Arrhythmias and conduction disturbanceEffects of Right Ventricular Pacing on Intra-Left Ventricular Electromechanical Activation in Patients With Native Narrow QRS
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Acknowledgments
We are indebted to Barbara Vidal, MD, Department of Cardiology, Hospital Clinic, Barcelona, Spain and Paola Di Stefano, BSc, and Tiziana De Santo, BSc, Medtronic Italy for their help in the preparation of the manuscript and the statistical analysis.
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Cited by (27)
Is there a right place to pace the right ventricle? Evaluation of apical and septal positions in a pacemaker population: Study protocol for a prospective intervention-control trial
2014, Contemporary Clinical TrialsCitation Excerpt :To ensure a constant capture of the right ventricle, the value of the AV delay is to be programmed at 40 ms shorter than the measured intrinsic PQ interval and in any case, no more than 120 ms. This value should be maintained for chronic pacing, unless otherwise prescribed. Assessment of the primary end-point will be based on the percentage of patients with an SLD > 41 ms [14] on pre-discharge echocardiogram performed during right ventricular pacing. The use of a baseline measurement will avoid the interference of the possible substrate modification that may occur in the period after implantation.
Early pacing-induced systolic dyssynchrony is a strong predictor of left ventricular adverse remodeling: Analysis from the Pacing to Avoid Cardiac Enlargement (PACE) trial
2013, International Journal of CardiologyCitation Excerpt :In a retrospective study, RVA pacing induced mechanical dyssynchrony was associated with deterioration of LV systolic function [17,21]. Although other small studies showed that systolic dyssynchrony is the major pathophysiologic mechanism of reduction in LV function over time, such link has not been established in prospective clinical trials [16–18,22]. Furthermore, a recent study demonstrated that the propensity for the occurrence of DYS might be different between heart failure patients with LBBB and RVA pacing-induced LBBB in those with preserved LV systolic function [23].
Worsening Left Ventricular Apical Peak Strain Early After Right Ventricular Pacing
2013, Ultrasound in Medicine and BiologyCitation Excerpt :There is an accumulating body of information suggesting that chronic RV (right ventricle) pacing leads to progressive LV (left ventricular) dysfunction and LV dilatation (Sweeney et al. 2003; Wilkoff et al. 2002; Vernooy et al. 2006; Tse et al. 2002). RV pacing alters the sequence of ventricular activation leading to interventricular dyssynchrony and a delay in LV activation (Tse et al. 2002; Lupi et al. 2006; Bordachar et al. 2003). Furthermore, it alters the sequence of activation of the left ventricle starting at the apex and ending at the base (Sade et al. 2009; Askenazi et al. 1984; Rosenqvist et al. 1991; Harper et al. 1991).
Ablate and pace: Is there still a role?
2012, Cardiac Electrophysiology ClinicsCitation Excerpt :Several studies have suggested that a high percentage of RV pacing may result in higher incidence of hospitalizations or death due to heart failure.36,37 Acute or chronic apical RV pacing causes ventricular dyssynchrony and may result in left ventricular dysfunction,38,39 which can be particularly detrimental in patients who have preexisting systolic dysfunction. Various studies showed inconsistent effects of the RV “ablate and pace” strategy on the LVEF, which can either decrease, increase, or stay unchanged.
Dilated Cardiomyopathy After Long-Term Right Ventricular Apical Pacing in Children With Complete Atrioventricular Block: Role of Setting of Ventricular Pacing
2009, Journal of Cardiac FailureCitation Excerpt :Nonetheless, because our study cohort was relatively small, the results were exploratory and need to be confirmed in further large-scale studies. Prior studies in adult patients have demonstrated that long-term asynchronous ventricular electromechanical activation caused by RV apical pacing worsen the ventricular function,7,20-23 leading to the development of heart failure in patients with and without preexisting LV dysfunction.10,24,25 In our study patients, we also found that RV apical pacing induced significant ventricular dyssynchrony, which was comparable to that in previous study.6