BDI score ≥10) at the time of MI was not associated with long-term mortality, although it predicted 4-month mortality in a previous study in this cohort.2
To the best of our knowledge, 3 previous studies examined the relation of depression at the time of MI and mortality ≥5 years later,22, 23, 24 and each found an association between depression and long-term mortality. The discrepancy between
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Cited by (37)
Association of anxiety or depression with risk of recurrent cardiovascular events and death after myocardial infarction: A nationwide registry study
2023, International Journal of CardiologyPredictive value of depression and anxiety for long-term mortality: differences in outcome between acute coronary syndrome and stable angina pectoris
2018, International Journal of CardiologyCitation Excerpt :However, since the early 2000s treatment for ACS has moved from thrombolytic therapy to primary PCI (pPCI) and the association between depression or anxiety and long-term outcome has not been thoroughly investigated since then [1–3]. Prevalence rates of depression and anxiety in patients with coronary artery disease (CAD) in general vary from 10% to 50% [4–10]. Targeting psychological symptoms may provide improvements to the prognosis and quality of life in patients with CAD [11].
Relation of Anxiety and Depressive Symptoms to Coronary Artery Calcium (from the ELSA-Brasil Baseline Data)
2016, American Journal of CardiologyDepression is independently associated with 7-year mortality in patients treated with percutaneous coronary intervention: Results from the RESEARCH registry
2013, International Journal of CardiologyCitation Excerpt :The results of the current study corroborate those of previous studies in cardiac patients, demonstrating that depression is independently associated with an increased risk for short-term mortality [1,2,6–9,12,13]. The impact of depression on long-term mortality (> 5 years) has been studied previously, with these studies mainly focusing on post-MI patients [4,21], CABG patients [5,14], and patients referred for exercise testing [22], rather than PCI patients. The results of three of these previous studies were in line with the current study, showing a significant association between depression and long-term mortality [5,14,21], whereas other studies demonstrated that depression was significantly associated with short-term prognosis, but not with long-term prognosis [4,22].
Depression screening in patients with coronary heart disease: A critical evaluation of the AHA guidelines
2011, Journal of Psychosomatic ResearchCitation Excerpt :However, Carney et al. [26] suggest that the first episode of depression after the coronary event may have a stronger cardiac prognostic impact than recurring depression with previous onset. Also, it is not clear if depression arising within a few months of an ACS has the same cardiac prognostic implications as depression arising several months or a year later [27,28]. Both the period of onset of depression relative to the onset of CHD and the trajectory of depressive symptoms impact prognosis.
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Dr. Ziegelstein was supported by grant R21 NS048593 from the National Institutes of Health/National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, and the Miller Family Scholar Program.