Coronary artery diseaseStatins and Postoperative Risk of Atrial Fibrillation Following Coronary Artery Bypass Grafting
Section snippets
Methods
We prospectively studied 234 consecutive patients (173 men; mean age 65 ± 9 years) who underwent coronary artery bypass grafting surgery between February 2002 and January 2003 at 2 university tertiary hospitals. Clinical features were noted, and a detailed transthoracic preoperative echocardiogram was obtained (to assess left atrial diameter, end-diastolic left ventricular diameter, and left ventricular ejection fraction). Patients who had previous permanent/persistent AF or atrial flutter,
Results
Clinical characteristics are listed in Table 1. Of 234 patients, 66 (28.2%) developed postoperative AF. In univariate analysis, only previous AF (p = 0.003) and the oldest quartile (p = 0.021) were associated with postoperative AF (Table 2). The use of statins was also associated with less AF (p = 0.024). There were no statistical differences between development of AF and type of statin used (p = 0.527). In multivariate analysis, previous AF (p = 0.026) and statin use (p = 0.038) were
Discussion
Among our consecutive patients who underwent coronary artery bypass grafting, those who used statins had a lower incidence of postoperative AF. In multivariate analysis, only nonuse of statin therapy and previous AF2 were statistically associated with development of AF after coronary artery bypass grafting. Of note, our findings are consistent with recent observations.3 Further, statins are protective against AF in patients who have stable chronic coronary artery disease4 and may prevent
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Mechanism and Prevention of Atrial Remodeling and Their Related Genes in Cardiovascular Disorders
2023, Current Problems in CardiologyCitation Excerpt :In 2006, Patti et al. used a randomized controlled study to confirm that statins can reduce the incidence of coronary artery bypass grafting complicated with AF and shorten the length of hospital stay.86 Marin et al. also reported that simvastatin can reduce the incidence of AF in patients after coronary artery bypass grafting.87 Ozaydin et al. reported that preoperative statin prophylaxis in patients with coronary artery bypass grafting can reduce the incidence of postoperative AF and shorten the duration of postoperative AF.88
Effects of Statins on First and Recurrent Supraventricular Arrhythmias in Patients with Mild Heart Failure (from the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)
2015, American Journal of CardiologyCitation Excerpt :It is well known that the incidence of SVA is increased after cardiac surgeries (mainly coronary artery bypass surgery)23,24 and in autoimmune inflammatory diseases,10,11 further supporting this theory. Statins were shown to reduce the occurrence of AF in numerous clinical trials.1–8 This property was related to some extent to their beneficial effect in stabilizing the atherosclerotic plaque, thus reducing ischemia.
The study was supported by Grant 2002 from the Fundación Juan Gil Albert, Diputación de Alicante, Alicante, Spain and Grant 2002, the Young Investigator’s Award, from Sociedad Valenciana Cardiología, Valencia, Spain.