CardiomyopathyAcute Cardiac Functional and Morphological Changes After Anthracycline Infusions in Children
Section snippets
Methods
We prospectively enrolled children scheduled to receive treatment with anthracyclines (doxorubicin, daunorubicin, or idarubicin) for different malignancies. Echocardiographic studies were performed before the first dose and <2 hours after each of the first 3 doses of anthracyclines. Informed consent was obtained from parents and/or patients. The study was approved by the Medical Ethical Committee of University Hospitals Leuven.
A total of 13 patients (10 male) were enrolled. The mean age at
Results
Table 2 lists the standard echocardiographic measurements of systolic and diastolic function before and after anthracycline therapy. Heart rate, systolic and diastolic blood pressure, LV mass index, and LV end-systolic and end-diastolic dimensions did not significantly change immediately after each dose compared with baseline values. There was a significant increase in end-diastolic wall thickness after the first dose that persisted after subsequent doses. Compared with baseline, a significant
Discussion
Our study shows that subsequent low to moderate doses of anthracyclines induce acute deterioration in different parameters of systolic and diastolic cardiac function. Looking at geometric parameters, increased LV myocardial wall thickness with decreased wall thickening was noted after the first dose of anthracyclines. After subsequent doses, significant decreases in fractional shortening and the ejection fraction were also seen. LV diastolic function was affected after the first dose of
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This research was partly funded by the Fund for Scientific Research Flanders (FWO Vlaanderen), Flanders, Belgium.