MiscellaneousUsefulness of Uric Acid to Predict Changes in C-Reactive Protein and Interleukin-6 in 3-Year Period in Italians Aged 21 to 98 Years
Section snippets
Methods
The Invecchiare in Chianti; aging in the Chianti area (InCHIANTI) Study was an epidemiological study conducted on a representative sample of the population living in 2 Italian towns located in the Tuscany region of Italy. The study was developed to investigate factors affecting mobility in late life. The rationale, design, and data collection are described elsewhere.15 The study protocol complied with the Declaration of Helsinki and was approved by the Ethical Committee of the Italian National
Results
Baseline characteristics of study subjects for the entire sample and stratified by category of change in IL-6 and CRP between baseline and follow-up are listed in Table 1. Most associations were similar regardless of whether categories were defined based on IL-6 or CRP. Compared with subjects with persistently low or remitted inflammation (follow-up IL-6 ≤2.5 pg/ml or CRP ≤3 mg/L regardless of baseline values), those with increased inflammation (IL-6 baseline ≤2.5 pg/ml and follow-up >2.5; CRP
Discussion
Using data collected in the context of an epidemiological study performed in a population-based sample, we evaluated whether UA circulating levels predict IL-6 and CRP circulating levels during 3 years of follow-up. Independent of baseline inflammatory markers and relevant confounders, baseline UA and changes in UA from baseline to follow-up were significant predictors of CRP changes during a 3-year follow-up. Baseline UA and changes in UA from baseline to follow-up were also independent
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Anthocyanins in berries exhibited anti-atherogenicity and antiplatelet activities in a metabolic syndrome population
2020, Nutrition ResearchCitation Excerpt :A correlation that has been described here between CRP and serum uric acid levels, agrees with other studies [46,47]. A significant relationship was found between uric acid and inflammatory marker, such as CRP [47,48], suggesting that uric acid is not only a marker of the catabolic rate, but it may also be actively involved in the inflammatory process. The results of the current study presented that uric acid, similar to the CRP, had a downward trend from baseline, but not significantly, which was probably because of the short period of anthocyanin supplementation.
The link between insulin resistance parameters and serum uric acid is mediated by adiposity
2018, AtherosclerosisCitation Excerpt :A significant positive correlation between SUA and inflammation was also found in a small clinical series of heart failure patients [42,43]. Likewise, in prospective studies it has been reported that baseline SUA levels and changes in SUA predicted a 3-year change in CRP in a cohort of Italian men and women aged 21–98 years [44]. However, not all the information was in agreement since a study that included 333 elderly male Taiwanese individuals failed to find the association between SUA and inflammatory markers [45].
The InCHIANTI Study was supported as a “targeted project” (ICS 110.1/RS97.71) by the Italian Ministry of Health, Rome, Italy; Contracts No. N01-AG-916413 and N01-AG-821336 from the US National Institute on Aging, Bethesda, Maryland; and Contracts No. 263 MD 9164 13 and 263 MD 821336 from the Intramural Research Program of the US National Institute on Aging, Bethesda, Maryland. None of the sponsoring institutions interfered with the collection, analysis, presentation, or interpretation of the data reported here.