Preventive cardiologyRelation of Coronary Atherosclerosis Determined by Electron Beam Computed Tomography and Plasma Levels of N-terminal Pro-Brain Natriuretic Peptide in a Multiethnic Population-Based Sample (The Dallas Heart Study)
Section snippets
Study population
The Dallas Heart Study is a population-based, multiethnic, probability sample of subjects in Dallas County. Details of the study design and the characteristics of the enrolled cohort have been previously described.13 All participants provided informed consent to participate in the study, and the Institutional Review Board of the University of Texas Southwestern Medical Center approved the study protocol. The study involved 3 separate visits, with the first consisting of field interviews and
Results
Subjects with older age, female gender, non-black race, lower body mass index, history of hypertension, myocardial infarction, or angina, use of angiotensin-converting enzyme inhibitors or β blockers, reduced LV ejection fraction, and LV hypertrophy had significantly higher plasma levels of NT–pro-BNP than subjects not meeting these criteria (Table 1). In contrast, no association was observed between diabetes mellitus, tobacco use, and hypercholesterolemia and plasma NT–pro-BNP levels.
Discussion
In a large and carefully phenotyped population-based cohort, we have demonstrated for the first time an independent association between the burden of coronary atherosclerosis, as measured by EBCT, and circulating levels of NT–pro-BNP. This association persisted after adjusting for LV structural and functional parameters, a history of myocardial infarction, and symptoms of angina pectoris, suggesting that atherosclerosis itself may stimulate natriuretic peptide synthesis and release. In
Acknowledgment
We thank Ronald Peshock, MD, for his interpretation of the cardiac magnetic resonance imaging results and Teresa Eversole, BS, for her administrative aid and Jody Balko, MMSc, for running the NT–pro-BNP assays. Reagents for NT–pro-BNP were provided by Roche Diagnostics, Indianapolis, Indiana.
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2016, Journal of Cardiovascular Computed TomographyCitation Excerpt :A secondary finding of our study was that CAC is an independent predictor of HF. Although there is evidence suggesting that CAC is associated with prevalent HF16 and with NT-pro-BNP,17 no previous evidence that CAC can adequately predict incident HF was available. This finding is not unexpected, as about half of all incident cases of HF are caused by CHD.18
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2014, AtherosclerosisCitation Excerpt :Several biomarkers relating to these processes have been studied and implemented as non-invasive tools for the diagnosis of CAD and for the prediction of future cardiovascular events in primary prevention. Established biomarkers include: NT pro-BNP, which is associated with ventricular dilatation and pressure overload [3–5]; hsCRP [6,7], involved in the inflammatory process; CysC [8–11], a marker of renal dysfunction; MPO, linked to both inflammation and oxidative stress [12–14]; hsTnI [15–17], associated with myocardial ischemia and VWF [18], which is known to be involved in coagulation. Sex-specific analyses on biomarkers for CAD may provide more insight into the underlying mechanisms of sex differences in CAD.
This study was supported by the Donald W. Reynolds Foundation, Dallas, Texas, and Roche Diagnostics, Indianapolis, Indiana, and partially supported by USPHS GCRC grant M01-RR00633 from the National Institutes of Health/NCRR-CR, Bethesda, Maryland. Dr. de Lemos was supported by grants and received consulting fees from Roche Diagnostics, Indianapolis, Indiana.